Search results for "derived"

showing 10 items of 452 documents

SPARC is a new myeloid-derived suppressor cell marker licensing suppressive activities

2019

Myeloid-derived suppressor cells (MDSC) are well-known key negative regulators of the immune response during tumor growth, however scattered is the knowledge of their capacity to influence and adapt to the different tumor microenvironments and of the markers that identify those capacities. Here we show that the secreted protein acidic and rich in cysteine (SPARC) identifies in both human and mouse MDSC with immune suppressive capacity and pro-tumoral activities including the induction of epithelial-to-mesenchymal transition (EMT) and angiogenesis. In mice the genetic deletion of SPARC reduced MDSC immune suppression and reverted EMT. Sparc−/− MDSC were less suppressive overall and the granu…

STAT3 Transcription Factorlcsh:Immunologic diseases. Allergy0301 basic medicineEpithelial-Mesenchymal TransitionAngiogenesisImmunologyneutrophil extracellular trapsNitric Oxide Synthase Type IIInflammationExtracellular TrapsMice03 medical and health sciences0302 clinical medicineImmune systemBreast cancermedicineMyeloid-derived suppressor cellAnimalsHumansImmunology and AllergyOsteonectinOriginal ResearchMice KnockoutMice Inbred BALB CTumor microenvironmentArginaseChemistryNeutrophilNF-kappa B p50 SubunitSPARCNeutrophil extracellular trapsmyeloid-derived suppressor cells030104 developmental biologyCancer researchMyeloid-derived Suppressor CellTumor necrosis factor alphaSignal transductionmedicine.symptomlcsh:RC581-607Neutrophil extracellular trapBiomarkers030215 immunology
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Cholesterol Starvation and Hypoxia Activate the FVII Gene via the SREBP1-GILZ Pathway in Ovarian Cancer Cells to Produce Procoagulant Microvesicles

2019

AbstractInteraction between the transcription factors, hypoxia-inducible factor (HIF1α and HIF2α) and Sp1, mediates hypoxia-driven expression of FVII gene encoding coagulation factor VII (fVII) in ovarian clear cell carcinoma (CCC) cells. This mechanism is synergistically enhanced in response to serum starvation, a condition possibly associated with tumor hypoxia. This transcriptional response potentially results in venous thromboembolism, a common complication in cancer patients by producing procoagulant extracellular vesicles (EVs). However, which deficient serum factors are responsible for this characteristic transcriptional mechanism is unknown. Here, we report that cholesterol deficien…

Serum0301 basic medicineLeucine zipper030204 cardiovascular system & hematologyMice03 medical and health sciences0302 clinical medicineCell-Derived MicroparticlesCell Line Tumorhemic and lymphatic diseasesAnimalsHumansHypoxiaTranscription factorOvarian NeoplasmsTumor hypoxiaCoagulantsChemistryHematologyFactor VIIChromatin Assembly and DisassemblyHypoxia-Inducible Factor 1 alpha SubunitXenograft Model Antitumor AssaysMicrovesiclesChromatinCell biologySterol regulatory element-binding proteinCholesterol030104 developmental biologyFemaleSignal transductionSterol Regulatory Element Binding Protein 1Chromatin immunoprecipitationSignal TransductionTranscription FactorsThrombosis and Haemostasis
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Gametic embryogenesis through isolated microspore culture in mandarin (Citrus reticulata Blanco), Mandarino Tardivo Di Ciaculli: effect of meta-Topol…

2016

Haploid technology, allowing the single-step development of complete homozygous genotypes from heterozygous plants through gametic embryogenesis, has already an enormous impact on breeding programs of many important crops. Microspore embryogenesis can be carried out through in vitro culture of anther or isolated microspore. Experiments have been carried out via isolated microspore culture in Citrus reticulata (Blanco), Mandarino Tardivo di Ciaculli, investigating the influence of two culture media, of two plant growth regulator types and of two temperature treatments applied before the culture or just after the culture. After ten months of culture, for all the media tested, different struct…

Settore AGR/03 - Arboricoltura Generale E Coltivazioni ArboreeHorticultureMicrosporebreeding haploid homozygosity microspore-derived embryosEmbryogenesisBotanylanguageGeneral Earth and Planetary SciencesBiologyMandarin Chineselanguage.human_languageGeneral Environmental Science
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Isolation and characterisation of tangerin-derived extracellular vesicles

2021

Settore BIO/13 - Biologia Applicataplant-derived extracellular vesicles.
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La Sicilia negli Orsi di Dino Buzzati e Lorenzo Mattotti

2022

Nella fiaba illustrata di Dino Buzzati La famosa invasione degli orsi in Sicilia (1945) e nella sua trasposizione filmica ad opera di Lorenzo Mattotti (2019) l’ambientazione siciliana è determinante. In entrambi i casi la Sicilia è un’isola con un grande vulcano – trasfigurata in un ambiente fantastico o riscritta secondo alcuni stereotipi – che i due autori utilizzano con accezioni diverse nella costituzione dell’ecosistema delle loro narrazioni. Soltanto attraverso una comparazione tra le due opere sarà possibile distinguere la rappresentazione delle due Sicilie che vengono raccontate con un intervallo di circa settanta anni. Se non si considera la storia degli Orsi soltanto una fiaba per…

