Search results for "database."
showing 10 items of 2119 documents
Principal component analysis on molecular descriptors as an alternative point of view in the search of new Hsp90 inhibitors
2009
Inhibiting a protein that regulates multiple signal transduction pathways in cancer cells is an attractive goal for cancer therapy. Heat shock protein 90 (Hsp90) is one of the most promising molecular targets for such an approach. In fact, Hsp90 is a ubiquitous molecular chaperone protein that is involved in folding, activating and assembling of many key mediators of signal transduction, cellular growth, differentiation, stress-response and apoptothic pathways. With the aim to analyze which molecular descriptors have the higher importance in the binding interactions of these classes, we first performed molecular docking experiments on the 187 Hsp90 inhibitors included in the BindingDB, a pu…
Nursing interventions of choice for the prevention and treatment of suicidal behaviour: The umbrella review protocol
2022
Abstract Aim To determine which interventions, from a nursing perspective, can be considered as the interventions of choice for the prevention and treatment of suicidal behaviour. In this way, the umbrella review attempts to identify nursing interventions from the Nursing Interventions Classification (NIC) taxonomy with evidence for this purpose. Design Descriptive study protocol. Methods This umbrella review will consist of an extensive, systematic search of published systematic reviews and meta‐analyses of studies examining interventions of choice for the prevention and treatment of suicidal behaviour. A systematic search of papers indexed in PubMed, CINAHL, Cochrane Database of Systemati…
Definitions and measurement of health literacy in health and medicine research: a systematic review
2022
ObjectivesThe way health literacy is understood (conceptualised) should be closely linked to how it is measured (operationalised). This study aimed to gain insights into how health literacy is defined and measured in current health literacy research and to examine the relationship between health literacy definitions and instruments.DesignSystematic review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement.Data sourcesThe MEDLINE, PsycINFO, ERIC and CINAHL databases were searched for articles published during two randomly selected months (March and October) in 2019.Eligibility criteriaWe included articles with a quantitative design that measur…
Exudate-based diabetic macular edema detection in fundus images using publicly available datasets
2010
International audience; Diabetic macular edema (DME) is a common vision threatening complication of diabetic retinopathy. In a large scale screening environment DME can be assessed by detecting exudates (a type of bright lesions) in fundus images. In this work, we introduce a new methodology for diagnosis of DME using a novel set of features based on colour, wavelet decomposition and automatic lesion segmentation. These features are employed to train a classifier able to automatically diagnose DME through the presence of exudation. We present a new publicly available dataset with ground-truth data containing 169 patients from various ethnic groups and levels of DME. This and other two publi…
An open-source computational and data resource to analyze digital maps of immunopeptidomes
2015
We present a novel mass spectrometry-based high-throughput workflow and an open-source computational and data resource to reproducibly identify and quantify HLA-associated peptides. Collectively, the resources support the generation of HLA allele-specific peptide assay libraries consisting of consensus fragment ion spectra, and the analysis of quantitative digital maps of HLA peptidomes generated from a range of biological sources by SWATH mass spectrometry (MS). This study represents the first community-based effort to develop a robust platform for the reproducible and quantitative measurement of the entire repertoire of peptides presented by HLA molecules, an essential step towards the de…
Narrow-diameter implants: A systematic review and meta-analysis.
2018
OBJECTIVES Narrow-diameter implants (NDI) are claimed to be a reasonable alternative to bone augmentation procedures. The aim of this comprehensive literature review was to conduct a meta-analysis comparing the implant survival of NDI and standard diameter implants (SDI) and to provide recommendations and guidelines for application of NDI. MATERIAL AND METHODS An extensive systematic literature search was performed in the PubMed/MEDLINE and the Cochrane Library databases. NDI were classified into Category 1 (implant diameter <3.0 mm, "mini-implants"), Category 2 (implant diameter 3-3.25 mm) and Category 3 (implant diameters 3.3-3.5 mm). Clinical studies at all levels of evidence with at lea…
Increasing the Coverage of Medicinal Chemistry-Relevant Space in Commercial Fragments Screening
2014
Analyzing the chemical space coverage in commercial fragment screening collections revealed the overlap between bioactive medicinal chemistry substructures and rule-of-three compliant fragments is only ∼25%. We recommend including these fragments in fragment screening libraries to maximize confidence in discovering hit matter within known bioactive chemical space, while incorporation of nonoverlapping substructures could offer novel hits in screening libraries. Using principal component analysis, polar and three-dimensional substructures display a higher-than-average enrichment of bioactive compounds, indicating increasing representation of these substructures may be beneficial in fragment …
Using databases to improve the visibility of women’s contributions in STEM fields
2021
Las bases de datos son herramientas muy poderosas para simplificar la gestión y el acceso a la información, que han demostrado ser capacidades fundamentales en la era de la ciencia de datos. Actualmente, las bases de datos se utilizan ampliamente en muchas aplicaciones y campos diferentes. En este trabajo destacamos los beneficios que pueden aportar las bases de datos disponibles públicamente de mujeres profesionales que trabajan en los campos de la Ciencia, la Tecnología, la Ingeniería y las Matemáticas (CTIM) para superar el problema de la falta de diversidad y equidad de género en estos campos. Algunos ejemplos de bases de datos públicas en España se presentan en este trabajo. Se hace es…
Comparison of SQL Servers
2010
Šajā darbā apskatīti Microsoft SQL 2000, Microsoft SQL 2005 un Microsoft SQL 2008 serveri, veikta to vispārīgā un ātrdarbības salīdzināšana. Rezultātā tika noskaidrots, ka vairākums gadījumos Microsft SQL 2008 ir ātrāks par abiem pārējiem Microsoft SQL serveriem un tā funkcionalitāte ievērojami palīdz SQL pieprasījumu veidošanā.
Advanced Topics in Intelligent Information and Database Systems
2017
This book presents recent research in intelligent information and database systems. The carefully selected contributions were initially accepted for presentation as posters at the 9th Asian Conference on Intelligent Information and Database Systems (ACIIDS 2017) held from to 5 April 2017 in Kanazawa, Japan. While the contributions are of an advanced scientific level, several are accessible for non-expert readers. The book brings together 47 chapters divided into six main parts: • Part I. From Machine Learning to Data Mining.• Part II. Big Data and Collaborative Decision Support Systems,• Part III. Computer Vision Analysis, Detection, Tracking and Recognition,• Part IV. Data-Intensive Text P…