Search results for "ddc:6"

showing 10 items of 788 documents

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

2016

Seuls les 100 premiers auteurs dont les auteurs INRA ont été entrés dans la notice. La liste complète des auteurs et de leurs affiliations est accessible sur la publication.; International audience; In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues…

[SDV]Life Sciences [q-bio]autophagosomeReview Articleddc:616.07stressstreLC3MESH: AnimalsSettore MED/49 - Scienze Tecniche Dietetiche ApplicateSettore BIO/06 - Anatomia Comparata E Citologiachaperone-mediated autophagyComputingMilieux_MISCELLANEOUSSettore BIO/11Pharmacology. TherapySettore BIO/13standards [Biological Assay]autolysosomeMESH: Autophagy*/physiologylysosomemethods [Biological Assay]Biological AssaySettore BIO/17 - ISTOLOGIAErratumHumanBiochemistry & Molecular BiologySettore BIO/06physiology [Autophagy]Chaperonemediated autophagy[SDV.BC]Life Sciences [q-bio]/Cellular BiologyNOautophagy guidelines molecular biology ultrastructureautolysosome; autophagosome; chaperone-mediated autophagy; flux; LC3; lysosome; macroautophagy; phagophore; stress; vacuoleMESH: Biological Assay/methodsMESH: Computer Simulationddc:570Autolysosome Autophagosome Chaperonemediated autophagy Flux LC3 Lysosome Macroautophagy Phagophore Stress VacuoleAutophagyAnimalsHumansComputer SimulationSettore BIO/10ddc:612BiologyphagophoreMESH: HumansvacuoleAnimalLC3; autolysosome; autophagosome; chaperone-mediated autophagy; flux; lysosome; macroautophagy; phagophore; stress; vacuole; Animals; Biological Assay; Computer Simulation; Humans; Autophagy0601 Biochemistry And Cell BiologyfluxmacroautophagyMESH: Biological Assay/standards*Human medicineLC3; autolysosome; autophagosome; chaperone-mediated autophagy; flux; lysosome; macroautophagy; phagophore; stress; vacuole
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Equivalence of Open-Loop and Closed-Loop Operation of SAW Resonators and Delay Lines

2019

International audience; Surface acoustic wave (SAW) sensors in the form of two-port resonators or delay lines are widely used in various fields of application. The readout of such sensors is achieved by electronic systems operating either in an open-loop or in a closed-loop configuration. The mode of operation of the sensor system is usually chosen based on requirements like, e.g., bandwidth, dynamic range, linearity, costs, and immunity against environmental influences. Because the limit of detection (LOD) at the output of a sensor system is often one of the most important figures of merit, both readout structures, i.e., open-loop and closed-loop systems, are analyzed in terms of the minim…

[SPI.OTHER]Engineering Sciences [physics]/OtherPhysics - Instrumentation and DetectorsComputer scienceddc:621.3ResonatorPhase NoiseFOS: Physical sciencesSAW sensorslcsh:Chemical technology01 natural sciencesBiochemistryArticleAnalytical Chemistryfrequency detectionResonator0103 physical sciencesPhase noiseElectronic engineeringreadout systemsFigure of meritddc:6lcsh:TP1-1185[PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det]Electrical and Electronic EngineeringReadout Systems010301 acousticsInstrumentationDelay LineDynamic rangeFrequency Detection010401 analytical chemistryBandwidth (signal processing)Surface acoustic waveOpen-loop controllerarticlePhase DetectionLinearityInstrumentation and Detectors (physics.ins-det)Open-loop Vs. Closed-loopdelay lineAtomic and Molecular Physics and Opticsphase noise0104 chemical sciencesSaw Sensorsopen-loop vs. closed-loopresonatorPhase-sensitive Sensorsphase detectionphase-sensitive sensors
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Soft tissue integration of different abutment surfaces: An experimental study with histological analysis

