Search results for "cyclopentadiene"

showing 10 items of 49 documents

Origin of the synchronicity in bond formation in polar Diels-Alder reactions: an ELF analysis of the reaction between cyclopentadiene and tetracyanoe…

2012

[EN] The origin of the synchronicity in C-C bond formation in polar Diels-Alder (P-DA) reactions involving symmetrically substituted electrophilic ethylenes has been studied by an ELF analysis of the electron reorganization along the P-DA reaction of cyclopentadiene (Cp) 4 with tetracyanoethylene (TCE) 10 at the B3LYP/6-31G* level. The present study makes it possible to establish that the synchronicity in C-C bond formation in P-DA reactions is controlled by the symmetric distribution of the electron-density excess reached in the electrophile through the charge transfer process, which can be anticipated by an analysis of the spin electron-density at the corresponding radical anion. The ELF …

Pericyclic reactionEthyleneCyclopentadieneINGENIERIA MECANICAOrganic ChemistryElectronTetracyanoethylenePhotochemistryBiochemistryIonchemistry.chemical_compoundchemistryElectrophilePolarPhysical and Theoretical Chemistry
researchProduct

Preparation and Structure of Diexo-Oxanorbornane-fused 1,3-Heterocycles

2004

Via the reaction of diexo-oxanorbornanedicarboxylic anhydride with toluene, the diexo-aroylcarboxylic acid (3a) was prepared, which exists partly as the tautomeric lactol (3b). With bifunctional reagents, 3a yields fused heterocycles containing three-six rings. Thus, alkylenediamines result in imidazole- and 1,3-diazepine-fused oxygen- bridged isoindolones (6a,b), alkanolamines form the oxazole- and 1,3-oxazine-fused oxanorbornene derivatives (7a-c), and o-phenylenediamine undergoes cyclization to furnish the condensed benzimidazole (8). The reaction of 3a with diexo- aminonorbornanecarbohydrazide yields a pyrimidopyridazine containing six condensed rings (9). In a similar reaction with die…

PharmacologyCyclopentadieneLactolArylOrganic ChemistrySubstituentRetro-Diels–Alder reactionMedicinal chemistryTautomerAnalytical Chemistrychemistry.chemical_compoundchemistryInstitut für ChemieOrganic chemistryImidazoleOxazoleHETEROCYCLES
researchProduct

A Chemical Index Inspired by Biological Plastic Evolution:  Valence-Isoelectronic Series of Aromatics

2004

Plastic evolution is a new perspective of the evolutionary process conjugating the effect, on one hand, of the acquired characters and, on the other, of the relationships that emerge among the principle of evolutionary indeterminacy, the principle of morphologic determination, and natural selection. Plastic evolution is applied to design the coordination index Ic. Ic is used to characterize the valence-isoelectronic series of cyclopentadiene, benzene, toluene, and styrene and compared to charge indices for dipole moment. The parameters needed to calculate Ic are minus the standard enthalpy of formation T, molecular surface area S, and molecular weight W. With the exception of the O heteromo…

PhysicsValence (chemistry)CyclopentadieneThermodynamicsGeneral MedicineGeneral ChemistryTolueneStandard enthalpy of formationComputer Science ApplicationsStyreneComputer Science::Hardware Architecturechemistry.chemical_compoundDipoleComputational Theory and MathematicschemistryQuantum mechanicsPhysics::Chemical PhysicsBenzeneTopological quantum numberInformation SystemsJournal of Chemical Information and Computer Sciences
researchProduct

Structure of isotactic polypropylene/ hydrogenated oligo(cyclopentadiene) blends: 1. Polypropylene-rich blends

1998

Blends of isotactic polypropylene (iPP) and hydrogenated oligo(cyclopentadiene) (HOCP) containing 30% or less HOCP have been studied by small-angle X-ray scattering in the temperature range 25 to 160°C. The structure of blends has been analysed in terms of a pseudo two-phase model consisting of stacks of lamellae whose thickness is a function of temperature and composition. Structural parameters of the model have been derived and their temperature and composition dependences have been interpreted in the light of existing theories.

PolypropyleneMaterials scienceCyclopentadienePolymers and PlasticsSmall-angle X-ray scatteringOrganic ChemistryAtmospheric temperature rangeOligomerchemistry.chemical_compoundchemistryChemical engineeringTacticityPolymer chemistryMaterials ChemistryLamellar structurePolymer blendPolymer
researchProduct

A DFT study of the polar Diels–Alder reaction between 4-aza-6-nitrobenzofuroxan and cyclopentadiene

2005

Abstract The polar Diels–Alder reaction between 4-aza-6-nitrobenzofuroxan (ANBF) and cyclopentadiene has been studied using DFT procedures at the B3LYP/6-31G* level. Only one highly asynchronous transition state structure associated to the formation of the [4+2] adduct 13 is found. A further [3,3] sigmatropic shift on the [4+2] cycloadduct 13 allows its conversion into the thermodynamically more stable [2+4] cycloadduct 14 . The analysis of the global and local electrophilicities of the reagents correctly explain the behaviour of ANBF as a strong electrophile in polar cycloadditions.

