Search results for "cycle"

Rho GTPases are over-expressed in human tumors.

1999

Small GTPases of the Rho family are involved in the regulation of a variety of cellular processes, such as the organization of the microfilamental network, cell-cell contact and malignant transformation. To address the question of whether Rho proteins are involved in carcinogenesis in man, we compared their expression in tumors from colon, breast and lung with that of the corresponding normal tissue originating from the same patient. As shown by Rho-specific 32P-ADP-ribosylation, as well as Western-blot analysis, the amount of RhoA protein was largely increased in all 3 types of tumors tested. The most dramatic differences in the expression of Rho GTPases were observed in breast tissue. All…

Late Activation of Stress-activated Protein Kinases/c-Jun N-terminal Kinases Triggered by Cisplatin-induced DNA Damage in Repair-defective Cells

2011

Although stress-activated protein kinases/c-Jun N-terminal kinases (SAPK/JNK) are rapidly activated by genotoxins, the role of DNA damage in this response is not well defined. Here we show that the SEK1/MKK4-mediated dual phosphorylation of SAPK/JNK (Thr-183/Tyr-185) correlates with the level of cisplatin-DNA adducts at late times (16–24 h) after drug treatment in both human and mouse cells. Transfection of platinated plasmid DNA also caused SAPK/JNK activation. A defect in transcription-coupled nucleotide excision repair resting on a mutation in Cockayne syndrome group B protein promoted the late SAPK/JNK activation following cisplatin exposure. Signaling to SAPK/JNK was accompanied by act…

Problema o risorsa? I rifiuti, una risorsa per un design tra locale e globale

2010

Open Source & Shared Urban Design Platform

2017

Il progetto “ROMA 20-25 Nuovi cicli di vita per la Metropoli”, promosso dall’Assessorato alla Trasformazione Urbana del Comune di Roma e dal MAXXI, Museo Nazionale delle Arti del XXI secolo, ha chiamato ventiquattro scuole di architettura, università italiane e internazionali, a interpretare il presente urbano di Roma e immaginarne il futuro attraverso un workshop internazionale di progettazione e una mostra, coinvolgendo le Unità di Ricerca del PRIN “RE-CYCLE Italy. Nuovi cicli di vita per architetture e infrastrutture della città e del paesaggio”. Il contributo dell'Unità di Ricerca dell’Università di Palermo "Re-forming verso la Agri/FabCity per Roma 20-25" è stata l'occasione per sperim…

Pavement Management System model using a LCCA- microsimulation integrated approach

2014

The maintenance and the rehabilitation of the urban road pavements are not often based on systematic program and scheduling but rather on emergency or on other not identified reasons. Moreover the Life Cycle Cost Analysis (LCCA), the only peculiar procedure for the management pavement, finds its own application for highway and motorway, even if it is possible to search the best investment for the urban interstate and arterials. By the light of the quantity of the involved resources, it seems necessary to define an operative methodology for programming the maintenance and rehabilitation activities for the urban pavement. The paper is oriented towards the development of a multidisciplinary ap…

A multidisciplinary approach using LCCA and micro-simulation 10 model for the management of the urban pavements

2013

The maintenance and the rehabilitation of the urban road pavements are not often based on systematic program and scheduling but rather on emergency or on other not identified reasons. Moreover the Life Cycle Cost Analysis (LCCA), the only peculiar procedure for the management pavement, finds its own application for highway and motorway, even if it is possible to search the best investment for the urban interstate and arterials. By the light of the quantity of the involved resources, it seems necessary to define an operative methodology for programming the maintenance and rehabilitation activities for the urban pavement. The paper is oriented towards the development of a multidisciplinary ap…

The impact of weather and the phase of the rodent cycle on breeding populations of waterbirds in Finnish Lapland

2016

Climate change may affect bird populations both directly by changing the weather conditions, and indirectly through changes in the food chain. While both theoretical and empirical studies have shown climate change having drastic impacts on polar areas, its consequences on Arctic bird species are still poorly known. Here we investigated how weather and changes in predator–prey interactions affected the annual growth rates of sub-Arctic birds by monitoring the breeding numbers of three duck and seven wader species in the alpine tundra of Finnish Lapland during 2005–2015 (except for 2006). We hypothesized that growth rates of waterbirds would be positively associated with warm and dry weather …

Abemaciclib: safety and effectiveness of a unique cyclin-dependent kinase inhibitor

2020

Introduction: The discovery and the clinical availability of novel cyclin-dependent kinases 4 and 6 inhibitors have profoundly changed the therapeutic scenario of metastatic hormone receptor-positive breast carcinoma. Among these inhibitors, abemaciclib can induce potent and sustained cell cycle arrest and immune system stimulation. Areas covered: This review summarizes the safety profile and clinical efficacy data on abemaciclib alone or in combination with aromatase inhibitors or fulvestrant in metastatic hormone receptor-positive breast carcinoma. The management of patients treated with abemaciclib is the object of this paper. Expert opinion: As shown in phase 2 and 3 clinical trials on …

School Staff-centered School Development by Communicative Action: Working Methods for Creating Collective Responsibility - From the Idea to Action

2020

School development is often seen as a concerted (re-)action to educational policies, curriculum development, and change in education laws or regulations, and sometimes, as stakeholders’ reactions to low school performance. Generally, school development incorporates organizational, managerial, and educational activities and measures. This is done to adapt to the new situation to achieve the desired changes and goals initiated by a given curriculum reform. In contrast, this paper focuses on school staff–driven development: It describes how teachers together with paraprofessionals contribute to school-development. Using collective responsibility creating working methods of communication, the e…

Infrastructural and Human Factors Affecting Safety Outcomes of Cyclists

2018

The increasing number of registered road crashes involving cyclists during the last decade, and the high proportion of road crashes resulting in severe injuries and fatalities among cyclists constitutes a global issue for community health, urban development, and sustainability. Nowadays, the incidence of many risk factors for road crashes of cyclists remains largely unexplained. Given the importance of this issue, the present study has been conducted with the aim of determining relationships between infrastructural, human factors and safety outcomes of cyclists. Objectives: This study aimed, first, to examine the relationship between key infrastructural and human factors present in cycling,…