Search results for "curs"
showing 10 items of 1595 documents
Aspectos pragmático-lingüísticos del discurso del turismo de aventura: estudio de un caso: estudio de un caso
2014
El objetivo de este trabajo es ofrecer una visión general del discurso turístico con respecto a sus principales características pragmático-lingüísticas y contrastarlo con un subsegmento turístico concreto. En este caso, nos aproximaremos al turismo de aventura, un tipo de turismo que está creciendo exponencialmente en los últimos años y que, por tanto, está ganando importancia en el sector turístico en España. Para ello, analizaremos un corpus de textos promocionales sobre este tipo de turismo a fin de ejemplificar dichas características e ilustrar a los traductores profesionales acerca de las posibles dificultades que puedan encontrar durante la traducción de este tipo de textos al español…
Gestión del léxico turístico en páginas webs hoteleras de promoción: un ejemplo en alojamientos de la comunidad balear
2014
En este trabajo se muestran las nuevas posibilidades de gestión del léxico turístico a partir del análisis de páginas webs de promoción de alojamientos turísticos con la que se ha nutrido una base de datos. Se ilustrará la influencia decisiva del canal Internet en la promoción turística y las características con sello propio del nuevo discurso turístico generado en la web 2.0. Expertos en marketing y lingüistas se adaptan al cambio radical de paradigma y de género (cibergénero, macrogénero) con productos competitivos basados en la atribución continua de nuevos significados al léxico. Finalmente se presenta un modelo de trabajo con el corpus resultante de un grupo representativo de alojamien…
Estudio del problema social en el Hospital La Fe de Valencia desde la Unidad de Trabajo Social Hospitalario: recursos
2014
Objetivos: La investigación recoge los recursos aplicados por la Unidad de Trabajo Social Hospitalario valorando si son adecuados para solucionar la problemática detectada, así como la demora y satisfacción en los pacientes del Hospital Universitario La Fe de Valencia. Los recursos más solicitados y gestionados desde la Unidad de Trabajo Social Hospitalaria son los sociales (discapacidad, dependencia, Servicio de Ayuda a Domicilio y Servicios Sociales) siguiéndoles los sanitarios (hospital y prestaciones sanitarias complementarias). El 87,6% de los recursos se consideran adecuados para resolver la problemática planteada. El 76,5% se muestra satisfecho o complacido. El 67,5% de los pacientes…
Bienes comunes y democracia : hermenéutica crítica de las instituciones del procomún
2014
Esta investigación doctoral se tituló «Bienes Comunes y democracia. Hermenéutica crítica de las instituciones del procomún». Su argumento se basó en el proceso de «re-descubrimiento» de los bienes comunes, que está dando pie a la consolidación de un nuevo «enfoque interdisciplinar». Se trata de una respuesta teórica y práctica ante la unilateralidad de la racionalidad económico-estratégica, que busca el cercamiento del procomún bajo un equívoco argumento trágico, lo que lleva a su inevitable localización en la lógica bipolar público-estatal o privado-mercantil. Cabe un lugar preponderante en este nuevo enfoque a la escuela de análisis institucional de Elinor Ostrom, que ha roto con el deter…
Statins and the squalene synthase inhibitor zaragozic acid stimulate the non-amyloidogenic pathway of amyloid-beta protein precursor processing by su…
2010
Cholesterol-lowering drugs such as statins influence the proteolytic processing of the amyloid-beta protein precursor (AbetaPP) and are reported to stimulate the activity of alpha-secretase, the major preventive secretase of Alzheimer's disease. Statins can increase the alpha-secretase activity by their cholesterol-lowering properties as well as by impairment of isoprenoids synthesis. In the present study, we elucidate the contribution of these pathways in alpha-secretase activation. We demonstrate that zaragozic acid, a potent inhibitor of squalene synthase which blocks cholesterol synthesis but allows synthesis of isoprenoids, also stimulates alpha-secretase activity. Treatment of human n…