2021

OBJECTIVE To evaluate whether abutment surface and surface bio-activation have an effect on soft tissue morphogenesis. MATERIALS AND METHODS 36 patients (36 implants) were included. Abutments were randomly divided into 4 groups (n = 9): Smooth Surface-MAChined (MAC), Ultrathin Threaded Microsurface (UTM), MAC Plasma of Argon activated (Plasma-MAC), and UTM Plasma of Argon activated (Plasma-UTM). After 2 months of healing, soft tissue samples were collected and prepared for histological analysis. The margin of the peri-implant mucosa (PM), the apical extension of the barrier epithelium (aJE), and the apical location of the abutment (AM) were identified. Significances of differences among gro…

abutment0206 medical engineeringAbutmentConnective tissueDentistryPlasma treatmentDental Abutments02 engineering and technologyperi-implant attachmentsoft tissue adaptation03 medical and health sciences0302 clinical medicinebiologic widthmedicineHumansArgonDental ImplantsTitaniumbusiness.industryChemistryDental Implantation EndosseousSoft tissue030206 dentistry020601 biomedical engineeringEpitheliumddc:617.6Dental Implantationmedicine.anatomical_structureConnective Tissuetransmucosal collarOral Surgeryabutment; biologic width; peri-implant attachment; soft tissue adaptation; transmucosal collarbusinessEndosseousTooth
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Enhancing Resilience of Boreal Forests Through Management Under Global Change: a Review

2022

Abstract Purpose of Review Boreal forests provide a wide range of ecosystem services that are important to society. The boreal biome is experiencing the highest rates of warming on the planet and increasing demand for forest products. Here, we review how changes in climate and its associated extreme events (e.g., windstorms) are putting at risk the capacity of these forests to continue providing ecosystem services. We further analyze the role of forest management to increase forest resilience to the combined effects of climate change and extreme events. Recent Findings Enhancing forest resilience recently gained a lot of interest from theoretical perspective. Yet, it remains unclear how to …

adaptive managementforest managementsilvicultureilmastonmuutoksetmetsätbiodiversiteettiddc:ekosysteemit (ekologia)ecological modelingilmastoddc:630socio-economic conditionsPharmacology (medical)metsänhoitososioekonomiset tekijätbiodiversityCurrent Landscape Ecology Reports
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The importance of the insular cortex for vestibular and spatial syndromes.

2020

BACKGROUND AND PURPOSE The aim of the study was to identify the neuroanatomical correlates and associations of neuropsychological syndromes after acute unilateral right-hemisphere brain lesions. The neuropsychological syndromes considered were orientation in three-dimensional space such as tilts of the subjective visual vertical or of the subjective haptic vertical, pusher syndrome, visual neglect and unawareness of paresis (anosognosia for hemiparesis). These neuropsychological phenomena have been found to occur separately or in different combinations after lesions to the right insular cortex. METHOD Magnetic resonance imaging scans were obtained from 82 patients with acute right-hemispher…

anosognosia for hemiparesisInsular cortexinsulaFunctional LateralityPerceptual Disorders03 medical and health sciences0302 clinical medicineOrientation (mental)diagnostic imaging [Cerebral Cortex]medicinediagnostic imaging [Stroke]Humans030212 general & internal medicineddc:610StrokeVestibular systemCerebral Cortexbusiness.industryAnosognosianeglectNeuropsychologySyndromemedicine.diseaseMagnetic Resonance ImagingStrokeHemiparesisNeurologypusher syndromeetiology [Perceptual Disorders]Neurology (clinical)medicine.symptombusinessInsulaNeurosciencesubjective visual and haptic vertical030217 neurology & neurosurgery
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Synthesis of N‐Fused Indolines via Copper (II)‐Catalyzed Dearomatizing Cyclization of Indoles

