Search results for "death"

Bortezomib Induces Anti–Multiple Myeloma Immune Response Mediated by cGAS/STING Pathway Activation

2021

Abstract The proteasome inhibitor bortezomib induces apoptosis in multiple myeloma cells and has transformed patient outcome. Using in vitro as well as in vivo immunodeficient and immunocompetent murine multiple myeloma models, we here show that bortezomib also triggers immunogenic cell death (ICD), characterized by exposure of calreticulin on dying multiple myeloma cells, phagocytosis of tumor cells by dendritic cells, and induction of multiple myeloma–specific immunity. We identify a bortezomib-triggered specific ICD gene signature associated with better outcome in two independent cohorts of patients with multiple myeloma. Importantly, bortezomib stimulates multiple myeloma cell immunogen…

The container of my soul was severed from my shell : Metaphors of Death in Contemporary Finnish Metal Lyrics

2009

 Raskaasta rockista ja metallista on tullut tänä päivänä Suomessa ainoana maana maailmassa valtavirtamusiikkia. Metallimusiikin saama suosio on tapahtunut niin nopeasti, että akateeminen maailma on vasta hiljattain havahtunut tutkimaan itse musiikkia ja ilmiötä, ja niissäkin harvoissa tapauksissa tutkimus on yleensä keskittynyt musiikin ääripäiden viittauksista ja mahdollisista yhteyksistä satanismiin tai väkivaltaiseen käytökseen. Englanninkielistä ns. ei-saatanallista metallimusiikkia on tutkittu Suomessa erittäin vähän ja tutkimuksen tarkoituksena olikin omalta osaltaan olla täyttämässä tätä tyhjiötä. Koska suurin yhteinen tekijä metallimusiikin sanoituksissa on kuolema, päädyttiin tässä…

The Deathbed Repentance in Tolstoy's "The Death of Ivan Ilych" and Conrad's "Heart of Darkness"

2022

L’autoesposizione a pericolo fra colpa in ambiti illeciti e autoresponsabilità: il caso delle morti da assunzione di stupefacenti

2020

La rilevanza dell'autoresponsabilità della vittima viene considerato in relazione al caso della morte del consumatore di droghe. Si tratta di un una problematica ampiamente esaminata nella giurisprudenza tedesca e in quella italiana, con differenti esiti sulle norme applicabili nei due sitemi penali e ulteriori conseguenze dogmatiche sulla teoria generale della responsabilità penale colposa. The relevance of the victim's self-responsibility is considered in relation to the case of the death of the drug user. This issue has been extensively examined in German and Italian jurisprudence, with different outcomes on the applicable rules in the two criminal systems and further dogmatic consequenc…

Śmierć, nieobecność i samotność - motyw traumatyzującej utraty matki w zbiorze opowiadań Lejli Kalamujić "Zovite me Esteban"

2019

Lejla Kalamujić (bom 1980) is a Bosnian writer from Sarajevo and the author of two collections of stories: Anatomy of a Smile (2009) and Call me Esteban (2015). The paper presents the autobiographical stories collected in the second book, in which the most important theme is death, especially the premature death of a mother. The aim of the article is to show the motive of the loss of a mother. The writer uses first-person narration and the protagonist is a woman named Lejla, a type of alter ego for her. The stories are written from different points of view and from different time perspectives. The intertextual themes in the book are the most interesting ones and have real artistic value (th…

Posttraumatic Propofol Neurotoxicity Is Mediated via the Pro–Brain-Derived Neurotrophic Factor-p75 Neurotrophin Receptor Pathway in Adult Mice*

2016

Objectives:The gamma-aminobutyric acid modulator propofol induces neuronal cell death in healthy immature brains by unbalancing neurotrophin homeostasis via p75 neurotrophin receptor signaling. In adulthood, p75 neurotrophin receptor becomes down-regulated and propofol loses its neurotoxic effect. H

IAP proteins as targets for drug development in oncology.

2013

The inhibitors of apoptosis (IAPs) constitute a family of proteins involved in the regulation of various cellular processes, including cell death, immune and inflammatory responses, cell proliferation, cell differentiation, and cell motility. There is accumulating evidence supporting IAP-targeting in tumors: IAPs regulate various cellular processes that contribute to tumor development, such as cell death, cell proliferation, and cell migration; their expression is increased in a number of human tumor samples, and IAP overexpression has been correlated with tumor growth, and poor prognosis or low response to treatment; and IAP expression can be rapidly induced in response to chemotherapy or …

Mechanisms of cell death in canine parvovirus-infected cells provide intuitive insights to developing nanotools for medicine

2010

Jonna Nykky, Jenni E Tuusa, Sanna Kirjavainen, Matti Vuento, Leona GilbertNanoscience Center and Department of Biological and Environmental Science, University of Jyväskylä, FinlandAbstract: Viruses have great potential as nanotools in medicine for gene transfer, targeted gene delivery, and oncolytic cancer virotherapy. Here we have studied cell death mechanisms of canine parvovirus (CPV) to increase the knowledge on the CPV life cycle in order to facilitate the development of better parvovirus vectors. Morphological studies of CPV-infected Norden laboratory feline kidney (NLFK) cells and canine fibroma cells (A72) displayed characteristic apoptotic events. Apoptosis was f…

The Major Heat Shock Proteins, Hsp70 and Hsp90, in 2-Methoxyestradiol-Mediated Osteosarcoma Cell Death Model

2020

2-Methoxyestradiol is one of the natural 17&beta

Apollon gene silencing induces apoptosis in breast cancer cells via p53 stabilisation and caspase-3 activation

2009

We analysed the effects of small interfering RNA (siRNA)-mediated silencing of Apollon, a member of the inhibitors of apoptosis protein family, on the proliferative potential and ability of human breast cancer cell lines to undergo apoptosis. In wild-type p53 ZR75.1 cells, Apollon knockdown resulted in a marked, time-dependent decline of cell growth and an increased rate of apoptosis, which was associated with p53 stabilisation and activation of the mitochondrial-dependent apoptotic pathway. Pre-incubation of cells with a p53-specific siRNA resulted in a partial rescue of cell growth inhibition, as well as in a marked reduction of the apoptotic response, indicating p53 as a major player in …