Search results for "ddc:"
showing 10 items of 3080 documents
The relationship between context, structure, and processes with outcomes of 6 regional diabetes networks in Europe
2018
BackgroundWhile health service provisioning for the chronic condition Type 2 Diabetes (T2D) often involves a network of organisations and professionals, most evidence on the relationships between the structures and processes of service provisioning and the outcomes considers single organisations or solo practitioners. Extending Donabedian's Structure-Process-Outcome (SPO) model, we investigate how differences in quality of life, effective coverage of diabetes, and service satisfaction are associated with differences in the structures, processes, and context of T2D services in six regions in Finland, Germany, Greece, Netherlands, Spain, and UK.MethodsData collection consisted of: a) systemat…
Equal access to the top? Measuring selection into finnish academia
2019
In this article, we draw a parallel between equality of opportunity in educational transitions and equality of opportunity in academic careers. In both cases, many methodological problems can be ameliorated by the use of longitudinal rather than cross-sectional data. We illustrate this point by using Finnish full-population register data to follow the educational and academic careers of the 1964–1966 birth cohorts from birth to the present day. We show how the Finnish professoriate is highly selected both in terms of parental background and in terms of gender. Individuals of different backgrounds differ greatly in the likelihood of completing different educational and academic transitions, …
Interpreting wind damage risk-how multifunctional forest management impacts standing timber at risk of wind felling
2022
AbstractLandscape multifunctionality, a widely accepted challenge for boreal forests, aims to simultaneously provide timber, non-timber ecosystem services, and shelter for biodiversity. However, multifunctionality requires the use of novel forest management regimes optimally combined over the landscape, and an increased share of sets asides. It remains unclear how this combination will shape stand vulnerability to wind disturbances and exposed timber volume. We combined forest growth simulations and multi-objective optimization to create alternative landscape level forest management scenarios. Management choices were restricted to 1) rotation forestry, 2) continuous cover forestry, and 3) a…
Sisubiotus hakaiensis sp. nov. (Tardigrada, Macrobiotidae), a new tardigrade species from Calvert Island (British Columbia, Canada)
2022
Tardigrades reports from British Columbia (Canada) trace back to 1908 and numerous species have been recorded from this region, despite the relatively few published sampling studies. We describe by integrative taxonomy (light microscopy morphology, morphometrics, and DNA sequencing) a new tardigrade species, Sisubiotus hakaiensis sp. nov. from the British Columbia central coast. The new species has been found in moss collected from a vertical rock outcrop near the Hakai Institute Calvert Island Field Station. Sisubiotus hakaiensis sp. nov. differs from all the other known species in the genus by the presence of a labyrinthine layer inside the egg process walls, whereas no consistent differe…
Mehr als Musik: Die sieben Dimensionen des Eurovision Song Contests
2008
"Der Eurovision Song Contest (ESC) ist der weltweit größte internationale Wettbewerb für populäre Musik und das erfolgreichste Fernsehunterhaltungsprogramm in Europa. Obwohl der ESC ursprünglich das Ziel verfolgte, die Entstehung neuer Lieder zu fördern, handelte es sich doch stets um ein von den Fernsehanstalten inszeniertes Medienereignis, das erst nachrangig musikökonomischen Zwecken dient. Für das Publikum ist der ESC auf Grund seiner Periodizität, seiner spezifischen Programmstruktur und nicht zuletzt des Zugehörigkeitsgefühls der Zuschauer, das auf Schemata nationaler und kultureller Identifikation beruht, zu einem hochgradig ritualisierten Medienereignis geworden. Seine Bedeutung geh…
Territorial capital and the economic crisis: The role of spatial effects
2013
Activity-geospatial approach forms methodological basis of the concept of geospatial self-organization of a society as new theoretical paradigm of societal geography (SG) with next main principles: a) Self-organization of society and its key subsystems (economical, social, political, spiritual) in specifically localised natural and societal qualities of geospace (Earth's surface space) forms the process of geospatial self-organization of a society and its results - geospatial interests, processes, systems, structures as societal-geospatial phenomena of different scale (global, regional, local, etc.). So societal processes acquire specific geospatial shapes that combine a geospatial (geograp…
Contraintes et libertés textuelles
2006
The article starts from a conception of language according to which the semiotic units that speakers use do not emanate from individual mental processes but from the socialization of representation instruments which, being individual elements initially, have later been involved in processes of communicative circulation. In the same way that, in each language, verbal uses are limited by a series of restrictions in the constitution of some phonic, lexical or morphosyntactic structures, there are also some other constraints that affect textual genres. This means that these are the product of the history of the uses of language and that they work at a praxeologic level. These ideas apply to the…
MTOR inhibitor-based combination therapies for pancreatic cancer
2018
Background: Although the mechanistic target of rapamycin (MTOR) kinase, included in the mTORC1 and mTORC2 signalling hubs, has been demonstrated to be active in a significant fraction of patients with pancreatic ductal adenocarcinoma (PDAC), the value of the kinase as a therapeutic target needs further clarification. Methods: We used Mtor floxed mice to analyse the function of the kinase in context of the pancreas at the genetic level. Using a dual-recombinase system, which is based on the flippase-FRT (Flp-FRT) and Cre-loxP recombination technologies, we generated a novel cellular model, allowing the genetic analysis of MTOR functions in tumour maintenance. Cross-species validation and pha…
Protein tyrosine nitration and thiol oxidation by peroxynitrite-strategies to prevent these oxidative modifications.
2013
The reaction product of nitric oxide and superoxide, peroxynitrite, is a potent biological oxidant. The most important oxidative protein modifications described for peroxynitrite are cysteine-thiol oxidation and tyrosine nitration. We have previously demonstrated that intrinsic heme-thiolate (P450)-dependent enzymatic catalysis increases the nitration of tyrosine 430 in prostacyclin synthase and results in loss of activity which contributes to endothelial dysfunction. We here report the sensitive peroxynitrite-dependent nitration of an over-expressed and partially purified human prostacyclin synthase (3.3 μM) with an EC50 value of 5 μM. Microsomal thiols in these preparations effectively co…
Progress in HAXPES performance combining full-field k-imaging with time-of-flight recording
2019
Journal of synchrotron radiation 26(6), 1996-2012 (2019). doi:10.1107/S1600577519012773