Search results for "cytoprotective"

showing 5 items of 5 documents

Profile of Fatty Acids, Tocopherols, Phytosterols and Polyphenols in Mediterranean Oils (Argan Oils, Olive Oils, Milk Thistle Seed Oils and Nigella S…

2019

Background: The effects of vegetable oils on human health depend on their components. Therefore, their profiles of lipid nutrients and polyphenols were determined. Objective: To establish and compare the fatty acid, tocopherol, phytosterol and polyphenol profiles of Mediterranean oils: cosmetic and dietary argan oils (AO; Morocco: Agadir, Berkane); olive oils (OO; Morocco, Spain, Tunisia); milk thistle seed oils (MTSO; Tunisia: Bizerte, Sousse, Zaghouane); nigella seed oil (NSO). Methods: The biochemical profiles were determined by gas chromatography-flame ionization, high performance liquid chromatography and gas chromatography, coupled with mass spectrometry as required. The antioxidant …

0301 basic medicineAntioxidantmedicine.medical_treatmentLinoleic acidmediterranean oilsTocopherolsAntioxidantsCell LineMice03 medical and health scienceschemistry.chemical_compound0302 clinical medicineDrug DiscoverymedicineAnimalsHumansMilk ThistlePlant OilsFood sciencecytoprotective activitiesOlive OilNigella2. Zero hungerPharmacologybiologyPhytosterolFatty AcidsPhytosterolsPolyphenolsfood and beverages[SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciencesbiology.organism_classificationNigellaantioxidant propertiesOleic acid030104 developmental biologySpinasterolchemistryPolyphenol030220 oncology & carcinogenesisSeedsHydroxytyrosol[SDV.AEN]Life Sciences [q-bio]/Food and NutritionCurrent Pharmaceutical Design
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Cytoprotective Effects of Fish Protein Hydrolysates against H2O2-Induced Oxidative Stress and Mycotoxins in Caco-2/TC7 Cells

2021

Many studies report the potent antioxidant capacity for fish protein hydrolysates, including radical scavenging activity and inhibition ability on lipid peroxidation (LPO). In this study, the in vitro cytotoxicity of protein hydrolysates from different salmon, mackerel, and herring side streams fractions was evaluated in the concentration range from 1 to 1:32 dilution, using cloned human colon adenocarcinoma cells TC7 (Caco-2/TC7) by MTT and PT assays. The protein hydrolysates’ antioxidant capacity and oxidative stress effects were evaluated by LPO and reactive oxygen species (ROS) generation, respectively. The antioxidant capacity for pure and bioavailable hydrolysate fraction was also eva…

0301 basic medicinePhysiologyClinical BiochemistryRM1-950medicine.disease_causeBiochemistryHydrolysateArticleLipid peroxidation03 medical and health scienceschemistry.chemical_compound0404 agricultural biotechnologymedicineoxidative stressFood scienceViability assayCytotoxicityMolecular Biologychemistry.chemical_classificationReactive oxygen species030109 nutrition & dieteticsToxin04 agricultural and veterinary sciencesCell Biology040401 food scienceBioavailabilitychemistrycytoprotective effectcytotoxicityTherapeutics. Pharmacologyfish hydrolysatesbioavailabilityOxidative stressAntioxidants
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Cytoprotective organoselenium compounds for oligodendrocytes

2021

Abstract Herein we report the synthesis of peptide-like and tetrazole-based organoselenium compounds via Ugi and Ugi-azide reactions, respectively. The organoselenium compounds' intrinsic cytoprotective and antioxidant capacities were evaluated in 158 N and 158JP murine oligodendrocytes. Furthermore, their redox properties were theoretically evaluated using Molecular Operating Environment-docking studies. Most of the compounds did not exhibit any cytotoxicity against the 158JP and 158 N cells. Among the tested compounds, the tetrazole- (e.g., 6, 7, and 9) and the pseudopeptide-based organoselenium compounds (e.g., 11, 15, and 17) displayed antioxidant properties. On the other hand, the quin…

AntioxidantCytoprotectiveGeneral Chemical Engineeringmedicine.medical_treatmentOrganoselenium02 engineering and technology010402 general chemistry01 natural sciencesRedoxlcsh:Chemistrychemistry.chemical_compoundOrganoselenium CompoundmedicineTetrazoleCytotoxicityTetrazoleOligodendrocytesGeneral Chemistry021001 nanoscience & nanotechnologyCombinatorial chemistry0104 chemical sciencesUgi reactionchemistrylcsh:QD1-999Antioxidant0210 nano-technologyArabian Journal of Chemistry
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Alternariol-induced cytotoxicity in Caco-2 cells. Protective effect of the phenolic fraction from virgin olive oil.

2014

The extra virgin olive oil (EVOO) has been associated to antioxidant effects. The mycotoxin alternariol (AOH) can contaminate olives. The aims of this work were to determine the cytotoxic effects and reactive oxygen species (ROS) produced by AOH, tyrosol and oleuropein (two polyphenols of olive oil) and a real EVOO extract in Caco-2 cells. The MTT assay and the ROS production by the H2-DCFDA probe were used. Results demonstrated that AOH reduces cellular proliferation depending on concentration, whereas tyrosol and oleuropein did not (12.5-100 μM). The combination of AOH + oleuropein (50 μM) increased cell proliferation (24%) whereas, AOH + tyrosol decreased (47%) it. Besides, AOH increased…

Antioxidantmedicine.medical_treatmentAlternariolAlternariol; Caco-2 cells; Cytotoxic and cytoprotective effect; Extra virgin olive oil; Phenolic compounds; ROS generationTetrazolium SaltsToxicologychemistry.chemical_compoundLactonesPhenolsOleuropeinExtra virgin olive oilmedicineHumansPlant OilsMTT assayPhenolsOlive OilCell Proliferationchemistry.chemical_classificationReactive oxygen speciesAnalysis of VariancePlant ExtractsPhenolic compoundsTyrosolAlternariolThiazoleschemistryBiochemistryPolyphenolROS generationCaco-2 CellsReactive Oxygen SpeciesCytotoxic and cytoprotective effectToxicon : official journal of the International Society on Toxinology
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Levels of thrombopoietin in aqueous humor of patients with noninfectious acute anterior uveitis

2015

José-Juan Mondejar,1,4 David Salom,1,3 Salvador Garcia-Delpech,1,2 Manuel Diaz-Llopis11Ophthalmology Department, School of Medicine, University of Valencia, 2Ophthalmology Department, Hospital Universitario La Fe, 3Ophthalmology Department, Hospital de Manises, Valencia, 4Ophthalmology Department, Hospital General Universitario de Alicante, Alicante, SpainPurpose: To measure thrombopoietin (TPO) levels in the serum and aqueous humors of patients with noninfectious acute anterior uveitis.Methods: A prospective, comparative, controlled study. Serum and aqueous humors were obtained from the eyes of 16 patients with noninfectious acute anterior uveitis. TPO levels were measu…

medicine.medical_specialtyAqueous humorTPOfluids and secretionsOphthalmologyMedicinethrombopoietinIndependent dataTissue homeostasisThrombopoietinOriginal ResearchRepair processescytoprotectivebusiness.industryacute anterior uveitisfood and beveragesClinical Ophthalmologyaqueous humorsmedicine.diseasehumanitieseye diseasesOphthalmologyACUTE ANTERIOR UVEITISembryonic structuresAnterior uveitissense organsbusinessserumUveitisClinical Ophthalmology (Auckland, N.Z.)
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