Search results for "design."
showing 10 items of 5715 documents
Atherosclerosis as an inflammatory disease.
2011
In many ways, atherosclerosis is a chronic inflammatory disorder and this issue is confirmed by recent investigations of that have focused on inflammation, providing new insight into mechanisms of disease. Several recent studies have addressed the role of chemokines in leukocyte accumulation in atherosclerosis, extending our knowledge and understanding of the complex and cell type-specific functions of chemokines in atherosclerosis. Activated T-lymphocytes within the atherosclerotic vessel wall express the CD40 ligand surface molecule, known to play a major role in several immunological pathways. In addition to activated T-lymphocytes, functional CD40 and CD40L are coexpressed by human vasc…
Sequential analyses in coercive mother-child interaction: the predictability hypothesis in abusive versus nonabusive dyads.
1999
Abstract Objective: A two-fold purpose guided the present study: 1) To test the sequential relationship between the child’s aversive behavior and both the predictability and the compliance episodes, as well as the sequential relationship between these two mothering episodes proposed by the new predictability hypothesis (Wahler, Williams, & Cerezo, 1990) ; 2) to explore whether or not these patterns are specific to these dysfunctional dyads by using a nonabusive comparison group. Method: Fifty mother-child dyads, 25 abusive and 25 nonabusive, participated in this study. Lag sequential analyses were carried out on 302 hours of direct observation, 178 hours in the abusive group, and 124 in the…
Neighborhood characteristics and violence behind closed doors: The spatial overlap of child maltreatment and intimate partner violence
2018
In this study, we analyze first whether there is a common spatial distribution of child maltreatment (CM) and intimate partner violence (IPV), and second, whether the risks of CM and IPV are influenced by the same neighborhood characteristics, and if these risks spatially overlap. To this end we used geocoded data of CM referrals (N = 588) and IPV incidents (N = 1450) in the city of Valencia (Spain). As neighborhood proxies, we used 552 census block groups. Neighborhood characteristics analyzed at the aggregated level (census block groups) were: Neighborhood concentrated disadvantage (neighborhood economic status, neighborhood education level, and policing activity), immigrant concentration…
The impact of attachment distress on affect-centered mentalization: An experimental study in psychosomatic patients and healthy adults
2018
Introduction We investigated the impact of attachment distress on affect-centered mentalization in a clinical and a non-clinical sample, comparing mentalization in a baseline condition to mentalization under a condition of attachment distress. Methods The sample consisted of 127 adults who underwent inpatient psychosomatic treatment, and 34 mentally healthy adults. Affect-centered mentalization was assessed by analyzing participants’ narratives on interpersonal situations in a baseline condition with the Levels of Emotional Awareness Scale (LEAS), and an experimental condition inducing attachment distress with the Adult Attachment Projective Picture System (AAP). Unlike the LEAS, the AAP is…
Exergoeconomic analysis as support in decision-making for the design and operation of multiple chiller systems in air conditioning applications
2020
Abstract Multiple-chillers systems represent viable solutions for medium/large-scale air conditioning applications characterized by variable cooling demand. The energy efficiency of such systems is influenced by the number of chillers, the combination of cooling capacities, and the load-sharing among the units. Large efforts have been devoted to developing efficient operation strategies for these systems, but rules of thumb are usually adopted for selecting cooling capacities thus leaving room for energy and economic savings. In this paper, exergoeconomic analysis is proposed as a promising method to identify near-optimal design and operation strategies, due to the capability of exergoecono…
Modified LEAD System distractor to prevent tilting during alveolar distraction in the mandibular symphyseal region
2006
This report describes a simple modification of the LEAD System distractor that prevents tilting of the distractor rod, and consequent deviation of distraction direction, during alveolar distraction in the mandibular symphysis region.
Associations Between Built Environment Characteristics and Walking in Older Adults in a High-Density City: A Study From a Chinese Megacity
2020
The built environment is an important factor affecting physical activity, especially walkability. Walkability is used to characterize the user friendliness of outdoor physical activity. However, studies on walkability and physical activity are mainly concentrated on low-density Western cities. Study on the walkability of high-density cities in Asia, especially with the elderly, is seriously lacking. And walkability is often used as a composite indicator. This study mainly re-examines the relationship between the common indicators of walkability (population density, street connectivity, land-use mix, and retail density), transport-related walking, and leisure-time walking with older adults i…
New Strategy for the Stereoselective Synthesis of Fluorinated β-Amino Acids
2002
Racemic and chiral nonracemic alpha-substituted and alpha-unsubstituted beta-fluoroalkyl beta-amino acid derivatives 6 and 9 have been synthesized in two steps starting from fluorinated imidoyl chlorides 1 and ester enolates. This approach is based on the chemical reduction of previously obtained gamma-fluorinated beta-enamino esters 4 by using ZnI(2)/NaBH(4) in a nonchelated aprotic medium (dry CH(2)Cl(2)) as the reducing agent. A metal-chelated six-membered model has been suggested to explain the stereochemical outcome of the reduction reaction. The process takes place with high yields and with moderate to good diastereoselectivity. The best results related to diastereoselective reduction…
A computer program suitable for analysis of choice of categories in biomedical data recognition problems.
1980
The optimum choice of categories in problems of medical data recognition is governed by the choice of categories, the selection of appropriate features, and by the choice of a loss function. Under these circumstances it is often difficult to find out the suitable classification scheme. The computer program described here serves for the design of the optimum recognition procedure. The Bayes rule is used as decision rule. A criterion for the comparison of different choice of categories is given. The program can be performed after estimation of the underlying prior probabilities and the conditional densities obtained from a training set, and before testing the decision rule with real data.
ECO-design of solar driven systems: A performance comparison between the Italian and the Brazilian context
2013
The paper shows a comparative analysis of the performances of two typologies of solar assisted cooling systems for building applications. In particular, Life Cycle Assessment (LCA) methodology is applied to assess the energy and environmental impacts of solar-assisted, heat-driven chillers and conventional compression chillers driven by grid-connected and stand-alone photovoltaic configurations. LCA is applied in compliance with the international standards of ISO 14040. System boundaries are defined following a “cradle to grave” approach, taking into account all the life-cycle phases including the raw materials supply, the production of the components of the plant, the operation and mainten…