Search results for "dea"
showing 10 items of 4491 documents
Spadanie i falowanie : trauma i żałoba Nicka Cave'a
2021
This article seeks to decode the artistic strategies employed by Nick Cave on two of his recent albums, Skeleton Tree (2016) and Ghosteen (2019), to process the trauma related to the sudden death of his teenage son, Arthur, in July 2015. Understandably, the literary layer of both productions is marked by the author’s grief and attempts to overcome it. However, the lyrics on both albums are also an account of a recovery from a trauma. It is a process composed of four stages: the shock experienced by an individual; desperate attempts to return to the reality before the trauma, which for obvious reasons turns out to be impossible; developing a trauma narrative, i.e. retelling a traumatic event…
The synergistic effect exerted by the HDAC inhibitor SAHA and the sesquiterpene lactone parthenolide on triple negative breast canc er cells
2014
Triple-negative breast cancer (TNBC) is a subtype o f breast cancer, insensitive to endocrine therapy. Chemotherapy is the main form of treatment, but is accompanied by a high rate of recidivism. The sesquiterpene lactone Parthenolide (PN) exerts a cy totoxic effect on MDA-MB231 cells, a TNBC cell line (1), but was ineffective at low doses (2-5μM). This repr esents an obstacle for a therapeutic utilization of PN. We supposed, in line with other authors (2), that PN c auses a protective response, which at low doses pre vails on the cytotoxic effect. With the aim of inhibiting this protective effect we have shown that pre-trea tment of MDA-MB231 cells with SAHA (2-5μM), an histone deace tylat…
The Aqua-Planet Experiment (APE): CONTROL SST Simulation
2013
Climate simulations by 16 atmospheric general circulation models (AGCMs) are compared on an aqua-planet, a water-covered Earth with prescribed sea surface temperature varying only in latitude. The idealised configuration is designed to expose differences in the circulation simulated by different models. Basic features of the aqua-planet climate are characterised by comparison with Earth. The models display a wide range of behaviour. The balanced component of the tropospheric mean flow, and mid-latitude eddy covariances subject to budget constraints, vary relatively little among the models. In contrast, differences in damping in the dynamical core strongly influence transient eddy amplitudes…
"Pociąg staje się niby nieskończony..." : podróż pociągiem w poemacie "Dwanaście stacji" Tomasza Różyckiego
2015
Työkulttuurien jännitteitä koulutusyhteisöissä
2019
Tarkastelemme artikkelissa jännitteitä koulutusyhteisöjen työkulttuureissa. Lähestymme aihetta opettajankoulutuksen kehittämiseen orientoituneesta koulutusmallista valmistuneiden opettajien kokemusten avulla. Tutkimuksen empiirisenä aineistona on 13 puolistrukturoitua yksilöhaastattelua, jotka kerättiin koulutusmalliin osallistuneilta opettajilta. Teoriasidonnaisessa sisällönanalyysissa keskityttiin yhteisön työkulttuuriin etsien myös sen vaikeammin havaittavia elementtejä, Scheinin (2017) sanoin perusolettamuksia.
 Tarkastelemme, miten yhteisöllisen ja kriittistä ammatillisuutta tukevan koulutusmallin anti on koettu ja miten sen vaikutukset ovat näyttäytyneet työelämässä. Tutkimuksemm…
Sisäistyneet ristiriidat, tunnetyö ja tietotyöläissubjektiviteetin rakentuminen
2015
Yliopistotyö on esimerkki uuden työn muodoista, joissa työ kiinnittyy aiempaa vahvemmin yksilöön. Samalla vastuu työelämän vaatimuksiin yltämisestä siirtyy työntekijälle itselleen. Työyhteisön ristiriitatilanteissa organisaation ongelmat sisäistyvät työntekijän yksityisiksi ja tunne-elämän ongelmiksi.
Rural Population in Romania. Development and Tendencies (2000 – 2010)
2013
Abstract Demography is among the top factors which exert an undeniable influence upon the economic environment. Therefore, the populace - through its dynamics and characteristics - leaves an imprint upon the social and economic landscape, being a keen barometer and contributing to economic progress. The relationship demography-economy is extremely tight, since the populace is perceived as being a true representation of what characterizes our economy. Romania originated as a country with an agriculture-based economy – a fact which translated in its major rural population; nowadays, due to a sum of various developments, the rural populace is undergoing a decreasing trend. The situation is all…
Social Media as Platform for Stimulating Urban Changes
2016
Images have always been an important part of city planning – current images of place, images with planned improvements, maps and sketches. Some time ago all that was a private property of stakeholders like planner and client. But nowadays this confidentiality rather much has vanished – no copyrights or competition is noteworthy. Plans do not have their privacy anymore. They are exposed even before they got implemented. This article will display why city planners share the images of their ideas, of their dreams in public (mostly in blogs and social networks) – why it is important for them and what kind of feedback they are waiting for. This article is based on case study where 12 respondents…
Rahan ja vallan sivut : talousjournalismin puhujat ja diskurssit Helsingin Sanomissa, Keskisuomalaisessa ja Etelä-Saimaassa
2014
Hyvälle talousjournalismille on tarvetta, sillä rahan liikkeet vaikuttavat ihmiskohtaloihin Pihtiputaalta Ateenaan. Millaista suomalainen talousjournalismi on, ja kenen ehdoilla sitä tehdään? Tämän tutkimuksen tarkoitus on selvittää, ketkä suomalaisessa talousjournalismissa pääsevät ääneen ja millaisissa rooleissa. Millaisia puhetapoja eli diskursseja puhujista käytetään? Analysoin työssäni Helsingin Sanomien, Keskisuomalaisen ja Etelä-Saimaan taloussivujen pää- ja kakkosjuttuja lokakuun 2010 ajalta. Työn teoreettisena viitekehyksenä kulkee kansalaisjournalistinen kritiikki. Se pyrkii journalismin lähdekäytäntöjen painopisteen vaihtamiseen. Taustalla on ajatus siitä, että journalismi lähinn…
Could PD-1/PDL1 immune checkpoints be linked to HLA signature?
2019
The outstanding clinical expansion of monoclonal antibodies (mAbs) to programmed cell death receptor-1 (PD-1) (nivolumab and pembrolizumab) and PD-1 ligand-1 (PDL-1) (atezolizumab, avelumab and durvalumab) has received an increasing level of interest regarding immunotherapy and multidrug combinations, for the treatment of a number of common human malignancies. Some patients treated with these agents receive remarkable benefits in term of quality of life, progression-free (PFS) and overall survival (OS). However, a significant percentage of these patients experience immune-related adverse events (irAEs), while others present with an ultra-rapid disease progression, defined as hyperprogressio…