Search results for "delēcijas"

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Subtelomēru rajona hromatīna struktūras izmaiņu noteikšana ar qPCR

2015

Cilvēka subtelomēri ir izteikti polimorfiski un ir ar vislielāko gēnu blīvumu visā genomā. Subtelomēru sekvences pārmaiņas ir saistītas ar mentālo atpalicību, ļaundabīgām hematoloģiskajām slimībām, atkārtotiem spontānajiem abortiem un citām slimībām. Tādēļ subtelomēru reģiona pārmaiņu konstatēšana ir svarīga klīniskās izpētes sastāvdaļa. Subtelomēru pētniecībā galvenokārt tiek pielietotas divas metodes: FISH un SAT. Šajā darbā tika aprakstīta qPCR metode subtelomēru analīzei, kas, teorētiski ir lētāka, ātrāka un precīzāka alternatīva FISH un SAT metodēm. Darbā apraksta qPCR metodes pielietošanu, Y hromosomas p pleca subtelomēru reģiona pārmaiņu pētīšanai, 34 DNS paraugiem, kas iegūti no nea…

qPCRSubtelomēriFISHduplikācijasdelēcijasBioloģija

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PEPhysical Sciences and Engineering
- PE2Fundamental Constituents of Matter
  - PE2_1Theory of fundamental interactions
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LSLife Sciences
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- LS2Integrative Biology: from Genes and Genomes to Systems
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SHSocial Sciences and Humanities
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