Reaction mechanismCyclopentadieneChemistryOrganic ChemistrySigmatropic reactionBiochemistryAdductchemistry.chemical_compoundComputational chemistryReagentDrug DiscoveryElectrophilePolarDiels–Alder reactionTetrahedron
researchProduct

A DFT Study of the Molecular Mechanisms of the Diels−Alder Reaction between Cyclopentadiene and 3-Phenyl-1-(2-pyridyl)-2-propen-1-one − Role of the Z…

2002

The molecular mechanism of the Diels−Alder reaction between cyclopentadiene (1) and 3-phenyl-1-(2-pyridyl)-2-propen-1-one (2) in the absence and in the presence of a Zn2+ Lewis acid catalyst has been studied by quantum mechanical calculations at the B3LYP/6-31G* level of theory. A continuum model was selected to represent the effects of the water as solvent. For the uncatalyzed process, two channels, endo and exo, were characterized, and the mechanism corresponded to an asynchronous concerted reaction associated with a [4+2] process. The presence of a Lewis acid catalyst changed the mechanism drastically, the reaction taking place by a polar stepwise mechanism. In the first step, a C−C sigm…

Reaction mechanismCyclopentadieneConcerted reactionOrganic ChemistryMedicinal chemistryFrustrated Lewis pairLewis acid catalysischemistry.chemical_compoundNucleophilechemistryOrganic chemistryLewis acids and basesPhysical and Theoretical ChemistryDiels–Alder reactionEuropean Journal of Organic Chemistry
researchProduct

Understanding the Nature of the Molecular Mechanisms Associated with the Competitive Lewis Acid Catalyzed[4+2] and[4+3] Cycloadditions between Arylid…

2004

The molecular mechanisms of the reactions between aryliden-5(4H)-oxazolone 1, and cyclopentadiene (Cp), in presence of Lewis acid (LA) catalyst to obtain the corresponding [4+2] and [4+3] cycloadducts are examined through density functional theory (DFT) calculations at the B3LYP/6-31G* level. The activation effect of LA catalyst can be reached by two ways, that is, interaction of LA either with carbonyl or carboxyl oxygen atoms of 1 to render [4+2] or [4+3] cycloadducts. The endo and exo [4+2] cycloadducts are formed through a highly asynchronous concerted mechanism associated to a Michael-type addition of Cp to the beta-conjugated position of alpha,beta-unsaturated carbonyl framework of 1.…

Reaction mechanismCyclopentadieneConcerted reactionStereochemistryOrganic ChemistryGeneral ChemistryCatalysisCycloadditionAdductchemistry.chemical_compoundNucleophilechemistryCascade reactionLewis acids and basesChemistry - A European Journal
researchProduct

Unveiling the Ionic Diels-Alder Reactions within the Molecular Electron Density Theory

2021

The ionic Diels–Alder (I-DA) reactions of a series of six iminium cations with cyclopentadiene have been studied within the Molecular Electron Density Theory (MEDT). The superelectrophilic character of iminium cations, ω &gt

Steric effectsCyclopentadienePharmaceutical ScienceIonic bonding010402 general chemistry01 natural sciencesArticleAnalytical Chemistrychemistry.chemical_compoundQD241-441Computational chemistryDrug Discoveryionic Diels–Alder reactionsReactivity (chemistry)Physical and Theoretical Chemistryorganic_chemistry010405 organic chemistryChemistryOrganic ChemistrySolvationCationic polymerizationMolecular Electron Density TheoryIminiumiminium cationsElectron localization function3. Good health0104 chemical sciencesChemistry (miscellaneous)asynchronicityglobal electron density transfersuperelectrophilesMolecular Medicine
researchProduct

A study of the diels-alder reaction of 3-oxabicyclo[3.3.0]oct-1(5)-ene-2,4-dione with cyclopentadiene and some related dienes

1984

Abstract The reaction of 3-oxabicyclo[3.3.0]oct-l(5)ene-2,4-dione, 2, with cyclopentadiene, 3, 5,5-diethoxycyclopentadiene, 4, and 6,6-dimethylfulvene, 5, is studied. Reaction of 2 and 3 yields the expected endo-adduct, while reaction of 2 and 5 gives a mixture of the endo- and exo-adducts whose ratio is slightly dependent on the reaction conditions. Attractive electrostatic interactions in the transition state leading to the exo-adduct can explain the absence of endo stereoselectivity in the last reaction. Steric factors seem to be responsible for the absence of reaction between 2 and 4. The analysis of the 13C NMR spectra of these adducts and some derived compounds confirms the tentative …

Steric effectsOrder of reactionCyclopentadieneBicyclic moleculeStereochemistryOrganic ChemistryBiochemistryMedicinal chemistryElimination reactionchemistry.chemical_compoundchemistryDrug DiscoveryStereoselectivityEne reactionDiels–Alder reactionTetrahedron
researchProduct

Asymmetric synthesis of bicyclic amino acid derivatives by Aza-Diels-Alder reactions in aqueous solution

1991

Derivatives 7–10 and 13–16 of methyl and ethyl 2-azabicyclo[2.2.1]heptane-3-carboxylates are synthesized by Aza-Diels-Alder reactions of chiral iminium ions, formed in situ from glyoxylic acid and chiral amines, with cyclopentadiene. Whereas the heterodienophiles derived from phenylglycinol and esters of sterically more demanding amino acids fail to undergo asymmetric cycloadditions, with alanine methyl ester and (R)-1-phenylethylamine hydrochoride the cycloadducts are formed in yields of 15 and 52%, respectively, reaching de values of up to 90:10 for the exo isomers.

Steric effectschemistry.chemical_classificationCyclopentadieneBicyclic moleculeOrganic ChemistryEnantioselective synthesisIminiumAmino acidchemistry.chemical_compoundchemistryOrganic chemistryAza-Diels–Alder reactionPhysical and Theoretical ChemistryGlyoxylic acidLiebigs Annalen der Chemie
researchProduct