Search results for "depression"
showing 10 items of 1778 documents
Temperamentos afectivos y edad de inicio en pacientes bipolares tipo II
2016
Actualmente es imperante contar con indicadores que posibiliten realizar una detección temprana y correcta del trastorno bipolar en general, y del tipo II, en particular. Los temperamentos afectivos constituyen estilos de reactividad emocional temporalmente estables a lo largo del ciclo vital, con una importante base biológica. Dada la escasez de investigaciones al respecto, se exploraron posibles asociaciones entre la edad de inicio de 32 pacientes eutímicos con diagnóstico de trastorno bipolar tipo II y los temperamentos afectivos ciclotímico, depresivo, irritable, ansioso e hipertímico. Los participantes presentaron una edad media de 51,5 años (rango intercuartil 8) y el 65,6% de la mues…
Medicinal Plants in the Treatment of Depression. II: Evidence from Clinical Trials
2021
AbstractDepression is a syndrome characterized by deep sadness and the inhibition of psychic functions, sometimes accompanied by neurovegetative disorders, with symptoms of anxiety almost always present. The disease produces alterations in a variety of neural networks and neurotransmission systems, along with a dysfunction of the hypothalamic-pituitary-adrenal axis, which leads to concomitant alterations in the immunological response. Generally, there is a parallel increase in proinflammatory mediators as well as oxidative and nitrosative damage caused by a reduction of antioxidant defenses. In a previous review, we compiled and examined studies of medicinal plants that had been evaluated i…
Role of physical activity in ameliorating neuropsychiatric symptoms in Alzheimer disease: A narrative review
2019
Objective: Neuropsychiatric symptoms (NPs) affect almost all patients with Alzheimer disease (AD). Because of the complications associated with the pharmacological treatment, nonpharmacological treatment (such as physical activity) can be considered as an additional complementary treatment option for NPs. The aim of this review is to evaluate the impact of physical activity on NPs in patients with AD. Methods: We searched Pubmed and Google Scholar for potential eligible articles until March 1, 2018. Results: Although there are contradictory results showing the impact of physical exercise on NPs, most of them reported that it had a significant effect on depression and sleep disturbances in p…
Cultural adaptation of the Smiling is Fun program for the treatment of depression in the Ecuadorian public health care system: A study protocol for a…
2021
Background Depression is one of the world's major health problems. Due to its high prevalence, it constitutes the first cause of disability among the Americas, where only a very low percentage of the population receives the adequate evidence-based psychological treatment. Internet-Based Interventions (IBIs) are a great alternative to reduce the treatment gap for mental disorders. Although there are several studies in low-and middle-income countries proving IBIs' feasibility and acceptability, there is still little evidence of the effectiveness in diverse social and cultural contexts such as Latin America. Methods Two studies will be described: Study 1 is focused on the cultural adaptation o…
Immunological and psychological responses to psychosocial stress in caregivers of autistic offspring
2011
IntroductionCaregivers of relatives with chronic diseases has shown lower rest levels of immunoglobulin A than non-caregivers (Gallagher et al., 2008). In response to mental stress, IgA levels used to be increased in healthy population (Okamura et al. 2010). Scarce studies have been focused on immunological effects of caregiving in response to stress, and the results are controversial. To our knowledge, there are no studies stressing this field in chronically stressed populations such as caregivers of autistic offspring.Objectives and aimsEvaluate whether caregivers present different psychosocial and immunological responses to acute stress than non-caregivers, as well as what is the role of…
The role of depression and impulsivity in the psychopathology of bulimia nervosa.
2013
Introduction: The study aimed to analyze the role of depression and impulsivity in the psychopathology of bulimia nervosa (BN). Materials and methods: Seventy female patients with DSM-IV BN, purging subtype, were assessed for eating-related symptoms, body dissatisfaction, affective symptoms, impulsivity, and personality traits. Factor analysis and structural equation modeling methods were used for statistical analysis. Results: BN appeared as a condition which incorporated 5 general dimensions: a) binge eating and compensatory behaviours; b) restrictive eating; c) body dissatisfaction; d) dissocial personality traits; and e) a cluster of features which was called "emotional instability" The…
Withanone Ameliorates Stress Symptoms in Caenorhabditis Elegans by Acting through Serotonin Receptors
2021
ABSTRACT Introduction Depression is responsible for 800 000 deaths worldwide, a number that will rise significantly due to the COVID-19 pandemic. Affordable novel drugs with less severe side effects are urgently required. We investigated the effect of withanone (WN) from Withania somnifera on the serotonin system of wild-type and knockout Caenorhabditis elegans strains using in silico, in vitro, and in vivo methods. Methods WN or fluoxetine (as positive control drug) was administered to wild-type (N2) and knockout C. elegans strains (AQ866, DA1814, DA2100, DA2109, and MT9772) to determine their effect on oxidative stress (Trolox, H2DCFDA, and juglone assays) on osmotic stress and heat stres…
Mother and infant affective involvement states and maternal depression
1997
This study shows two different dimensional types of maternal depression, one dull and slow, the other stressed and irritable. When the quality of the infant attachment to mother is assessed, it is noted that the dimensional aspect of the maternal depression can be of some importance in the quality of the attachment. In fact, children are more inclined to develop an insecure–ambivalent attachment to their stressed depressed mothers, while children of slow depressed mothers are more insecure–avoiding. Thus, the dimensions of maternal depression can be an indicator of the type of insecure attachment of the infant at one year of age. We have also found that insecure children of depressed mother…
Efficacy of a functional therapy program for depression and c-reactive protein: A pilot study
2021
Objective: Affecting more than 264 million people, depression is a systemic and multifactorial disorder that represents one of the leading causes of illness and disability worldwide. Several studies showed an inflammatory response in depressed patients, including the involvement of both chronic low-grade inflammatory response and activation of cell-mediated immunity. The present study aimed to verify the efficacy of a structured functional therapy program for patients with depressed mood, and to determine whether this program can significantly reduce levels of C-reactive protein. Method: 28 outpatients with depressed mood received 20 individual sessions of Functional therapy. Data about soc…
Papaverine enhances the negative inotropic effect of acetylcholine in rat auricles
1978
The negative inotropic effect of acetylcholine in rat left auricles is enhanced in the presence of the phosphodiesterase inhibitor papaverine. This result favours the idea of a cyclic GMP-mediated action of acetylcholine in the heart.