Search results for "dab"
showing 10 items of 1280 documents
BRAF as a positive predictive biomarker: Focus on lung cancer and melanoma patients
2020
In the era of personalized medicine, BRAF mutational assessment is mandatory in advanced-stage melanoma and non-small cell lung cancer (NSCLC) patients. The identification of actionable mutations is crucial for the adequate management of these patients. To date various drugs have been implemented in clinical practice. Similarly, various methods may be adopted for the identification of BRAF mutations. Here, we briefly review the current literature on BRAF in melanoma and NSCLC, focusing attention in particular on the different methods and drugs adopted in these patients. In addition, an overview of the real-world practice in different Italian laboratories with high expertise in molecular pre…
Influence of the Fabrication Accuracy of Hot-Embossed PCL Scaffolds on Cell Growths
2020
Polycaprolactone (PCL) is a biocompatible and biodegradable polymer widely used for the realization of 3D scaffold for tissue engineering applications. The hot embossing technique (HE) allows the obtainment of PCL scaffolds with a regular array of micro pillars on their surface. The main drawback affecting this kind of micro fabrication process is that such structural superficial details can be damaged when detaching the replica from the mold. Therefore, the present study has focused on the optimization of the HE processes through the development of an analytical model for the prediction of the demolding force as a function of temperature. This model allowed calculating the minimum demoldin…
Gap-accepteance parameters for roundabouts: a systematic review
2015
Purpose The critical and follow-up headways are the two gap-acceptance parameters which explain the traffic interaction of a minor street vehicle when enters the roundabout, merging into or crossing one or more circulating (major) streams.Severalstudiesandresearchesprovidemeasurements of critical and follow-up headways from real data at roundabouts. The objective of our research is to synthesize the data from the series of selected studies to interpret variation across the studies. Methods In order to match the research goal, a systematic literaturereviewonestimationsofcriticalandfollow-upheadways at roundabouts was undertaken. Since several studies andresearchesdevelopedworldwidewereexamin…
Surrogate Measures of Safety at Roundabouts in AIMSUN and VISSIM Environment
2018
This paper addresses issues on road safety analysis through microscopic traffic simulation models. The Surrogate Safety Assessment Model (SSAM) was applied to read vehicle trajectory files generated by two micro-simulators and then calculate surrogate measures of safety. Since safety assessment of any road entity can provide different results based on the micro-simulator which is used, the main objective of this research was to estimate the safety performance of three roundabout layouts and compare the conflict events simulated by AIMSUN and VISSIM. The two micro-simulators were used to build the calibrated models of the roundabouts, each fitting the corresponding empirical capacity functio…
Analysis of Kinematic Parameters and Driver Behavior at Turbo Roundabouts
2018
This study focuses on both vehicle kinematic parameters (speed and acceleration) and behavior parameters (critical interval and follow-up time) of drivers at turbo-roundabouts. Empirical evaluations of such parameters can be helpful in calibrating traffic microsimulation models or assigning behavior parameters to closed-form capacity models in turbo-roundabouts (gap-acceptance capacity models) and are also related to evaluation of vehicles pollutant emissions. The research was based on traffic process observed in the first turbo-roundabout implemented in the city of Maribor in Slovenia. In 2016 a great number of traffic samples were taken with high-frame-rate video recordings [>50 frames pe…
Quine’s Fluted Fragment is Non-elementary
2016
We study the fluted fragment, a decidable fragment of first-order logic with an unbounded number of variables, originally identified by W.V. Quine. We show that the satisfiability problem for this fragment has non-elementary complexity, thus refuting an earlier published claim by W.C. Purdy that it is in NExpTime. More precisely, we consider, for all m greater than 1, the intersectionof the fluted fragment and the m-variable fragment of first-order logic. We show that this subfragment forces (m/2)-tuply exponentially large models, and that its satisfiability problem is (m/2)-NExpTime-hard. We round off by using a corrected version of Purdy’s construction to show that the m-variable fluted f…
Readability and the Web
2012
Readability indices measure how easy or difficult it is to read and comprehend a text. In this paper we look at the relation between readability indices and web documents from two different perspectives. On the one hand we analyse how to reliably measure the readability of web documents by applying content extraction techniques and incorporating a bias correction. On the other hand we investigate how web based corpus statistics can be used to measure readability in a novel and language independent way.
Eye Movement Analyses for Obtaining Readability Formula for Latvian Texts for Primary School
2017
To determine the difficulty of text, readability formulas can be used. The research was made to find readability formula for Latvian. Readability formulas for English were used as guidelines. The novelty was the use of eye movement tracking during reading to obtain quantitative data that lead to readability formula. Eye fixation durations were gathered during readability measurements. Average values of fixation durations were calculated to characterize texts and readers. 15 texts with various difficulty levels were composed for exposing them to readers. More than 300 children of grades 1 - 4 were participating in measurements. Average values of eye fixation durations of readers from a certa…
Lauku skolas ārējās vides izmantošana dabaszinību apguvē 1. klasē
2022
Covid pandēmija aktualizēja āra nodarbību nepieciešamību un iespējas. Lauku skolu atrašanās tuvāk dabai ir būtiska iespēja efektīvai dabaszinību apguvei 1. klasē. Pētījuma mērķis: izpētīt āra vides veidošanu un izmantošanu lauku skolās dabaszinību apguvē 1. klasē. Pētījuma uzdevumi - 1. klases vecuma, dabaszinību pasniegšanas un āra nodarbību teorētisko un praktisko aspektu izpēte. Pētījuma atziņas: nodarbības āra vidē ir ar pozitīvu ietekmi uz bērnu uzvedību, ja sagatavotas interesanti; mācīšanās ārā Covid kontekstā bija normatīvi noteikta kā epidemioloģiski drošības pasākumi. Dabaszinību apguves āra vidē ieguvumi ir - dabaszinību sasaiste ar reālo dzīvi; radošums; labāka imunitāte. Būtisk…
A Tool to Assess Architectural Education from the Sustainable Development Perspective and the Students' Viewpoint
2021
[EN] Architectural education plays a fundamental role in achieving sustainable development by training future professionals who can contribute to sustainability through their practice. Nevertheless, to ensure the introduction of sustainable development in the education of future architects, it is fundamental to understand what is being done and what could be improved. Despite this, a big gap has been detected in the assessment of architectural education in Spain and worldwide. Thus, a close-ended questionnaire for students has been designed based on the outcomes from a literature review, exploratory interviews with specialists, and the qualitative analysis of two schools of architecture. Ad…