Search results for "d-a"

Activity-Dependent Regulation of Neuronal Apoptosis in Neonatal Mouse Cerebral Cortex

2007

A massive neuronal loss during early postnatal development has been well documented in the murine cerebral cortex, but the factors that drive cells into apoptosis are largely unknown. The role of neuronal activity in developmental apoptosis was studied in organotypic neocortical slice cultures of newborn mice. Multielectrode array and whole-cell patch-clamp recordings revealed spontaneous network activity characterized by synchronized burst discharges, which could be blocked by tetrodotoxin and ionotropic glutamate receptor antagonists. The identical neuropharmacological manipulations also caused a significant increase in the number of apoptotic neurons as early as 6 h after the start of dr…

Ultrasound-assisted green solvent extraction of high-added value compounds from microalgae Nannochloropsis spp.

2015

Abstract The aim of this work was to investigate ultrasound (US)-assisted green solvent extraction of valuable compounds from the microalgae Nannochloropsis spp. Individual green solvents (water, ethanol (EtOH), dimethyl sulfoxide (DMSO)) and binary mixture of solvents (water-DMSO and water-EtOH) were used for the extraction procedures. Maximum total phenolic compounds yield ( Y p  ≈ 0.33) was obtained after US pre-treatment ( W  = 400 W, 15 min), being almost 5-folds higher compared to that found for the untreated samples and aqueous extraction ( Y p  ≈ 0.06). The highest yield of total chlorophylls ( Y c  ≈ 0.043) was obtained after US ( W  = 400 W, 7.5 min), being more than 9-folds highe…

Exploring the binding of Pt drugs to gold nanoparticles for controlled passive release of cisplatin.

2011

Preclinical models for colonic absorption, application to controlled release formulation development.

2018

Oral controlled release (CR) formulations have many benefits and have become a valuable resource for the local and systemic administration of drugs. The most important characteristic of these pharmaceutical products is that drug absorption occurs mainly in the colon. Therefore, this review analyses the physiological and physicochemical features that may affect an orally administered CR product, as well as the different strategies to develop a CR dosage form and the methods used to evaluate the formulation efficacy. The models available to study the intestinal permeability and their applicability to colonic permeability determinations are also discussed.

MR imaging of bilateral paramedian thalamic and mesencephalic infarcts: A case report

2010

We describe MR imaging of bilateral infarction of the paramedian portion of the mesencephalus and thalamus due to an occlusion of the Percheron artery. This entity is due to one of the anatomic variants of the perforating arteries supplying the thalamus and mesenchephalus. Clinically this kind of infarction presents with neurologic impairment as a disorder of consciousness, memory dysfunctions, various types of vertical gaze palsy and psychic changes, which need to be differentiated from delirium and coma. At MRI evaluation infarction of the paramedian portion of thalami and midbrain, with a “butterfly wings” pattern, was demonstrated as high signal intensity areas on FLAIR and FSE-T2W ima…

Crowd-Averse Cyber-Physical Systems: The Paradigm of Robust Mean-Field Games

2016

For a networked controlled system, we illustrate the paradigm of robust mean-field games. This is a modeling framework at the interface of differential game theory, mathematical physics, and $H_{\infty}$ - optimal control that tries to capture the mutual influence between a crowd and its individuals. First, we establish a mean-field system for such games including the effects of adversarial disturbances. Second, we identify the optimal response of the individuals for a given population behavior. Third, we provide an analysis of equilibria and their stability.

Touch or touchless?:Evaluating usability of interactive displays for persons with autistic spectrum disorders

2019

Interactive public displays have been exploited and studied for engaging interaction in several previous studies. In this context, applications have been focused on supporting learning or entertainment activities, specifically designed for people with special needs. This includes, for example, those with Autism Spectrum Disorders (ASD). In this paper, we present a comparison study aimed at understanding the difference in terms of usability, effectiveness, and enjoyment perceived by users with ASD between two interaction modalities usually supported by interactive displays: touch-based and touchless gestural interaction. We present the outcomes of a within-subject setup involving 8 ASD users…

Strain, doping and electronic transport of large area monolayer MoS2 exfoliated on gold and transferred to an insulating substrate

2021

Gold-assisted mechanical exfoliation currently represents a promising method to separate ultra-large (cm-scale) transition metal dichalcogenides (TMDs) monolayers (1L) with excellent electronic and optical properties from the parent van der Waals (vdW) crystals. The strong interaction between $Au$ and chalcogen atoms is the key to achieve this nearly perfect 1L exfoliation yield. On the other hand, it may affect significantly the doping and strain of 1L TMDs in contact with Au. In this paper, we systematically investigated the morphology, strain, doping, and electrical properties of large area 1L $MoS_{2}$ exfoliated on ultra-flat $Au$ films ($0.16-0.21 nm$ roughness) and finally transferre…

A Simple Operating Strategy of Small-Scale Battery Energy Storages for Energy Arbitrage under Dynamic Pricing Tariffs

2015

Price arbitrage involves taking advantage of an electricity price difference, storing electricity during low-prices times, and selling it back to the grid during high-prices periods. This strategy can be exploited by customers in presence of dynamic pricing schemes, such as hourly electricity prices, where the customer electricity cost may vary at any hour of day, and power consumption can be managed in a more flexible and economical manner, taking advantage of the price differential. Instead of modifying their energy consumption, customers can install storage systems to reduce their electricity bill, shifting the energy consumption from on-peak to off-peak hours. This paper develops a deta…

Investigation of the Temperature Sensitivity of 20-Years Old Field-Aged Photovoltaic Panels Affected by Potential Induced Degradation

2022

One effect of moisture ingress on solar panels is potential induced degradation (PID). Solar panels affected by PID experience large leakage currents between the solar cells and the module’s frame, which leads to substantial power degradation. In the present work, the temperature coefficients of 3 old PV panels affected by PID were investigated. In the electroluminescence images, solar cells nearer to the edge of the modules appear darker due to ohmic shunting. IR thermal images acquired under clear sky outdoor conditions show that the majority of the warmer cells (hotspots) were located closer to the edge of the modules. The difference in cell temperature (∆T) due to PID effect…