2021

Advanced synthesis & catalysis 363(12), 3121-3126 (2021). doi:10.1002/adsc.202100290

aromaattiset yhdisteetkemiallinen synteesi660Chemistrychemistry.chemical_elementkupariGeneral ChemistryMedicinal chemistryCopperCatalysischemistry.chemical_compoundkatalyysiIndolineddc:660orgaaniset yhdisteet
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Comparison between simulated and observed LHC beam backgrounds in the ATLAS experiment at E beam =4 TeV

2018

Results of dedicated Monte Carlo simulations of beam-induced background (BIB) in the ATLAS experiment at the Large Hadron Collider (LHC) are presented and compared with data recorded in 2012. During normal physics operation this background arises mainly from scattering of the 4 TeV protons on residual gas in the beam pipe. Methods of reconstructing the BIB signals in the ATLAS detector, developed and implemented in the simulation chain based on the FLUKA Monte Carlo simulation package, are described. The interaction rates are determined from the residual gas pressure distribution in the LHC ring in order to set an absolute scale on the predicted rates of BIB so that they can be compared qua…

background [beam]background: inducedPhysics::Instrumentation and DetectorsCiencias FísicasMonte Carlo method01 natural sciencesHigh Energy Physics - ExperimentSubatomär fysik//purl.org/becyt/ford/1 [https]High Energy Physics - Experiment (hep-ex)beam lossesSubatomic Physicsscattering [p p][PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex]and programsInstrumentationQCMathematical PhysicsPhysicsLarge Hadron ColliderRadiation calculationsAtlas (topology)Accelerator modelling and simulations (multi-particle dynamics; single-particle dynamics)DetectorATLAS experimentSettore FIS/01 - Fisica SperimentaleSimulation methods and programBeams (radiation) Accelerator modelling and simulations (multi-particle dynamics;; single-particle dynamics); Radiation calculations; Simulation methods; and programs; DETECTOR; SEARCHObservableAccelerator modelling and simulations (multi-particle dynamicMonte Carlo [numerical calculations]ATLASNuclear & Particles PhysicsAccelerator modelling and simulationsCERN LHC Coll collimators beam: backgroundcolliding beams [p p]numerical calculations: Monte CarloCIENCIAS NATURALES Y EXACTASParticle Physics - Experimentp p: scatteringAccelerator modelling and simulations (multi-particle dynamics; Radiation calculations; Simulation methods and programs; single-particle dynamics); Instrumentation; Mathematical Physics530 PhysicsCiências Naturais::Ciências Físicas:Ciências Físicas [Ciências Naturais]FOS: Physical sciencesFísica de Partículas y CamposAccelerator Physics and InstrumentationNuclear physicsFLUKAsingle-particle dynamics)ATLAS LHC High Energy PhysicsHIGH ENERGY PHYSICSSEARCH0103 physical sciencesddc:610010306 general physicsAbsolute scaleDETECTORpressure [gas]Science & Technology010308 nuclear & particles physicsScatteringhep-exRadiation calculationscatteringAcceleratorfysik och instrumentering//purl.org/becyt/ford/1.3 [https]ghostAccelerator modelling and simulations (multi-particle dynamicsSimulation methodscorrelationinduced [background]Experimental High Energy Physicsgas: pressureSimulation methods and programsp p: colliding beamsexperimental results
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Domain‐specific neural networks improve automated bird sound recognition already with small amount of local data

2022

1. An automatic bird sound recognition system is a useful tool for collecting data of different bird species for ecological analysis. Together with autonomous recording units (ARUs), such a system provides a possibility to collect bird observations on a scale that no human observer could ever match. During the last decades, progress has been made in the field of automatic bird sound recognition, but recognizing bird species from untargeted soundscape recordings remains a challenge. 2. In this article, we demonstrate the workflow for building a global identification model and adjusting it to perform well on the data of autonomous recorders from a specific region. We show how data augmentatio…

bio-monitoringeläinten äänetEcological ModelingMODELSautonomous recording unitsdeep learningsyväoppiminenneuroverkotbird sound recognitionRECORDERSddc:bioacousticshavainnotkoneoppiminen1181 Ecology evolutionary biologyconvolutional neural networksmodel fine-tuninglinnutddc:630tunnistaminenEcology Evolution Behavior and Systematics
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Modular Breath Analyzer (MBA): Introduction of a Breath Analyzer Platform Based on an Innovative and Unique, Modular eNose Concept for Breath Diagnos…