Brothers in arms: proBDNF/BDNF and sAPPα/Aβ-signaling and their common interplay with ADAM10, TrkB, p75NTR, sortilin, and sorLA in the progression of…
2021
Abstract Brain-derived neurotrophic factor (BDNF) is an important modulator for a variety of functions in the central nervous system (CNS). A wealth of evidence, such as reduced mRNA and protein level in the brain, cerebrospinal fluid (CSF), and blood samples of Alzheimer’s disease (AD) patients implicates a crucial role of BDNF in the progression of this disease. Especially, processing and subcellular localization of BDNF and its receptors TrkB and p75 are critical determinants for survival and death in neuronal cells. Similarly, the amyloid precursor protein (APP), a key player in Alzheimer’s disease, and its cleavage fragments sAPPα and Aβ are known for their respective roles in neuropro…
Shedding of the amyloid precursor protein-like protein APLP2 by disintegrin-metalloproteinases
2005
Cleavage of the amyloid precursor protein (APP) within the amyloid-beta (Aβ) sequence by the α-secretase prevents the formation of toxic Aβ peptides. It has been shown that the disintegrin-metalloproteinases ADAM10 and TACE (ADAM17) act as α-secretases and stimulate the generation of a soluble neuroprotective fragment of APP, APPsα. Here we demonstrate that the related APP-like protein 2 (APLP2), which has been shown to be essential for development and survival of mice, is also a substrate for both proteinases. Overexpression of either ADAM10 or TACE in HEK293 cells increased the release of neurotrophic soluble APLP2 severalfold. The strongest inhibition of APLP2 shedding in neuroblastoma c…
Constitutive and regulated α-secretase cleavage of Alzheimer’s amyloid precursor protein by a disintegrin metalloprotease
1999
Amyloid β peptide (Aβ), the principal proteinaceous component of amyloid plaques in brains of Alzheimer’s disease patients, is derived by proteolytic cleavage of the amyloid precursor protein (APP). Proteolytic cleavage of APP by a putative α-secretase within the Aβ sequence precludes the formation of the amyloidogenic peptides and leads to the release of soluble APPsα into the medium. By overexpression ofa disintegrinandmetalloprotease (ADAM), classified as ADAM 10, in HEK 293 cells, basal and protein kinase C-stimulated α-secretase activity was increased severalfold. The proteolytically activated form of ADAM 10 was localized by cell surface biotinylation in the plasma membrane, but the m…
Effect of a dominant-negative form of ADAM10 in a mouse model of Alzheimer's disease.
2009
The alpha-secretase cleaves in the non-amyloidogenic pathway the amyloid-beta protein precursor (AbetaPP) within the region of the amyloid-beta peptides to prevent their formation and aggregation in the brain. Members of the ADAM family (a disintegrin and metalloprotease) are the main candidates for physiologically relevant alpha-secretases. We recently demonstrated that overexpression of ADAM10 in mice transgenic for human AbetaPP (ADAM10 x APP[V717I]) alleviated functional deficits related to Alzheimer's disease. To further demonstrate that this is due to the specific activity of alpha-secretase, we characterized mice overexpressing an inactive form of ADAM10 (ADAM10[E384A]; ADAM10-dn). T…
Down-regulation of Endogenous Amyloid Precursor Protein Processing due to Cellular Aging
2005
Processing of amyloid precursor protein (APP) is a well acknowledged central pathogenic mechanism in Alzheimer disease. However, influences of age-associated cellular alterations on the biochemistry of APP processing have not been studied in molecular detail so far. Here, we report that processing of endogenous APP is down-regulated during the aging of normal human fibroblasts (IMR-90). The generation of intracellular APP cleavage products C99, C83, and AICD gradually declines with increasing life span and is accompanied by a reduced secretion of soluble APP (sAPP) and sAPPalpha. Further, the maturation of APP was reduced in senescent cells, which has been shown to be directly mediated by a…