Search results for "design."

Quantitative assessment of the parameters linked to the blending between reclaimed asphalt binder and recycling agent: A literature review

2020

Abstract The lack of understanding the mechanisms governing the interaction between reclaimed asphalt binder (RAb) 1 and recycling agents is one of the technical issues that still need to be resolved when high amount of reclaimed asphalt (RA) 2 is used in a new recycled asphalt mixture (RAM). Due to important role of RAb in that interaction and increased used of RA, it becomes necessary to have a way to classify RA, as any other material used in asphalt mixture production. It is very important to determine how much RAb is active by itself (DoA) 3 , but also to determine how much RAb can be considered available for a mix design of RAM (DoAv) 4 when a recycling agent is used. Finally, since t…

A Case for Raising the Camera: A Driving Simulator Test of Camera-Monitor Systems

2021

Objective This experiment provides a first-of-its-kind driving-simulator study to investigate the feasibility of camera-monitor systems (CMS) with displaced side-mounted cameras in sedans. Background Among the increasing number of studies investigating the replacement of side-mounted rearview mirrors with CMS, the placement of side-mounted cameras has been largely neglected. Moreover, user preferences with respect to camera placement have not been validated in a driving simulator. Past research merely has shown that the vertical camera position can affect distance perception. Method In a driving simulator experiment, we investigated the effects of rearward camera placement on driver accepta…

Developing design knowledge and a conceptual model for virtual reality learning environments

2021

This chapter focuses on applying design science research for virtual reality learning environment (VRLE) design processes. Six selected case studies are presented in the context of VRLEs. The case selections were analyzed in terms of their contributions to design knowledge. The objective of this book chapter is twofold: 1) for researchers, the design knowledge contributions of case studies are highlighted for future reference, and 2) for developers and practitioners, design principles are presented for the development of VRLEs. The final outcome of the present study is a conceptual model describing the current design knowledge in the field of VRLEs and identifying the research gaps that sho…

Dynamic-shared Pharmacophore Approach as Tool to Design New Allosteric PRC2 Inhibitors, Targeting EED Binding Pocket.

2020

Abstract: The Polycomb Repressive complex 2 (PRC2) maintains a repressive chromatin state and silences many genes, acting as methylase on histone tails. This enzyme was found overexpressed in many types of cancer. In this work, we have set up a Computer-Aided Drug Design approach based on the allosteric modulation of PRC2. In order to minimize the possible bias derived from using a single set of coordinates within the protein-ligand complex, a dynamic workflow was developed. In details, molecular dynamic was used as tool to identify the most significant ligand-protein interactions from several crystallized protein structures. The identified features were used for the creation of dynamic pha…

An omics perspective to the molecular mechanisms of anticancer metallo-drugs in the computational microscope era

2017

Introduction: Metallo-drugs have attracted enormous interest for cancer treatment. The achievements of this drug-type are summarized by the success story of cisplatin. That being said, there have been many drawbacks with its clinical use, which prompted decades worth of research efforts to move towards safer and more effective agents, either containing platinum or different metals. Areas covered: In this review, the authors provide an atomistic picture of the molecular mechanisms involving selected metallo-drugs from structural and molecular simulation studies. They also provide an omics perspective, pointing out many unsettled aspects of the most relevant families of metallo-drugs at an ep…

Guest Editors' Introduction to the Special Section on Algorithms in Bioinformatics

2008

How neurophysiological measures can be used to enhance the evaluation of remote tower solutions

2019

New solutions in operational environments are often, among objective measurements, evaluated by using subjective assessment and judgment from experts. Anyhow, it has been demonstrated that subjective measures suffer from poor resolution due to a high intra and inter-operator variability. Also, performance measures, if available, could provide just partial information, since an operator could achieve the same performance but experiencing a different workload. In this study, we aimed to demonstrate: (i) the higher resolution of neurophysiological measures in comparison to subjective ones; and (ii) how the simultaneous employment of neurophysiological measures and behavioral ones could allow a…

Modelling and Analysis of Non-Stationary Multipath Fading Channels with Time-Variant Angles of Arrival

2017

In mobile radio channel modelling, it is generally assumed that the angles of arrival (AOAs) are independent of time. This assumption does in general not agree with real-world channels in which the AOAs vary with the position of a moving receiver. In this paper, we first present a mathematical model for the time-variant AOAs. This model serves as the basis for the development of two non-stationary multipath fading channels models. The statistical properties of both channel models are analysed with emphasis on the time-dependent autocorrelation function (ACF), time-dependent mean Doppler shift, time-dependent Doppler spread, and the Wigner-Ville spectrum. It is shown that these characteristi…

Representation of NURBS surfaces by Controlled Iterated Functions System automata

2019

Iterated Function Systems (IFS) are a standard tool to generate fractal shapes. In a more general way, they can represent most of standard surfaces like Bézier or B-Spline surfaces known as self-similar surfaces. Controlled Iterated Function Systems (CIFS) are an extension of IFS based on automata. CIFS are basically multi-states IFS, they can handle all IFS shapes but can also manage multi self-similar shapes. For example CIFS can describe subdivision surfaces around extraordinary vertices whereas IFS cannot. Having a common CIFS formalism facilitates the development of generic methods to manage interactions (junctions, differences...) between objects of different natures.This work focuses…

Parallelizing Epistasis Detection in GWAS on FPGA and GPU-Accelerated Computing Systems

2015

This is a post-peer-review, pre-copyedit version of an article published in IEEE - ACM Transactions on Computational Biology and Bioinformatics. The final authenticated version is available online at: http://dx.doi.org/10.1109/TCBB.2015.2389958 [Abstract] High-throughput genotyping technologies (such as SNP-arrays) allow the rapid collection of up to a few million genetic markers of an individual. Detecting epistasis (based on 2-SNP interactions) in Genome-Wide Association Studies is an important but time consuming operation since statistical computations have to be performed for each pair of measured markers. Computational methods to detect epistasis therefore suffer from prohibitively lon…