2021

Exhaled breath analysis for early disease detection may provide a convenient method for painless and non-invasive diagnosis. In this work, a novel, compact and easy-to-use breath analyzer platform with a modular sensing chamber and direct breath sampling unit is presented. The developed analyzer system comprises a compact, low volume, temperature-controlled sensing chamber in three modules that can host any type of resistive gas sensor arrays. Furthermore, in this study three modular breath analyzers are explicitly tested for reproducibility in a real-life breath analysis experiment with several calibration transfer (CT) techniques using transfer samples from the experiment. The experiment …

calibration transferComputer scienceRespiratory SystemPharmaceutical ScienceOrganic chemistrycorrelation alignment01 natural scienceseNoseAnalytical Chemistry0302 clinical medicineQD241-441DDC 570 / Life sciencesDrug Discoverybreath analysisSensortechnikdigestive oral and skin physiologyAtemgasanalyseMischoxideExhalationChemistry (miscellaneous)piecewise direct standardization030220 oncology & carcinogenesisElektronische NaseCalibrationMolecular MedicineMOX sensorsSpectrum analyzerAdolescentlow sensing chamber volumeReal-time computingstandard samplesbreath samplingArticleElectronic nose03 medical and health sciencesddc:570Breath testsCalibrationHumansddc:610Physical and Theoretical ChemistryReproducibilitybusiness.industry010401 analytical chemistryBreath samplingpattern recognitionBreath diagnosticsAtemluftModular design0104 chemical sciencesBreath analyzerBreath gas analysisbusinessBiosensing techniquesDDC 610 / Medicine & healthBiomarkersMolecules
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No Difference in Penetrance between Truncating and Missense/Aberrant Splicing Pathogenic Variants in MLH1 and MSH2: A Prospective Lynch Syndrome Data…

2021

Background. Lynch syndrome is the most common genetic predisposition for hereditary cancer. Carriers of pathogenic changes in mismatch repair (MMR) genes have an increased risk of developing colorectal (CRC), endometrial, ovarian, urinary tract, prostate, and other cancers, depending on which gene is malfunctioning. In Lynch syndrome, differences in cancer incidence (penetrance) according to the gene involved have led to the stratification of cancer surveillance. By contrast, any differences in penetrance determined by the type of pathogenic variant remain unknown. Objective. To determine cumulative incidences of cancer in carriers of truncating and missense or aberrant splicing pathogenic …

cancer incidence0302 clinical medicineMalalties hereditàriesMissense mutation8Q23.3CàncerCancerGenetics0303 health sciencesmedicine.diagnostic_testFactors de risc en les malaltiesMISMATCH REPAIR GENESRMLH1General MedicinePenetranceLynch syndrome3. Good healthsyöpägeenit030220 oncology & carcinogenesisMedicinesyöpätauditilmaantuvuusGenetic diseasescongenital hereditary and neonatal diseases and abnormalitiesmissense11Q23.1Risk factors in diseasesCANCER-RISKMLH1Articleaberrant splicing03 medical and health sciencesAGEmedicineGenetic predispositionddc:610<i>MSH2</i>Lynchin oireyhtymäpenetrance030304 developmental biologyGenetic testingMLH1; MSH2; penetrance; cancer incidence; truncating; missense; aberrant splicing; Lynch syndromeperinnölliset tauditbusiness.industryMUTATIONSHMSH2Cancernutritional and metabolic diseasesmedicine.diseasedigestive system diseasesMSH2Lynch syndromeMSH23121 General medicine internal medicine and other clinical medicine<i>MLH1</i>businesstruncating
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