Search results for "cycle"
showing 10 items of 3119 documents
Chromatin modifiers and recombination factors promote a telomere fold-back structure, that is lost during replicative senescence.
2020
Telomeres have the ability to adopt a lariat conformation and hence, engage in long and short distance intra-chromosome interactions. Budding yeast telomeres were proposed to fold back into subtelomeric regions, but a robust assay to quantitatively characterize this structure has been lacking. Therefore, it is not well understood how the interactions between telomeres and non-telomeric regions are established and regulated. We employ a telomere chromosome conformation capture (Telo-3C) approach to directly analyze telomere folding and its maintenance in S. cerevisiae. We identify the histone modifiers Sir2, Sin3 and Set2 as critical regulators for telomere folding, which suggests that a dis…
Recent improvements in PbO2 nanowire electrodes for lead-acid battery
2015
Abstract Lead oxide nanowires are an attractive alternative to conventional pasted electrodes, owing to their high surface area leading to high specific energy batteries. Here, we report the performance of template electrodeposited PbO 2 nanowires used as positive electrodes. Nanostructured electrodes were tested at constant charge/discharge rate from 2 C to 10 C, with a cut-off potential of 1.2 V and discharge depth up to 90% of the gravimetric charge. These new type of electrodes are able to work at very high C-rate without fading, reaching an efficiency of about 90% with a very good cycling stability. In particular, after an initial stabilization, a specific capacity of about 200 mAh g −…
Territori Interni. La Pianificazione Integrata per lo sviluppo circolare: metodologie, approcci, applicazioni per nuovi cicli di vita
2015
Territori Interni è il sedicesimo volume della collana Re-cycle Italy. La collana restituisce intenzioni, risultati ed eventi italiani ed europei connessi all’omonimo programma triennale di ricerca – finanziato dal Ministero dell’Istruzione, dell’Università e della Ricerca – che vede coinvolti oltre un centinaio di studiosi dell’architettura, dell’urbanistica e del paesaggio, in undici università italiane e numerosi partner scientifici e istituzionali internazionali. Obiettivo del progetto Re-cycle Italy è l’esplorazione e la definizione di nuovi cicli di vita per quegli spazi, quegli elementi, quei brani della città e del territorio che hanno perso senso, uso o attenzione. Il libro contrib…
Multidrug resistance reverting activity and antitumor profile of new phenothiazine derivatives
2008
Abstract A series of easily affordable phenothiazine derivatives bearing a rigid but-2-ynyl amino side chain were synthesized and tested to evaluate the MDR reverting activity and full antitumor profile. Some compounds endowed with remarkable MDR reverting effect were identified, and the most active one ( 6c ) was shown to increase doxorubicin retention in multidrug resistant cells, suggesting a direct interaction with P-glycoprotein. Furthermore, a broad range of cellular activities were observed for different compounds. In particular, the ability of some derivatives to induce antiproliferative effects on resistant cell lines and to interfere with the G 1 phase of the cell cycle, a phase u…
Interior Permanent Magnet Synchronous Machine Drive Powered by Fuel Cell for Automotive Applications
2020
Electric vehicles represent an optimal solution for the reduction of pollution in urban areas. In particular, the Fuel Cell (FC) technology is a promising solution especially for its charging times and zero CO2 direct emissions. The paper addresses the design and performance study of an Interior Permanent Magnet Synchronous Machine (IPMSM) drive powered by fuel cell for automotive applications. The IPMSM drive is powered by the use of 5,5 kW FC unit and it is composed of two DC-DC power converters and one inverter. In detail, a test bench has been carried out for the evaluation of the performances of each IPMSM drive conversion stage. Moreover, in order to simulate automotive working condit…
Recyclable Heterogeneous and Low-Loading Homogeneous Chiral Imidazolidinone Catalysts for α-Alkylation of Aldehydes
2014
Two polystyrene-supported and six homogeneous MacMillan imidazolidinone catalysts were prepared and tested for the asymmetric α-alkylation of propanal with benzodithiolylium tetrafluoroborate. The chiral imidazolidinone was linked to polystyrene through the N-3 atom or through the phenyl ring and their catalytic activity was compared with that of their unsupported precursors. This comparison has allowed us to find an unsupported catalyst that displays high catalytic activity down to 5 or 2 mol % at room temperature with a high level of enantioselectivity also when used with hexanal and 3-phenylpropanal. In addition, one of the heterogeneous materials was revealed to be highly recyclable for…
Synaptic tetraspan vesicle membrane proteins are conserved but not needed for synaptogenesis and neuronal function in Caenorhabditis elegans
2006
Tetraspan vesicle membrane proteins (TVPs) comprise a major portion of synaptic vesicle proteins, yet their contribution to the synaptic vesicle cycle is poorly understood. TVPs are grouped in three mammalian gene families: physins, gyrins, and secretory carrier-associated membrane proteins (SCAMPs). In Caenorhabditis elegans , only a single member of each of these families exists. These three nematode TVPs colocalize to the same vesicular compartment when expressed in mammalian cells, suggesting that they could serve overlapping functions. To examine their function, C. elegans null mutants were isolated for each gene, and a triple mutant was generated. Surprisingly, these animals develop …
The catalytic reduction of nitrobenzene at the [MoVIO2(O2CC(S)(C6H5)2)2]2? complex intercalated in a Zn(II)-Al(III) layered double hydroxide host: A …
2001
The heterogeneous reduction of nitrobenzene by thiophenol catalyzed by the dianionic bis(2-sulfanyl-2,2-diphenylethanoxycarbonyl) dioxomolybdate(VI) complex, [MoVIO2(O2CC(S)(C6H5)2)2]2−, intercalated into a Zn(II)–Al(III) layered double hydroxide host [Zn3−xAlx(OH)6]x+, has been investigated under anaerobic conditions. Aniline was found to be the only product formed through a reaction consuming six moles of thiophenol for each mol of aniline produced. The kinetics of the system have been analyzed in detail. In excess of thiophenol, all reactions follow first-order kinetics (ln([PhNO2]/[PhNO2]0) = −kappt) with the apparent rate constant kapp being a complex function of both initial nitrobenz…
Une nouvelle approche de l'enseignement des sciences économiques à l'université de Bourgogne : un bilan après deux ans d'expérimentation
2007
07016; International audience; Confrontée à une baisse significative de ses effectifs en L1 depuis plusieurs années, l'équipe pédagogique de sciences économiques de l'université de Bourgogne s'est engagée dans une réforme originale de ses enseignements. Trois objectifs pédagogiques ont été retenus : Offrir un encadrement individualisé, Faire le lien théorie – faits réels dans le contenu de l'enseignement, développer des compétences professionnalisantes chez les étudiants. Cette réforme a pris effet à la rentrée universitaire 2004-05 et a été mise en œuvre dans le cadre d'un nouveau cours pour lequel une évaluation originale des apprentissages des étudiants a été introduite et un accompagnem…