Search results for "delay"
showing 10 items of 814 documents
Types of Moving Averages
2017
This chapter presents a detailed review of all ordinary types of moving averages, as well as some exotic types of moving averages. These exotic moving averages include moving averages of moving averages and mixed moving averages with less average lag time. For the majority of moving averages, this chapter computes the closed-form solutions for the average lag time and smoothness. This chapter also demonstrates that the average lag time of a moving average can easily be manipulated; therefore the notion of the average lag time has very little to do with the delay time in the identification of turning points in a price trend.
In Situ Perfusion Model in Rat Colon for Drug Absorption Studies: Comparison with Small Intestine and Caco-2 Cell Model.
2015
Our aim is to develop and to validate the in situ closed loop perfusion method in rat colon and to compare with small intestine and Caco-2 cell models. Correlations with human oral fraction absorbed (Fa) and human colon fraction absorbed (Fa_colon) were developed to check the applicability of the rat colon model for controlled release (CR) drug screening. Sixteen model drugs were selected and their permeabilities assessed in rat small intestine and colon, and in Caco-2 monolayers. Correlations between colon/intestine/Caco-2 permeabilities versus human Fa and human Fa_colon have been explored to check model predictability and to apply a BCS approach in order to propose a cut off value for CR…
In situ formation of steroidal supramolecular gels designed for drug release
2013
In this work, a steroidal gelator containing an imine bond was synthesized, and its gelation behavior as well as a sensitivity of its gels towards acids was investigated. It was shown that the gels were acid-responsive, and that the gelator molecules could be prepared either by a conventional synthesis or directly in situ during the gel forming process. The gels prepared by both methods were studied and it was found that they had very similar macroand microscopic properties. Furthermore, the possibility to use the gels as carriers for aromatic drugs such as 5-chloro-8-hydroxyquinoline, pyrazinecarboxamide, and antipyrine was investigated and the prepared two-component gels were studied with…
Defining level A IVIVC dissolution specifications based on individual in vitro dissolution profiles of a controlled release formulation.
2018
Regulatory guidelines recommend that, when a level A IVIVC is established, dissolution specification should be established using averaged data and the maximum difference between AUC and Cmax between the reference and test formulations cannot be greater than 20%. However, averaging data assumes a loss of information and may reflect a bias in the results. The objective of the current work is to present a new approach to establish dissolution specifications using a new methodology (individual approach) instead of average data (classical approach). Different scenarios were established based on the relationship between in vitro-in vivo dissolution rate coefficient using a level A IVIVC of a cont…
Reproductive medicine and inheritance of infertility by offspring: the role of fetal programming.
2011
Objective To summarize the molecular processes involved in fetal programming, to describe how assisted reproduction technologies (ART) may affect the epigenetic pattern of the embryo, and to highlight the current knowledge of the role of perinatal events in the subsequent development of reproductive pathology affecting infertile patients. Design A literature review of fetal programming of adulthood gynecologic diseases and ART. A Medline search was performed with the following keywords: (fetal programming OR epigenetics OR methylation OR acetylation) AND (IVF OR ART) AND (gynecology). Articles up to October 2010 were selected. Articles and recent reviews were classified by human and animals…
Delay-dependent exponential stabilization of positive 2D switched state-delayed systems in the Roesser model
2014
This paper deals with the controller synthesis for a class of positive two-dimensional (2D) switched delay systems described by the Roesser model. This kind of systems has the property that the states take nonnegative values whenever the initial boundaries are nonnegative, some delay-dependent sufficient conditions for the exponential stability of positive 2D switched systems with state delays are given. Furthermore, the design of positive state feedback controller under which the resulting closed-loop system meets the requirements of positivity and exponential stability is presented in terms of linear matrix inequalities (LMIs). An example is included to illustrate the effectiveness of the…
Robust stability and stabilization of uncertain T-S fuzzy systems with time-varying delay: An input-output approach
2013
An input-output approach to the stability and stabilization of uncertain Takagi-Sugeno (T-S) fuzzy systems with time-varying delay is proposed in this paper. The time-varying parameter uncertainties are assumed to be norm-bounded, and the delay is intervally time varying. A novel method is employed to approximate the time-varying delay, based on which the considered system is transformed into a feedback interconnection form. The new formulation of the system is comprised of a forward subsystem with constant time delay and a feedback subsystem embedding the uncertainties. By applying the scaled small-gain theorem to the converted system, less conservative stability and stabilization criteria…
Input-Output Finite-Time Stability of Discrete-Time Impulsive Switched Linear Systems with State Delays
2013
Published version of an article in the journal: Circuits, Systems, and Signal Processing. Also available from the publisher at: http://dx.doi.org/10.1007/s00034-013-9610-7 This paper is concerned with the problem of input-output finite-time stability (IO-FTS) for discrete impulsive switched systems with state delays. Sufficient conditions are presented for the existence of IO-FTS for such systems under the cases of certain switching, arbitrary switching, and uncertain switching. All the obtained results are formulated in a set of linear matrix inequalities (LMIs). Two numerical examples are given to illustrate the effectiveness of the proposed results.
Inhibition of Delayed-Type Hypersensitivity by Cucurbitacin R through the Curbing of Lymphocyte Proliferation and Cytokine Expression by Means of Nuc…
2009
Cucurbitacin R is known to exhibit an anti-inflammatory effect in different experimental models of inflammation. In this article, we outline the effect of cucurbitacin R on T lymphocyte proliferation, cytokine production, and nuclear factor activation, as well as its influence on various experimental models of delayed-type hypersensitivity (DTH) in mice. Cucurbitacin R reduced the proliferation of phytohemagglutinin A-stimulated human T lymphocytes (IC(50), 18 microM), modifying the cell cycle, as well as the production of cytokines [interleukin (IL)-2, IL-4, IL-10, and especially interferon-gamma] and the induction of the principal cyclins implicated in the cell cycle (A(1), B(1), D(2), an…