Search results for "crp"

Radium-223 in mCPRC patients: a large real-life Italian multicenter study

2020

Background Radium-223 is a targeted alpha-particles therapy approved for the treatment of mCRPC patients with symptomatic bone metastases. To our knowledge we account for the largest cohort of mCRPC patients subjected to Radium-223 treatment in our country. We aim to describe in a real-life setting the largest cohort of mCRPC patients treated with Radium-223 ever taken into consideration. Methods 430 consecutive mCRPC patients were enrolled. Clinical data have been collected at baseline and at the end of the Radium-223 treatment. Furthermore, the overall survival(OS) of our population has been provided. Results 157 patients (36.5%) were still alive at the time of data analysis. A mean numbe…

Validation of proposed diagnostic criteria (the "Budapest Criteria") for Complex Regional Pain Syndrome

2010

Current IASP diagnostic criteria for CRPS have low specificity, potentially leading to overdiagnosis. This validation study compared current IASP diagnostic criteria for CRPS to proposed new diagnostic criteria (the "Budapest Criteria") regarding diagnostic accuracy. Structured evaluations of CRPS-related signs and symptoms were conducted in 113 CRPS-I and 47 non-CRPS neuropathic pain patients. Discriminating between diagnostic groups based on presence of signs or symptoms meeting IASP criteria showed high diagnostic sensitivity (1.00), but poor specificity (0.41), replicating prior work. In comparison, the Budapest clinical criteria retained the exceptional sensitivity of the IASP criteria…

The effects of enzalutamide and abiraterone on skeletal related events and bone radiological progression free survival in castration resistant prosta…

2017

Two new drugs, the CYP17 inhibitor abiraterone acetate and the androgen receptor (AR) antagonist enzalutamide, have recently shown to prolong OS prior chemotherapy or in docetaxel treated mCRPC patients, using steroidal therapy or placebo as control group. Updated analyses underlined the role of these new agents on two prostate-specific endpoints as radiographic progression-free survival (rPFS) and time to first skeletal-related event (tSRE). On the basis of these reports, we made an indirect comparison between abiraterone and enzalutamide. We obtained a clinically but not significant difference favouring enzalutamide over abiraterone in terms of rPFS (HR 0.48, 95% CI 0.22–1.02). No signi…

The predictive role of C-reactive protein in patients with hypertension and subclinical atherosclerosis.

2009

Recent guidelines published by the joint European Society of Hypertension/European Society of Cardiology have suggested the inclusion of C-reactive protein (CRP) in the standard assessment of cardiovascular risk in hypertensive patients, but little data is available on the role of CRP in patients with carotid lesions. We studied in 472 subjects, 236 with and 236 without hypertension, gender- and age-matched, with and without early stages of atherosclerosis (e.g. those with asymptomatic intima-media thickness >0.9 mm), the influence of all the other traditional cardiovascular risk factors (e.g. older age, male gender, obesity, diabetes, smoking habit, family history of coronary artery diseas…

Primary Radical Prostatectomy or Ablative Radiotherapy as Protective Factors for Patients With mCRPC Treated With Radium-223 Dichloride: An Italian M…

2020

Abstract Background We investigated, in a real-life setting, the prognostic relevance of previous primary treatment (radical prostatectomy [RP] or external beam radiotherapy [EBRT]) on overall survival for patients with metastatic castration-resistant prostate cancer (mCRPC) treated with radium-223 (223Ra). Materials and Methods In the present multicenter retrospective study, we enrolled 275 consecutive patients. The demographic and clinical data and mCRPC characteristics were recorded and evaluated at baseline and at the end of treatment or progression. 223Ra was administered according to the current label authorization until disease progression or unacceptable toxicity. We divided the who…

Association between Inflammatory Markers and Clinical and Metabolic Risk Factors for Cardiovascular Diseases

2009

Association between Inflammatory Markers and Clinical and Metabolic Risk Factors for Cardiovascular Diseases The inflammatory reaction plays an important role in the development of atherosclerosis. The clinical significance of the main inflammatory markers — C-reactive protein (CRP), interleukin 6 (IL6), tumour necrosis factor alpha (TNF-α), plasminogen activator inhibitor 1 (PAI1), etc. — has not been fully established. CRP, IL6, TNF-α, and PAI1 were assessed in 100 patients in terms of certain clinical indicators (sex, obesity indicators, blood pressure, and heart rate), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), trig…

Meta-Analysis of Genome-Wide Association Studies in >80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels

2011

Background— C-reactive protein (CRP) is a heritable marker of chronic inflammation that is strongly associated with cardiovascular disease. We sought to identify genetic variants that are associated with CRP levels. Methods and Results— We performed a genome-wide association analysis of CRP in 66 185 participants from 15 population-based studies. We sought replication for the genome-wide significant and suggestive loci in a replication panel comprising 16 540 individuals from 10 independent studies. We found 18 genome-wide significant loci, and we provided evidence of replication for 8 of them. Our results confirm 7 previously known loci and introduce 11 novel loci that are implicated in p…

Circulating levels of Matrix Metalloproteinases (MMP-2 and MMP-9), CRP and IL-6 during therapeutic treatment of patients with breast cancer

2008

Real Bodies. Donne, disabilità e diritti tra rivendicazioni e riconoscimento

2013

Alla Convenzione Onu sui diritti delle persone con disabilità va il merito, tra gli altri, di avere contribuito in modo decisivo a portare sul piano del diritto internazionale la soggettività delle donne con disabilità, destinatarie di una specifica previsione normativa (art. 6), nonché di numerosi riferimenti che sono espressione di una sensibilità di genere. Questa attenzione ha, chiaramente, ripercussioni giuridiche, laddove vengono rese finalmente visibili le violazioni dei diritti umani sofferte dalle donne con disabilità (segregazione, sterilizzazione forzata, abusi in primis). Non vanno taciuti nemmeno i risvolti sociali, dato che pregiudizi ed invisibilità ancora oggi caratterizzano…

Ketamīna lietošana kompleksā reģionālā sāpju sindroma (CRPS) ārstēšanā

2022

Nosaukums: Ketamīna lietošana kompleksā reģionālā sāpju sindroma (CRPS) ārstēšanā Autors: Serge Alan Johansson Darba vadītāja: Iveta Golubovska, Dr. Med. Anesteziologs, reanimatologs un algologs Priekšvēsture: Kompleksais reģionālais sāpju sindroms (CRPS) ir slikti izprasts stāvoklis, kad cilvēkam ir ilgstošas smagas un neciešamas sāpes. Lai gan lielā daļa CRPS gadījumu ir ievainojumu izraisīti, no tā izrietošās sāpes ir ilgstošas un intensīvas. Mērķi: Šī darba mērķis ir izpētīt ketamīna ietekmi uz CRPS ārstēšanu, salīdzinot Numerisko sāpju skalu (NRS) un Analgēzijas nocicepcijas indeksu (ANI). Materiāli un metodes: Pētījums tika veikts, ievadot nelielu Ketamīna devu 25 mg i.v. un novērtējo…