Search results for "current"

Importance of spin current generation and detection by spin injection and the spin Hall effect for lateral spin valve performance.

2018

Lateral spin valves are attractive device geometries where functional spin currents can be generated and detected by various mechanisms, such as spin injection and the direct and the inverse spin Hall effect. To understand the mechanisms behind these effects better, as well as their potential for application in devices, we combine multiple mechanisms in multi-terminal Pt-Py-Cu lateral spin valves: we generate pure spin currents in the copper spin conduit both via the spin Hall effect in platinum and electric spin injection from permalloy and detect signals both via conventional non-local detection and via the inverse spin Hall effect in the same device at variable temperatures. Differences …

Brief report: Assessing dispositional optimism in adolescence – Factor structure and concurrent validity of the Life Orientation Test – Revised

2014

Dispositional optimism is an individual difference promoting psychosocial adjustment and well-being during adolescence. Dispositional optimism was originally defined as a one-dimensional construct; however, empirical evidence suggests two correlated factors in the Life Orientation Test - Revised (LOT-R).The main aim of the study was to evaluate the dimensionality of the LOT-R. This study is the first attempt to identify the best factor structure, comparing congeneric, two correlated-factor, and two orthogonal-factor models in a sample of adolescents. Concurrent validity was also assessed.The results demonstrated the superior fit of the two orthogonal-factor model thus reconciling the one-di…

Computational Fluid Dynamics Simulation of Hydrodynamics and Stresses in the PhEur/USP Disintegration Tester Under Fed and Fasted Fluid Characteristi…

2015

ABSTRACT: Disintegration of oral solid dosage forms is a prerequisite for drug dissolution and absorption and is to a large extent dependent on the pressures and hydrodynamic conditions in the solution that the dosage form is exposed to. In this work, the hydrodynamics in the PhEur/USP disintegration tester were investigated using computational fluid dynamics (CFD). Particle image velocimetry was used to validate the CFD predictions. The CFD simulations were performed with different Newtonian and non-Newtonian fluids, representing fasted and fed states. The results indicate that the current design and operating conditions of the disintegration test device, given by the pharmacopoeias, are n…

Editorial - Current advances in cancer research: Therapeutics, Targets, and Chemical Biology.

2017

Der Einfluss von Wechselströmen verschiedener Stärke auf die Antibiotikaproduktion durch Schimmelpilze in Oberflächenkulturen

1952

Low alternating currents between 8 and 50 mA have a stimulating effect on the production of antibiotics by moulds in surface cultures using the medium ofVincent. Small differences of current intensity at low ranges cause no principally different results. The production of all antibiotics formed by the same species of mould is increased under the influence of low alternating currents.

Action of tertiary phenylalkylamines on cardiac transient outward current from outside the cell membrane.

1996

The effects of the phenylalkylamines verapamil (V), gallopamil (G), and devapamil (D) and their corresponding quaternary derivatives on the transient outward current (Ito) were examined in rat ventricular cardiomyocytes using the whole-cell patch-clamp technique. The question was addressed, whether phenylalkylamines act on Ito from the inside or the outside or from both sides of the cell membrane. To this end, the myocytes were either superfused extracellularly or perfused intracellularly with drug-containing solutions. In addition, the effects of verapamil were investigated at different pH-values. V, G, and D (30 microM each), applied extracellularly, reduced the steady state current of It…

Determination of fluoxetine enantiomers in pharmaceutical formulations by electrokinetic chromatography-counter current technique

2012

In this work, an electrokinetic chromatography–counter current procedure for the separation of fluoxetine enantiomers using highly sulfated β-cyclodextrin was optimized and applied to the determination of the enantiomers in three pharmaceutical formulations according to the matrix features. Quality criteria were applied to facilitate its transferability to testing laboratories. Fluoxetine was used therapeutically as the racemate, although a stereospecificity associated with its interactions with the neuronal serotonin-uptake carrier was demonstrated. In this context, the development of enantioselective methods for the chiral analysis of pharmaceuticals allowing stereoisomer ratio estimation…

Der Wärmehaushalt der Atmosphäre

1950

The mean caloric balance of the atmosphere is represented by diagram No. 1, which shows the usual lay-out, but is filled in with new figures according to own calculations based uponS. Fritz's new value of the earth's albedo. Possibilities of exchange between the heat surplus of the earth's surface and the heat deficiency of the atmosphere and between differing spots of the same layer are discussed. Regarding the vertical pattern of heat sources and cold sources, it may be seen that in the humid climates (tropics and temperate zone) the lower troposphere receives considerable amounts of heat and the upper troposphere and lower stratosphere lose heat, while in arid regions (subtropics and the…

Über das Wesen der optomotorischen Reaktionen

1953

Flying and swimming animals need to be able to avoid passive displacement by air and water currents. Optomotor reactions essentially serve this purpose. The animals must be able to distinguish precisely between sensory stimulation caused by passive displacement and by active locomotion. Stimulation due to active movements does not release optomotor reactions. Apparent exceptions to this rule, occurring only under artificial circumstances, are caused by a derangement of either normal sensory stimulation or normal movement and, consequently, of their normal correlation. Examples of both cases are discussed.

Effects of Quinine and Quinidine on the Transient Outward and on the L-Type Ca<sup>2+</sup> Current in Rat Ventricular Cardiomyocytes

2002

The effects of the enantiomers quinine and quinidine on the transient outward current (I<sub>to</sub>) and on the L-type Ca<sup>2+</sup> current (I<sub>Ca</sub>) were investigated in rat ventricular cardiomyocytes using the patch-clamp technique. At a stimulation frequency of 2 Hz, both quinine and quinidine depressed the magnitude of I<sub>to</sub> and I<sub>Ca</sub>; the half-maximal effects on I<sub>to</sub> were achieved at 11 and 15 µmol/l, respectively, and those on I<sub>Ca</sub> at 14 and 10 µmol/l, respectively. At 0.2 Hz, both drugs depressed the magnitude of I<sub>to</sub>, but not tha…