Search results for "degeneracy"
showing 10 items of 46 documents
Molecular signatures of silencing suppression degeneracy from a complex RNA virus
2021
As genomic architectures become more complex, they begin to accumulate degenerate and redundant elements. However, analyses of the molecular mechanisms underlying these genetic architecture features remain scarce, especially in compact but sufficiently complex genomes. In the present study, we followed a proteomic approach together with a computational network analysis to reveal molecular signatures of protein function degeneracy from a plant virus (as virus-host protein-protein interactions). We employed affinity purification coupled to mass spectrometry to detect several host factors interacting with two proteins of Citrus tristeza virus (p20 and p25) that are known to function as RNA sil…
Nature versus design: synthetic biology or how to build a biological non-machine.
2015
The engineering ideal of synthetic biology presupposes that organisms are composed of standard, interchangeable parts with a predictive behaviour. In one word, organisms are literally recognized as machines. Yet living objects are the result of evolutionary processes without any purposiveness, not of a design by external agents. Biological components show massive overlapping and functional degeneracy, standard-free complexity, intrinsic variation and context dependent performances. However, although organisms are not full-fledged machines, synthetic biologists may still be eager for machine-like behaviours from artificially modified biosystems.
(Bounded) Traveling combustion fronts with degenerate kinetics
2022
Abstract We consider the propagation of a flame front in a solid periodic medium. It is governed by an equation of Hamilton–Jacobi type, whose front’s velocity depends on the temperature via a nonlinear degenerate kinetic rate. The temperature solves a free boundary problem subject to boundary conditions depending on the front’s velocity itself. We show the existence of nonplanar traveling wave solutions which are bounded and global. Previous results by the same authors (cf. Alibaud and Namah, 2017) were obtained for essentially positively lower bounded kinetics or eventually which have some very weak degeneracy. Here we consider very general degenerate kinetics, including for the first tim…
Cosmological lepton asymmetry with a nonzero mixing angle \theta13
2012
While the baryon asymmetry of the Universe is nowadays well measured by cosmological observations, the bounds on the lepton asymmetry in the form of neutrinos are still significantly weaker. We place limits on the relic neutrino asymmetries using some of the latest cosmological data, taking into account the effect of flavor oscillations. We present our results for two different values of the neutrino mixing angle \theta_{13}, and show that for large \theta_{13} the limits on the total neutrino asymmetry become more stringent, diluting even large initial flavor asymmetries. In particular, we find that the present bounds are still dominated by the limits coming from Big Bang Nucleosynthesis, …
A large-energy-gap oxide topological insulator based on the superconductor BaBiO3
2013
Mixed-valent perovskite oxides based on BaBiO3 (BBO) are, like cuperates, well-known high-Tc superconductors. Recent ab inito calculations have assigned the high-Tc superconductivity to a correlation-enhanced electron--phonon coupling mechanism, stimulating the prediction and synthesis of new superconductor candidates among mixed-valent thallium perovskites. Existing superconductivity has meant that research has mainly focused on hole-doped compounds, leaving electron-doped compounds relatively unexplored. Here we demonstrate through ab inito calculations that BBO emerges as a topological insulator (TI) in the electron-doped region, where the spin-orbit coupling (SOC) effect is significant.…
The Coble Quadric
2023
Given a smooth genus three curve $C$, the moduli space of rank two stable vector bundles on C with trivial determinant embeds in $\mathbb{P}^8$ as a hypersurface whose singular locus is the Kummer threefold of $C$; this hypersurface is the Coble quartic. Gruson, Sam and Weyman realized that this quartic could be constructed from a general skew-symmetric fourform in eight variables. Using the lines contained in the quartic, we prove that a similar construction allows to recover SU$_C(2, L)$, the moduli space of rank two stable vector bundles on C with fixed determinant of odd degree L, as a subvariety of $G(2, 8)$. In fact, each point $p \in C$ defines a natural embedding of SU$_C(2, \mathca…
Population Monte Carlo Schemes with Reduced Path Degeneracy
2017
Population Monte Carlo (PMC) algorithms are versatile adaptive tools for approximating moments of complicated distributions. A common problem of PMC algorithms is the so-called path degeneracy; the diversity in the adaptation is endangered due to the resampling step. In this paper we focus on novel population Monte Carlo schemes that present enhanced diversity, compared to the standard approach, while keeping the same implementation structure (sample generation, weighting and resampling). The new schemes combine different weighting and resampling strategies to reduce the path degeneracy and achieve a higher performance at the cost of additional low computational complexity cost. Computer si…
Concurrent Changes of Brain Functional Connectivity and Motor Variability When Adapting to Task Constraints
2018
In behavioral neuroscience, the adaptability of humans facing different constraints has been addressed on one side at the brain level, where a variety of functional networks dynamically support the same performance, and on the other side at the behavioral level, where fractal properties in sensorimotor variables have been considered as a hallmark of adaptability. To bridge the gap between the two levels of observation, we have jointly investigated the changes of network connectivity in the sensorimotor cortex assessed by modularity analysis and the properties of motor variability assessed by multifractal analysis during a prolonged tapping task. Four groups of participants had to produce th…
Can we measure the neutrino mass hierarchy in the sky?
2010
Cosmological probes are steadily reducing the total neutrino mass window, resulting in constraints on the neutrino-mass degeneracy as the most significant outcome. In this work we explore the discovery potential of cosmological probes to constrain the neutrino hierarchy, and point out some subtleties that could yield spurious claims of detection. This has an important implication for next generation of double beta decay experiments, that will be able to achieve a positive signal in the case of degenerate or inverted hierarchy of Majorana neutrinos. We find that cosmological experiments that nearly cover the whole sky could in principle distinguish the neutrino hierarchy by yielding 'substan…
Quantum field theory of dilute homogeneous Bose-Fermi mixtures at zero temperature: General formalism and beyond mean-field corrections
2002
We consider a dilute homogeneous mixture of bosons and spin-polarized fermions at zero temperature. We first construct the formal scheme for carrying out systematic perturbation theory in terms of single particle Green's functions. We introduce a new relevant object, the renormalized boson-fermion T-matrix which we determine to second order in the boson-fermion s-wave scattering length. We also discuss how to incorporate the usual boson-boson T-matrix in mean-field approximation to obtain the total ground state properties of the system. The next order term beyond mean-field stems from the boson-fermion interaction and is proportional to $a_{\scriptsize BF}k_{\scriptsize F}$. The total groun…