Search results for "croci"
showing 10 items of 419 documents
Assessment of tumor microcirculation with dynamic contrast-enhanced MRI in patients with esophageal cancer: initial experience.
2008
PURPOSE: To investigate the feasibility and impact of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) on tumor characterization and response to radiochemotherapy (RCT) in patients with esophageal cancer. MATERIALS AND METHODS: A total of 48 patients underwent DCE-MRI to assess tumor microcirculation based on a two-compartment model function. Effects of RCT on kinetic parameters were studied in 12 patients with squamous cell carcinoma. RESULTS: Tumor microcirculation differs with respect to histological subtype: squamous cell carcinomas showed lower values of amplitude A (leakage space, P = 0.015) and higher contrast agent exchange rates (k(21), P = 0.225) compared with adenoc…
Dynamic contrast-enhanced myocardial perfusion imaging using saturation-prepared TrueFISP.
2002
Purpose To develop and test a saturation-recovery TrueFISP (SR-TrueFISP) pulse sequence for first-pass myocardial perfusion imaging. Materials and Methods First-pass magnetic resonance imaging (MRI) of Gd-DTPA (2 mL) kinetics in the heart was performed using an SR-TrueFISP pulse sequence (TR/TE/α = 2.6 msec/1.4 msec/55°) with saturation preparation TD = 30 msec before the TrueFISP readout. Measurements were also performed with a conventional saturation-recovery TurboFLASH (SRTF) pulse sequence for comparison. Results SR-TrueFISP images were of excellent quality and demonstrated contrast agent wash-in more clearly than SRTF images. The signal increase in myocardium was higher in SR-TrueFISP …
Correlation of " in vivo" microcirculation and degeneration of the basal cells of the epithelium in lingual lichen planus
2010
Background: Oral lichen planus is an inflammatory chronic disease with an autimmune pathogenesis and unknown etiology that affects oral mucosa, with or without the involvement of the skin and other mucous membranes. The principal histological characteristics are the degeneration of the basal cell layer and the abnormal infiltration of inflammatory cells into the subepithelial layer of connective tissue. Objectives: This study is aimed to appraise if lingual lichen planus (LLP) is sustained by alteration of the oral microcirculation and if this abnormal vascularisation increases the degeneration of basal keratinocytes and the disruption of the basement membrane. Materials and Methods: Fiftee…
Effect of acute systemic hypoxia on human cutaneous microcirculation and endothelial, sympathetic and myogenic activity
2015
The regulation of cutaneous vascular tone impacts vascular vasomotion and blood volume distribution as a challenge to hypoxia, but the regulatory mechanisms yet remain poorly understood. A skin has a very compliant circulation, an increase in skin blood flow results in large peripheral displacement of blood volume, which could be controlled by local and systemic regulatory factors. The aim of this study was to determine the acute systemic hypoxia influence on blood flow in skin, local regulatory mechanism fluctuations and changes of systemic hemodynamic parameters. Healthy subjects (n=11; 24.9±3.7years old) participated in this study and procedures were performed in siting position. After 2…
Retinal vessel analysis and heart rate variability
2014
Heart rate variability (HRV) is used to index the vegetative nervous system and is linked with cardiovascular and nervous diseases [1]. Funduscopic assessment of the retinal vasculature can be utilized to evaluate the health status of microcirculation and to assess the predisposition of major vascular diseases [2]. The purpose of this study was, for the first time, to examine the influence of HRV on microcirculation as an early marker of cardiovascular alteration. The study population was comprised of apparently healthy employees of a high-tech company in Germany. The participants spanned the entire age of the work force (18–65 years) and all levels of socioeconomic status. A total of 292 s…
Human cerebral microcirculation and oxygen saturation during propofol-induced reduction of bispectral index †
2011
† This study investigates the effects of propofol-induced changes in bispectral index (BIS) on cerebral microcirculation and oxygenation during craniotomies. † In 2 mm cerebral depth, an increase in propofol dosage resulted in increased oxygen saturation (srvO2 )w ithout reduction of capillary venous blood flow (rvCBF). † Difference in oxygen content (avDO2) and approximated cerebralmetabolicrateofoxygen (aCMRO2) decreased with an increase in propofol dosage in 2 mm cerebral depth. † Alterations in BIS showed no effect on rvCBF, srvO2 ,a nd haemoglobin amount (rvHb) or on avDO2 or aCMRO2 in 8 mm cerebral depth. † These findings suggest that the CBF/CMRO2 ratio is altered by propofol in a re…
Sulodexide and the microcirculatory component in microphlebopathies.
1992
A double-blind, placebo-controlled study was carried out in 36 patients, aged 30 to 50 years, to evaluate the effectiveness of oral sulodexide in the treatment of chronic venous insufficiency due to idiopathic varices. Patients were allocated at random to receive either oral sulodexide as 2 capsules (each containing 250 lipoproteinolipase releasing units) twice daily or 2 identical placebo capsules twice daily over a period of 45 days. Using strain gauge plethysmographic data, assessments were made of the microcirculatory effects of treatment by calculating the coefficient of capillary filtration from measurements made on both legs of each patient on entry and after 30 and 45 days of treatm…
In vivo evaluation of periodontal microcirculatory changes associated with endodontic treatment.
2014
The purpose of this study was to investigate in vivo the gingival microcirculatory changes associated with endodontic treatment using the continuous wave of condensation technique. MATERIALS AND METHODS: Twenty necrotic one canal roots of 20 cooperative patients of both sexes, aged between 20 and 43 years, were selected. All patients were examined by capillaroscopy before, immediately after endodontic treatment, and after 7 days. The last examination was carried out by the same operator, and repeated twice for each examined area: masticatory, buccal and labial mucosa corresponding to the endodontically treated root. All canals were prepared using a simultaneous technique with Ni-Ti files (M…
Anatomical evaluation of oral microcirculation: capillary characteristics associated with sex or age group.
2009
Abstract Background There are various types of oral mucosa specific to different parts of the mouth and each of these has a unique histological structure. The variations in the epithelial structure are consistently related to observable differences in the underlying microcirculation: i.e. differences in the course, conformation, and density of capillaries. The aim of this research has been to investigate oral microcirculatory differences between men and women as well as between various age groups, in order to map the oral mucosa, and to highlight changes occurring during aging. Methods A total of 45 healthy subjects were enrolled for this study (12 men and 33 women; mean age 60.37; range 30…
Study of microcirculation in oral lichen planus by video-capillaroscopy.
2007
Objective The aim of this study was to evaluate “in vivo” the oral microcirculatory characteristics in patients with oral lichen planus (OLP) and to discover any differences in microcirculation in comparison with healthy patients. Study design Twenty patients with established diagnosis of OLP and 20 healthy patients were examined in our laboratory by means of contact optical probe videocapillaroscopy. The examined areas for each patient were the right and the left buccal mucosae. Capillary density and total capillary diameter, as well as afferent and efferent loop diameter were studied; the discovery of characteristic (tortuous, branched) loops was also investigated. Results The results wer…