Search results for "crib"

The telomeric Cdc13-Stn1-Ten1 complex regulates RNA polymerase II transcription

2019

Advance article.

Regulation of the hDlg/hScrib/Hugl-1 tumour suppressor complex.

2008

The proper function of the Scribble tumour suppressor complex is dependent upon the correct localisation of its components. Previously we observed dynamic relocalisation of the hDlg component under conditions of osmotic stress. We now show that the other two components of the complex, hScrib and Hugl-1 display similar patterns of expression. We demonstrate, by shRNA ablation of hScrib expression, that hDlg and Hugl-1 are in part dependent upon hScrib for their correct localization. However under conditions of osmotic stress this apparent dependency no longer exists: hDlg and Hugl-1 localise to cell membranes independently of hScrib. We also demonstrate an interaction between the three compo…

The human protein Hugl-1 substitutes for Drosophila lethal giant larvae tumour suppressor function in vivo

2004

Drosophila lethal giant larvae: (lgl), discs large (dlg) and scribble (scrib) are tumour suppressor genes acting in a common pathway, whose loss of function leads to disruption of cell polarity and tissue architecture, uncontrolled proliferation and growth of neoplastic lesions. Mammalian homologues of these genes are highly conserved and evidence is emerging concerning their role in cell proliferation control and tumorigenesis in humans. Here we investigate the functional conservation between Drosophila lethal giant larvae and its human homologue Hugl-1(Llgl1). We first show that Hugl-1 is lost in human solid malignancies, supporting its role as a tumour suppressor in humans. Hugl-1 expres…

Cribra orbitaria and enamel Hypoplasia of the Iron-Age (IX-VII centuries b.C.) human group of Polizzello (Sicily).

2008

Packing a multidisperse system of hard disks in a circular environment.

2008

We consider the problem of finding the densest closed packing of hard disks with proposed different radii in a circular environment, such that the radius of the circumcircle is minimal. With our approach, we are able to find denser packings for various problem instances than known from the literature. Both for the dynamics of the simulation and for the optimum values of the radii of the circumcircles, we find various scaling laws.

Lulwoana sp., a dark septate endophyte (DSE) in roots of Posidonia oceanica (L.) Delile seagrass

2014

Posidonia oceanica is the most common, widespread and important monocotyledon seagrass in the Mediterranean Basin, and hosts a large biodiversity of species, including microorganisms with key roles in the marine environment. In this study, we ascertain the presence of a fungal endophyte in the roots of P. oceanica growing on different substrata (rock, sand and matte) in two Sicilian marine meadows. Staining techniques on root fragments and sections, in combination with microscope observations, were used to visualise the fungal presence and determine the percentage of fungal colonisation (FC) in this tissue. In root fragments, statistical analysis of the FC showed a higher mean in roots anch…

Sequence analysis of the rDNA spacer of Paracentrotus lividus and observations about pre-rRNA processing. NTS sequence of Paracentrotus lividus rDNA.

1993

We have isolated and sequenced one intergenic region and a small part of the flanking regions (18S and 26S rRNA coding regions) of the rRNA-encoding genes (rDNA) from the sea urchin Paracentrotus lividus. This region is about 3.8 Kb long. Northern blot hybridizations and S1 mapping experiments demonstrated the presence of a partially processed 21S rRNA precursor while has the same 5' terminus as the 32S primary precursor, also in developmental stages characterized by a low rate of rRNA synthesis.

Pythium perplexum isolated from soil in France: morphology, molecular characterisation and biological control.

2001

Pythium perplexum (F-926) was isolated from a soil sample taken in the Burgundy region in France. In 1907, it was mistakenly described by Bulter as P. vexans. Despite morphological resemblance, the comparison between the internal transcribed spacer 1 regions of the ribosomal DNA of the two fungi leaves no doubt of their different identities. P. perplexum was found to be highly pathogenic to cucumber seedlings. Damping-off disease of cucumber caused by P. perplexum can effectively be controlled by using the soil bacterium Serratia plymuthica (B-781). The details of the morphology and the molecular characterisation of P. perplexum and its biological control with S. plymuthica are described he…

Towards Concrete Syntax Based Find for Graphical Domain Specific Languages

2019

One of the main reasons why Model-Driven Engineering (MDE) technologies including Domain-specific modelling languages (DSML) have not reached the expected acceptance in the industry is a poor tool support. One of the features with a limited support even in commercial modelling tools is search (find). Typically, MDE tools support only a simple keyword-based textual search functionality. The same is true for the tools built using Domain-specific language (DSL) tool definition frameworks. It is proposed to provide the concrete syntax-based find functionality as a service of a DSL tool definition framework. The find diagrams are defined in a concrete syntax of a DSL. A definition of a DSL is us…

Il controllo degli insetti fitofagi nell'olivicoltura biologica.

2016

Puntuali strategie di controllo, campionamenti personalizzati e maggiore consapevolezza entomologica, insita nell’approccio del coltivatore biologico, consentono ottimi risultati quali-quantitativi ed economici nella difesa fitosanitaria in olivicoltura “organica” e in qualsiasi area olivicola italiana. Le minori spese fitosanitarie rispetto all’olivicoltura convenzionale inducono un sempre maggior numero di produttori alla conversione verso il bio. Gli autori illustrano le metodologie ammesse e consigliabili in regime di agricoltura biologica, per il controllo dei principali insetti fitofagi del olivo nel Mediterraneo, con particolare riferimento alla mosca delle oilve, Bactrocera oleae, e…