Search results for "cyclic"

showing 10 items of 2439 documents

ChemInform Abstract: Palladium-Catalyzed Alkoxy- and Aminocarbonylation of α-Halomethyl Oxime Ethers: Synthesis of 1,3-Alkoxyimino Esters and 1,3-Alk…

2015

The three component reactions of α-bromomethyl oxime ethers, carbon monoxide, and alcohols or aromatic amines give imino esters and amides, respectively.

chemistry.chemical_compoundchemistryAlkoxy groupOrganic chemistrychemistry.chemical_elementheterocyclic compoundsGeneral MedicineOximeCarbonylationCatalysisCarbon monoxidePalladiumChemInform
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ChemInform Abstract: Rhodium(III)-Catalyzed Ring-Opening of Strained Olefins Through C-H Activation of O-Acetyl Ketoximes: An Efficient Synthesis of …

2014

An efficient strategy for the stereoselective synthesis of functionalized cyclopentenes and spiro[2.4]heptenes from strained olefins via C–H activation of aryl ketone O-acetyl ketoximes using [RhCl2Cp∗]2 catalyst is described. The results revealed that a wide range of readily accessible aryl and heteroaryl ketoximes are compatible in this method for the ring opening of bicyclic and spirotricyclic olefins.

chemistry.chemical_compoundchemistryBicyclic moleculeArylchemistry.chemical_elementOrganic chemistryStereoselectivityGeneral MedicineAryl ketoneRing (chemistry)Medicinal chemistryRhodiumCatalysisChemInform
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Multinuclear magnetic resonance study of 1,3,3-trimethylbicyclo [2.2.1]heptan-2-one (fenchone) oxime, its five monochloro derivatives and a dehydroch…

1991

Fenchone oxime, 5-exo-chlorofenchone oxime, 6-exo-chlorofenchone oxime, 7-anti-chlorofenchone oxime, 8-chlorofenchone oxime, 9-chlorofenchone oxime and a dehydrochlorination product of 10-chlorofenchone oxime were synthesized from fenchone and the corresponding chlorofenchones. The 1H, 13C and 17O NMR spectra of the oximes and the dehydrochlorination product were recorded. The NMR data were compared with the corresponding parameters obtained earlier for fenchone and monochlorofenchones in order to determine the differences between the carbonyl and oxime substituents from the NMR spectroscopic point of view, and to assign the stereochemistry of the oxime group. This stereochemistry could not…

chemistry.chemical_compoundchemistryBicyclic moleculeMagnetic resonance studyOrganic chemistryMoleculeGeneral Materials ScienceGeneral ChemistryNuclear magnetic resonance spectroscopyOximeNmr dataFenchoneMagnetic Resonance in Chemistry
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Why Do Five-Membered Heterocyclic Compounds Sometimes Not Participate in Polar Diels–Alder Reactions?

2013

The reactions of bicyclic enone (BCE, 1) with cyclopentadiene (Cp, 2) and the five-membered heterocyclic compounds (FHCs) furan 3 and N-methyl pyrrole 4 for the construction of polycyclic heterocyclic compounds have been studied at the B3LYP/6-31G* level. No reaction takes place in the absence of Lewis acid (LA) catalysts as a consequence of the high activation energy associated with these reactions. Electrophilic activation of BCE 1 by formation of a complex with the BF3 LA, 1-BF3, and solvent effects favor the reactions. However, a different reactivity is manifested by Cp 2 and FHCs 3 and 4. Thus, while the reaction of 1-BF3 with Cp 2 yields the expected exo [4 + 2] cycloadduct, the react…

chemistry.chemical_compoundchemistryBicyclic moleculeNucleophileStereochemistryFuranOrganic ChemistryElectrophileLewis acids and basesSolvent effectsEnonePyrroleThe Journal of Organic Chemistry
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Diels-Alder reactions of 1-phenylpyrano[3,4-b]indol-3-ones with alkynes: New functionalized carbazoles

1990

3-Indolylalkanoic acids 2 react with benzoic acid anhydride under catalysis of Et2O - ZnCl2 and mild conditions to furnish the 1-phenyl-substituted pyrano[3,4-b]indol-3-ones 1c, 1d, and 3a, 3b. Products 1c, 1d, and 3b may be converted into the novel functionalized carbazoles 4 and 5 by reaction with acceptor-substituted alkynes.

chemistry.chemical_compoundchemistryBicyclic moleculeOrganic ChemistryChemical conversionDiels alderOrganic chemistryPhysical and Theoretical ChemistryAliphatic compoundBenzoic acidCatalysisLiebigs Annalen der Chemie
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Polycondensed nitrogen heterocycles. Part24. Pyrrolo[3,4-c]isoquinolinone by thermal rearrangement of a pyrrolylbenzotriazinone

