Search results for "deformable"
showing 10 items of 11 documents
A novel ultradeformable liposomes of Naringin for anti-inflammatory therapy
2018
[EN] Ultradeformable liposomes were formulated using naringin (NA), a flavanone glycoside, at different concentrations (3, 6 and 9 mg/mL). Nanovesicles were small size (similar to 100 nm), regardless of the NA concentration used, and monodisperse (PI<0.30). All formulations showed a high entrapment efficiency (similar to 88%) and a highly negative zeta potential (around -30 mV). The selected formulations were highly biocompatible as confirmed by in vitro studies using 3T3 fibroblasts. In vitro assay showed that the amounts (%) of NA accumulated in the epidermis (similar to 10%) could explain the anti-inflammatory properties of ultradeformable liposomes. In vivo studies confirmed the higher …
Three-dimensional multiple-particle tracking with nanometric precision over tunable axial ranges
2017
The precise localization of nanometric objects in three dimensions is essential to identify functional diffusion mechanisms in complex systems at the cellular or molecular level. However, most optical methods can achieve high temporal resolution and high localization precision only in two dimensions or over a limited axial (z) range. Here we develop a novel wide-field detection system based on an electrically tunable lens that can track multiple individual nanoscale emitters in three dimensions over a tunable axial range with nanometric localization precision. The optical principle of the technique is based on the simultaneous acquisition of two images with an extended depth of field while …
Validación del registro deformable de imágenes en radioterapia adaptativa
2017
En los últimos años, una de las áreas de mayor interés en la radioterapia ha sido la radioterapia adaptativa (ART), siendo la forma más versátil y eficiente de realizarla utilizar el registro de imágenes deformable (DIR). Este se basa en crear un campo de deformación vectorial entre dos imágenes, que permite relacionar los vóxels de una imagen con la otra. Una de las grandes dificultades para implementar la ART en los centros hospitalarios es la dificultad para validar si el algoritmo de DIR relaciona correctamente las dos imágenes que queremos registrar deformablemente. En esta tesis se pretende validar el algoritmo hibrido del sistema de planificación computarizada (TPS) RayStation (v.4.0…
The effect of longitudinal chromatic aberration on the lag of accommodation and depth of field.
2016
Purpose Longitudinal chromatic aberration is present in all states of accommodation and may play a role in the accommodation response and the emmetropisation process. We study the change of the depth of field (DOFi) with the state of accommodation, taking into account the longitudinal chromatic aberration. Methods Subjective DOFi was defined as the range of defocus beyond which the blur of the target (one line of optotypes of 0.1 logMAR shown on a black-and-white microdisplay, seen through different colour filters) was perceived as objectionable. The subject's eye was paralysed and different, previously-measured accommodative states (corresponding to the accommodative demands of 0D, 2D and …
Accommodation Responds to Optical Vergence and Not Defocus Blur Alone.
2017
Purpose To determine whether changes in wavefront spherical curvature (optical vergence) are a directional cue for accommodation. Methods Nine subjects participated in this experiment. The accommodation response to a monochromatic target was measured continuously with a custom-made adaptive optics system while astigmatism and higher-order aberrations were corrected in real time. There were two experimental open-loop conditions: vergence-driven condition, where the deformable mirror provided sinusoidal changes in defocus at the retina between -1 and +1 diopters (D) at 0.2 Hz; and blur-driven condition, in which the level of defocus at the retina was always 0 D, but a sinusoidal defocus blur …
Position based constraint enforcement in game physics
2016
La simulación de sistemas mecánicos para videojuegos y otras aplicaciones interactivas impone restricciones importantes en cuanto a estabilidad, flexibilidad en las escenas y complejidad computacional. En los últimos años han aparecido varias estrategias para la resolución de sistemas mecánicos con restricciones. Algunas de las más populares en el desarrollo de videojuegos usan solamente la posición de las partículas y un algoritmo de proyección sobre la variedad definida por las restricciones, evitando la manipulación de la primera derivada del sistema (las velocidades). De esta forma se consigue una gran estabilidad numérica. El principal defecto de estos métodos es su dependencia en pará…
Numerical model for the shear rheology of two-dimensional wet foams with deformable bubbles
2014
Shearing of two-dimensional wet foam is simulated using an introduced numerical model, and results are compared to those of experiments. This model features realistically deformable bubbles, which distinguishes it from previously used models for wet foam. The internal bubble dynamics and their contact interactions are also separated in the model, making it possible to investigate the effects of the related microscale properties of the model on the macroscale phenomena. Validity of model assumptions was proved here by agreement between the simulated and measured Herschel-Bulkley rheology, and shear-induced relaxation times. This model also suggests a relationship between the shear stress and…
Effects of nonlinearity and substrate’s deformability on modulation instability in NKG equation
2017
International audience; This article investigates combined effects of nonlinearities and substrate's deformability on modulational instability. For that, we consider a lattice model based on the nonlinear Klein-Gordon equation with an on-site potential of deformable shape. Such a consideration enables to broaden the description of energy-localization mechanisms in various physical systems. We consider the strong-coupling limit and employ semi-discrete approximation to show that nonlinear wave modulations can be described by an extended nonlinear Schrodinger equation containing a fourth-order dispersion component. The stability of modulation of carrier waves is scrutinized and the following …
Temporal multiplexing with adaptive optics for simultaneous vision.
2016
We present and test a methodology for generating simultaneous vision with a deformable mirror that changed shape at 50 Hz between two vergences: 0 D (far vision) and −2.5 D (near vision). Different bifocal designs, including toric and combinations of spherical aberration, were simulated and assessed objectively. We found that typical corneal aberrations of a 60-year-old subject changes the shape of objective through-focus curves of a perfect bifocal lens. This methodology can be used to investigate subjective visual performance for different multifocal contact or intraocular lens designs.
Investigation into water retention behaviour of deformable soils
2013
The paper presents an experimental and modelling approach for the soil-water retention behaviour of two deformable soils. The objective is to investigate the physical mechanisms that govern the soil-water retention properties and to propose a constitutive framework for the soil-water retention curve accounting for the initial state of compaction and deformability of soils. A granular soil and a clayey soil were subjected to drying over a wide range of suctions so that the residual state of saturation could be attained. Different initial densities were tested for each material. The soil-water retention curves (SWRCs) obtained are synthesized and compared in terms of water content, void rati…