Settore L-FIL-LET/14 - Critica Letteraria E Letterature ComparateSicily in Bears of Dino Buzzati and Lorenzo Mattotti · In Dino Buzzati’s illustrated fairy tale The Famous Invasion of the Bears in Sicily (1945) and its film adaptation by Lorenzo Mattotti (2019) the Sicilian setting is decisive. In both cases Sicily is an island with a large volcano – transfigured into a fantastic setting or rewritten according to certain stereotypes – that the two authors use with different meanings within the ecosystem of their narratives. Only through a comparison between the two works will it be possible to distinguish the representation of the two Sicilies which are narrated within an interval of about seventy years. If one does not consider the story of the Bears merely a children’s fairy tale using simplistic stylistic devices but on the contrary sees it as an opportunity for the author to deal with serious and complex issues such as an ante litteram Ecocritical perspective or questions of inter-group conflicts derived from Subaltern or Migration Studies the images of the two Sicilies can provide altogether new interpretations.
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INTRODUCING NON-ADHERENT PROGENITORS FROM ADIPOSE-DERIVED STEM CELLS (NAPADSCS): PROOF OF STEMNESS AND POSSIBLE FUTURE APPLICATIONS IN REGENERATIVE S…

2012

Introduction: Mesenchymal Stromal Cells (MSCs) can be isolated from adipose tissue and are currently used in vitro for experimental studies. MSCs are often mislabeled as Adipose-derived Stem Cells (ADSCs) despite presenting a more differentiated phenotype. The isolation and expansion of non-adherent progenitors from adipose-derived stem cells (napADSCs), has been achieved in our laboratory and is currently under investigation. In this study we investigate: a) the proof of stemness of such progenitors, and b) the feasibility of napADSCs adhesion over Integra® for cell colonization and for future differentiation and engineering of semi-synthetic tissues. Material and Methods: Adipose tissue (…

Settore MED/19 - Chirurgia PlasticaADIPOSE-DERIVED STEM CELLS
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The associated sheaf functor theorem in algebraic set theory

2008

We prove a version of the associated sheaf functor theorem in Algebraic Set Theory. The proof is established working within a Heyting pretopos equipped with a system of small maps satisfying the axioms originally introduced by Joyal and Moerdijk. This result improves oil the existing developments by avoiding the assumption of additional axioms for small maps and the use of collection sites.

Sheaf cohomologyFunctorDirect image functorLogicInvertible sheafIdeal sheafAlgebraMathematics::LogicDerived algebraic geometryMathematics::Category TheorySheafAlgebraic set theory presheaves sheavesInverse image functorMathematics
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LabVIEW modeling and simulation, of the digital filters

2015

In order to study digital filters using virtual instrumentation a simulation program specifically designed for this purpose has been developed. To implement this program means to use the following facilities: studying digital Butterworth filters, Cebyshev, Bessel and Median and change their parameters: bandwidth, order, rank and slope; possibility of changing the input parameters: amplitude, offset and frequency; overlay over the input signal, to one of the types of noise such as white noise, Gaussian white noise and Poisson noise; choosing a type of digital filters: low pass, high pass, band-pass and band stop; waveforms graphical representation of the input and output signals; graphical r…

Signal processingComputer scienceShot noiseElectronic engineeringPrototype filterWhite noiseNetwork synthesis filtersm-derived filterLinear filterAudio filter2015 13th International Conference on Engineering of Modern Electric Systems (EMES)
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New combinations for mantle cell lymphoma: concerted action needed.

2011

Sirolimusbusiness.industryLymphoma Mantle-Cellmedicine.diseaseArticleAntibodies Monoclonal Murine-DerivedOncologyAction (philosophy)Antineoplastic Combined Chemotherapy ProtocolsCancer researchMedicineHumansMantle cell lymphomabusinessRituximabThe Lancet. Oncology
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Increased frequencies of CD11b+CD33+CD14+HLA-DRlowmyeloid-derived suppressor cells are an early event in melanoma patients

2014

Myeloid-derived suppressor cells (MDSC) are a heterogeneous cell population characterized by immunosuppressive activity. Elevated levels of MDSC in peripheral blood are found in inflammatory diseases as well as in malignant tumors where they are supposed to be major contributors to mechanisms of tumor-associated tolerance. We investigated the frequency and function of MDSC in peripheral blood of melanoma patients and observed an accumulation of CD11b(+) CD33(+) CD14(+) HLA-DR(low) MDSC in all stages of disease (I-IV), including early stage I patients. Disease progression and enhanced tumor burden did not result in a further increase in frequencies or change in phenotype of MDSC. By investig…

Skin Neoplasmsmedicine.medical_treatmentCD14Sialic Acid Binding Ig-like Lectin 3CD33PopulationLipopolysaccharide ReceptorsReceptors Antigen T-CellDermatologyBiologyLymphocyte ActivationT-Lymphocytes RegulatoryBiochemistryImmune toleranceTetanus ToxoidHLA-DRmedicineHumansMyeloid CellsLymphocyte CounteducationMelanomaMolecular BiologyCells CulturedCell ProliferationNeoplasm Stagingeducation.field_of_studyCD11b AntigenMelanomaInterleukin-8HLA-DR AntigensImmunotherapymedicine.diseaseCoculture TechniquesTumor BurdenCase-Control StudiesImmunologyDisease ProgressionLeukocytes MononuclearMyeloid-derived Suppressor CellTumor EscapeExperimental Dermatology
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