1992

Rearrangement under acidic conditions of the pyrrolylbenzotriazinone 7 afforded the pyrrolylbenzamides 10 and 11. By thermal rearrangement instead, the first fully aromatic derivative of the pyrrolo[3,4-c]isoquinoline ring system 9 was obtained.

chemistry.chemical_compoundchemistryBicyclic moleculeOrganic ChemistryThermalLactamchemistry.chemical_elementThermal reactionIsoquinolineRing (chemistry)Medicinal chemistryNitrogenDerivative (chemistry)Journal of Heterocyclic Chemistry
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Darstellung, Kristallstruktur und Wirkung von 2-Methyl-3-(4-oxo-3-phenyl-thiazolidin-2-ylidenamino)-4-(3H)-chinazolinon

1984

Quinazolinones. 1. Preparation, crystal structure and action of 2-methyl-3-(4-oxo-3-phenyl-thiazolidine-2-ylidenamino)-4-(3H)- quinazolinone.

chemistry.chemical_compoundchemistryBicyclic moleculeStereochemistryDrug DiscoveryX-ray crystallographyLactamPharmaceutical ScienceMoleculeBiological activityCrystal structureQuinazolinoneArchiv der Pharmazie
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Synthesis and structural characterization of cis- and trans-fused 4a,5,6,7,8,8a-hexahydro-2H,4H-1,3-benzodithiines and their 2-methyl and 2,2-dimethy…

2002

Both cis- and trans-fused 4a,5,6,7,8,8a-hexahydro-2H,4H-1,3-benzodithiine together with their 2-methyl and 2,2-dimethyl derivatives were prepared as racemates from the appropriate dithiols obtained via multistep syntheses. The products were characterized by 1 H and 13 C NMR, mass spectrometry, and for two of the cis-fused compounds by X-ray diffraction. 1 H, 1 H vicinal coupling constants indicated that all compounds attain chair-chair conformations as their predominant conformations. All three trans-fused isomers exist in totally biased chair-chair conformations and are essentially conformationally locked, whereas the cis-fused compounds are conformationally mobile and can potentially atta…

chemistry.chemical_compoundchemistryBicyclic moleculeStereochemistryOrganic ChemistryX-ray crystallographyDithiolMoleculeCarbon-13 NMRChemical synthesisConformational isomerismCis–trans isomerismThe Journal of organic chemistry
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Reaktivitäut und reaktionswege von methylsubstituierten bisindolylcarbenium-ionen

1987

Methyl substituted bisindolylcarbenium ions 1 react with some O- and C-nucleophiles regioselectively. The cations 1b, 1c yield with hydroxide ions the tetraindolyldimethyl ether 4 and with methoxide ions the bisin-dolylmethoxymethanes 5. Compounds 1a, 1b, 1c react with several methylindoles to isomeric bis- and trisin-dolylmethanes. An electrophilic reactivity order of cations 1 can be derived supporting on the experimental results.

chemistry.chemical_compoundchemistryBicyclic moleculeYield (chemistry)Organic ChemistryElectrophileHydroxideReactivity (chemistry)EtherMethoxideCarbocationPhotochemistryMedicinal chemistryJournal of Heterocyclic Chemistry
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Studien zum Vorgang der Wasserstoffübertragung, 41. Elektroreduktion von Acetophenon unter Mitwirkung optisch aktiver Leitsalze

1977

Die Anderung des Carbinol/Pinakol-Verhaltnisses2) (C/P) und der optischen Induktion bei der Elektroreduktion von Acetophenon mit (1 R, 2S)-N-(3-Cyanpropyl)-N-methylephedriniumbromid (1) und (1 R, 2 S)-N,N-Dimethylephedriniumbromid (2) als Leitsalze wird untersucht in Abhangigkeit: a) vom Potential (Tabelle 1), b) von der Stromdichte (Tabelle 2), c) von Pulsbedingungen (Tabelle 3), d) vom pH (Tabelle 4), e) von der Anwesenheit anderer Kationen (Tabelle 5), f) vom Losungsmittel (Tabelle 6), g) von der Temperatur (Tabelle 7) und h) von der Art des Elektrodenmaterials (Tabelle 8). — Es werden tensammetrische und cyclovoltammetrische Messungen durchgefuhrt. Die in trockenem Dimethylformamid erha…

chemistry.chemical_compoundchemistryBromideSupporting electrolyteOrganic ChemistryHydrogen transferDimethylformamidePhysical and Theoretical ChemistryOptically activeCyclic voltammetryMedicinal chemistryAcetophenoneJustus Liebigs Annalen der Chemie
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