Search results for "cycle"
showing 10 items of 3119 documents
Progression of colorectal cancers correlates with overexpression and loss of polarization of expression of the htid-1 tumor suppressor.
2007
Recently, we identified htid-1, the human counterpart of the Drosophila tumor suppressor gene lethal(2)tumorous imaginal discs [l(2)tid], as a direct molecular ligand of the adenomatous polyposis coli (APC) tumor suppressor. The gene encodes three cytosolic (Tid50, Tid48 and Tid46) and three mitochondrial (Tid43, Tid40 and Tid38) proteins. In the colorectal epithelium the cytosolic forms hTid50/hTid48 interact under physiological conditions with the N-terminal region of APC. This complex which associates with additional proteins such as Hsp70, Hsc70, Actin, Dvl and Axin defines a novel physiological state of APC unrelated to beta-catenin degradation. Here we show that the expression of the …
The balance sheet accounts on the stress tests
2017
Este artículo estudia la influencia de la estructura del balance en la PD (probabilidad de incumplimiento) y LGD (pérdida dada por defecto) utilizando modelos econométricos. El objetivo es estudiar cómo afectan los agregados en el balance general a la DP y la LGD, distinguiendo estos efectos según el ciclo económico, de modo que se puedan aplicar a la prueba de resistencia. Los resultados indican que la estructura del saldo es importante en PD y LGD, especialmente con respecto a los fondos de los accionistas, los recursos del BCE y la cuenta de activos no corrientes mantenidos para la venta. También destaca la influencia del ciclo económico y el diferente comportamiento de la DP y la LGD co…
On Holditch's theorem and related kinematics
2019
El teorema de Holditch es un resultado clásico sobre áreas de curvas planas generadas por el movimiento de segmentos. Esta construcción está estrechamente relacionada con otros tipos de curvas como, por ejemplo, curvas paralelas, curvas de anchura constante o curvas de bicicletas. Se compilan las propiedades básicas de este tipo de curvas y se da una revisión histórica sobre el teorema de Holditch y teoremas relacionados de cinemática. Primero, la situación plana de Holditch se define rigurosamente y se consideran ciertos problemas como la existencia de dicha construcción o el modo de evitar movimientos retrógrados en el segmento que se va moviendo. En el enunciado del teorema de Holditch a…
Re-think, Re-load, Re-cycle: Mediterranean Urban Metamorphosis
2013
Metamorphosis is the new and powerful keyword in time of crisis. We are not undergoing a mere -even though dramaticpassing situation, but we are living in a crisis which requires a metamorphosis of the ecological, cultural, economic, social and political systems to get out of it other than we were when entering it. The metamorphosis will have to be mainly urban, because we are now in the Urban Age in which more than half the population live and work in cities, at levels exceeding 80% in Europe. The city, as the predominant form of inhabiting, is invested with the “responsibility” of producing innovative, more sustainable, intelligent and creative life styles, able of generating the innovati…
Re-imagine, Re-load, Re-cycle: New Urbanism for the City of Future
2014
The failure of European development model based on financial protocols urges the need to "re-think capitalism" toward a greater spatial dimension and a different approach in the use/reuse/reduction of the capitals utilised in development processes. Especially in Mediterranean Europe we have to restart from urban capitals (space, identity, quality, service and production) using them as renewed engines of sustainable growth (RE-IMAGINE). In the global change scenario, the shrinking city produces several urban "fragments", functional "chips" and "scraps" of development that, through a recycling process/project, can be brought back into urban infrastructures for new cycles of life (RE-CYCLE). T…
Re-cycle: molecolare/sistemico
2014
Il modello di sviluppo dopato entro cui abbiamo vissuto consolati dalle sue aporie ha prodotto una costante erosione di risorse urbane, di cui quella del suolo è solo una sineddoche, sebbene la più evidente. Abbiamo consumato soprattutto le strutture identitarie dei palinsesti culturali e le trame vegetali delle città, abbiamo anestetizzato metabolismi vitali e interrotto i cicli delle acque, dei rifiuti e della mobilità rendendoli inefficaci. Abbiamo eroso la capacità dell'urbano di intrattenere una relazione osmotica con il rurale, abbiamo sedato la capacità produttiva e generativa delle manifatture, così come abbiamo dimenticato il valore rigenerativo della manutenzione edilizia. La cris…
Re-cyclical Urbanism. Visions, Paradigms and Projects for the Circular Metamorphosis
2017
The European Commission has clearly stated that more intelligent, sustainable and competitive development requires a paradigm shift in which the territory is construed as a primary resource, considered the holder of “development cells”, which are too often underused or mystified with regard to their real potential for use (EC, Directorate-General for Research and Innovation, 2012). Cities designed and built on land rent — on which Italy set a benchmark — need to be replaced with cities of social and cultural profitability, value creation and jobs production. Cities that recycle already-used land to avoid energy waste, smarter cities — not just technologically, but also wiser and more sentie…
Developing Self-Awareness in Robots via Inner Speech
2019
The experience of inner speech is a common one. Such a dialogue accompanies the introspection of mental life and fulfills essential roles in human behavior, such as self-restructuring, self-regulation, and re-focusing on attentional resources. Although the underpinning of inner speech is mostly investigated in psychological and philosophical fields, the research in robotics generally does not address such a form of self-aware behavior. Existing models of inner speech inspire computational tools to provide a robot with this form of self-awareness. Here, the widespread psychological models of inner speech are reviewed, and a cognitive architecture for a robot implementing such a capability is…
Les déterminants de la réussite à l’université. Quels apports de la recherche en Éducation ? Quelles perspectives de recherche ?
2016
In France, the university is experiencing the problem of failure, especially in the first cycle. This article aims to establish, in a chronological perspective, a literature review of the contributions of educational research in the French context, the various factors contributing to this failure. The aim is firstly to show how evolved the research on the determinants of academic success since the 1990s. It is, secondly, to examine what types of research can still be conducted on the subject. That will lead us in particular that, despite questioning from several decades of university teaching, few studies have so far been conducted in the French context regarding the impact of teaching prac…
A sequence element downstream of the yeast HTB1 gene contributes to mRNA 3' processing and cell cycle regulation.
2002
Histone mRNAs accumulate in the S phase and are rapidly degraded as cells progress into the G(2) phase of the cell cycle. In Saccharomyces cerevisiae, fusion of the 3' untranslated region and downstream sequences of the yeast histone gene HTB1 to a neomycin phosphotransferase open reading frame is sufficient to confer cell cycle regulation on the resulting chimera gene (neo-HTB1). We have identified a sequence element, designated the distal downstream element (DDE), that influences both the 3'-end cleavage site selection and the cell cycle regulation of the neo-HTB1 mRNA. Mutations in the DDE, which is located approximately 110 nucleotides downstream of the HTB1 gene, lead to a delay in the…