Search results for "cycle"
showing 10 items of 3119 documents
Towards Practical Cybersecurity Mapping of STRIDE and CWE — a Multi-perspective Approach
2021
Software vulnerabilities are identified during their whole life-cycle; some vulnerabilities may be caused by flaws on the design while other appear due to advances on the technologies around the systems. Frameworks such as OWASP are well- known and are used for testing a systems security before or after implementation, and such testing is carried out against the existing system. Threat modeling however focuses on the early stages of the system design when it is feasible and easy to fix security-related flaws and prevent possible damage caused by them. For example, STRIDE is one very popular threat modeling framework. A STRIDE threat modelling specialist deals with abstract categorizations o…
Geogenic carbon dioxide degassing from active tectonic areas of the Balkan Peninsula
2023
Sin dagli anni ’70, la ricerca scientifica ha evidenziato una forte relazione tra il degassamento di carbonio profondo e le aree tettonicamente attive, sottolineando l’elevata importanza del contributo di queste emissioni nella quantificazione del carbonio globale. La Penisola Balcanica presenta grandi aree caratterizzate da degassamento di carbonio di origine mantellica, da attività vulcaniche Quaternarie, da un’elevata sismicità e da strutture tettoniche a scala regionale. Purtroppo, la stima del degassamento di anidride carbonica profonda in quest’area è ancora poco studiata. La ricerca di questa tesi di dottorato si è focalizzata sulla (i) stima dell’output di carbonio profondo dalle gr…
Stereoselective Synthesis of Spiro-Decalin Oxindole Derivatives via Sequential Organocatalytic Michael-Domino Michael/Aldol Reaction.
2022
A highly stereoselective procedure for the synthesis of spiro-polycyclic oxindoles bearing five contiguous stereogenic centers including two tetrasubstituted carbons has been developed. Under sequential organocatalysis performed by a pyrrolidine-based organocatalyst and DBU, a highly atom-economical Michael–domino Michael/aldol reaction sequence was optimized, yielding variously functionalized spiro-decalin oxindoles with excellent stereoselectivity (>99:1 dr, up to 92% ee). peerReviewed
Synthesis of Polycyclic Indolines utilizing a reduction/cyclization cascade reaction
2021
Subsequent reduction and dearomatizing cyclization reactions open up an entry into the synthesis of novel N-fused polycyclic indolines. The dearomatizing cyclization as key step of the sequence proceeds well with Cu(OTf)2 or TfOH as catalyst. At elevated temperature reduction of nitro-substituted precursors with iron under acidic conditions affords a broad variety of polycyclic indolines directly in a two-step cascade reaction in good to excellent yields. Using the developed protocol, the alkaloids Tryptanthrin and Phaitanthrin C have been prepared. peerReviewed
Sustainable design: study of the life cycle assessment of the production and packaging of wine
2003
The object of the study is the identification of the factors that interact with the environment during the production and the packaging of wine. For this aim is use an Economic Input-Output Life -Cycle assessment (EIO-LCA) and I-LCA database to access both the direct and indirect effects of supply chain on the environment and economy. In this phase is examines the impact on the environment by different types of packaging, and transport, the comparisons are made analyses energy, materials consumption and emissions in the environment.
Tre Sicilie: nascita, distruzione e ri-ciclo dei paesaggi siciliani
2015
L’evoluzione delle politiche sul paesaggio in Sicilia vive una sorta di tripartizione sia storica che geografica: paesaggi tutelati e iper-protetti, paesaggi in trasformazione e paesaggi in recupero si susseguono evolutivamente nella storia dell’Isola, ma si giustappongono anche fisicamente nella contemporaneità. Questa realtà è oggetto di questo contributo che indaga evoluzione ed esiti di creazione, trasformazione e riciclo di paesaggi in alcuni territori esemplari della Sicilia, con l’obiettivo di analizzare, selezionare e proporre buone (o cattive) pratiche nell’ambito della ri-generazione dei paesaggi. Il contributo in forma di cronistoria fortemente selettiva di alcuni fenomeni che ha…
L'audience et l'influence d'une revue mesurée à travers Internet : une application à Finance Contrôle Stratégie
2009
This article aims to show the interest of statistics available on the Internet concerning consultations of abstracts, downloads and citations of articles to assess the attractiveness and influence of a scientific review. This interest is illustrated by the case of the review Finance Contrôle Stratégie on the basis of the statistics provided by Repec and Publish or Perish. Beyond the findings that confirm the good performance of FCS and the usefulness of these statistics for the management of a scientific review, the article also provides insights into the life cycle of an article and the choice of the language of publication.
Large Azobenzene Macrocycles : Formation and Detection by NMR and MS Methods
2023
Azobenzene macrocycles are widely investigated as potential drug delivery systems and as part of molecular machines due to their photo-responsive properties. Herein, we detect the formation of a series of new azobenzene macrocycles that feature up to eight switchable repeating units. High-resolution mass spectrometry and ion mobility (IM) mass spectrometry experiments and 1H and diffusion-ordered spectroscopy (DOSY) NMR are used to detect the presence of the macrocycles that contain 10 to 40 aromatic rings in the gas phase and solution, respectively. The responsiveness of the Z-to-E photo-switching of the smallest of the macrocycles, exhibiting two azobenzene units and in total 10 aromatic …
Hyaluronic Acid Present in the Tumor Microenvironment Can Negate the Pro-apototic Effect of a Recombinant Fragment of Human Surfactant Protein D on B…
2020
Copyright © 2020 Murugaiah, Agostinis, Varghese, Belmonte, Vieni, Alaql, Alrokayan, Khan, Kaur, Roberts, Madan, Bulla and Kishore. Human surfactant protein D (SP-D) belongs to the family of collectins that is composed of a characteristic amino-terminal collagenous region and a carboxy-terminal C-type lectin domain. Being present at the mucosal surfaces, SP-D acts as is a potent innate immune molecule and offers protection against non-self and altered self-such as pathogens, allergens, and tumour. Here, we examined the effect of a recombinant fragment of human SP-D (rfhSP-D) on a range of breast cancer lines. Breast cancer has four molecular subtypes characterised by varied expression of oes…
3 ′-5 ′ crosstalk contributes to transcriptional bursting
2019
Abstract Background Transcription in mammalian cells is a complex stochastic process involving shuttling of polymerase between genes and phase-separated liquid condensates. It occurs in bursts, which results in vastly different numbers of an mRNA species in isogenic cell populations. Several factors contributing to transcriptional bursting have been identified, usually classified as intrinsic, in other words local to single genes, or extrinsic, relating to the macroscopic state of the cell. However, some possible contributors have not been explored yet. Here, we focus on processes at the 3 ′ and 5 ′ ends of a gene that enable reinitiation of transcription upon termination. Results Using Bay…