Search results for "developmental"

Towards gender awareness in couple therapy and in treatment of intimate partner violence

2017

Gender is the most pervasive classification of individuals and thus strongly defines couple relationships. Cultural discourses on couple relationships reproduce hierarchical gender differences, and couple distress is often linked to gendered power inequalities. At worst, gender is the basis for intimate partner violence (IPV). Generally, however, therapeutic interventions do not address the issues of gender and gendered power. This paper discusses the meaning and functions of gender in the context of couple therapy, in particular for IPV. It is argued that the therapist needs to be skilled in discursive deconstruction to be able not only to address the client’s situation as an individual ex…

Health Promotion in Sport Coaching: Coaches and Young Male Athletes’ Evaluations on the Health Promotion Activity of Coaches

2015

Sport coaches have paradoxical attitudes towards addressing health promotion as a part of their coaching practice: health is recognized as an important factor, but not greatly invested in. Overall, the extent to which youth sport coaches take health promotion into account has been unclear. Therefore, it is the intention of this study to clarify this situation. The results show that coaches evaluate their own activity on health promotion as being relatively active, whereas young male athletes' evaluations reveal a wide gap in how they perceived the coaches' activity. Young male athletes perceived their coaches as being substantially more passive in comparison to coaches' self-evaluations. T…

Toward modernizing the systematic review pipeline in genetics: efficient updating via data mining

2012

Purpose: The aim of this study was to demonstrate that modern data mining tools can be used as one step in reducing the labor necessary to produce and maintain systematic reviews. Methods: We used four continuously updated, manually curated resources that summarize MEDLINE-indexed articles in entire fields using systematic review methods (PDGene, AlzGene, and SzGene for genetic determinants of Parkinson disease, Alzheimer disease, and schizophrenia, respectively; and the Tufts Cost-Effectiveness Analysis (CEA) Registry for cost-effectiveness analyses). In each data set, we trained a classification model on citations screened up until 2009. We then evaluated the ability of the model to class…

FRIGHTENING OF CHILDREN BY PARENTS AND ITS CONSEQUENCES

2018

The article attempts to generalize data on such a complex pedagogical and psychological phenomenon as the deliberate frightening of children by adults. Despite an obvious or apparent harm, it is still included in the established set of methods of family education. In our study, we studied the origins of this phenomenon, the degree of its prevalence in the practice of family education at the present time, and the consequences of using threats in the process of education in the assessments of the adults who were brought up in this way.To achieve the research objectives, a number of former children who were frightened in childhood by their parents, the content of adults’ threats, the motives f…

On the Choice of the Extracellular Vesicles for Therapeutic Purposes

2019

Extracellular vesicles (EVs) are lipid membrane vesicles released by all human cells and are widely recognized to be involved in many cellular processes, both in physiological and pathological conditions. They are mediators of cell-cell communication, at both paracrine and systemic levels, and therefore they are active players in cell differentiation, tissue homeostasis, and organ remodeling. Due to their ability to serve as a cargo for proteins, lipids, and nucleic acids, which often reflects the cellular source, they should be considered the future of the natural nanodelivery of bio-compounds. To date, natural nanovesicles, such as exosomes, have been shown to represent a source of diseas…

MTOR inhibitor-based combination therapies for pancreatic cancer

2018

Background: Although the mechanistic target of rapamycin (MTOR) kinase, included in the mTORC1 and mTORC2 signalling hubs, has been demonstrated to be active in a significant fraction of patients with pancreatic ductal adenocarcinoma (PDAC), the value of the kinase as a therapeutic target needs further clarification. Methods: We used Mtor floxed mice to analyse the function of the kinase in context of the pancreas at the genetic level. Using a dual-recombinase system, which is based on the flippase-FRT (Flp-FRT) and Cre-loxP recombination technologies, we generated a novel cellular model, allowing the genetic analysis of MTOR functions in tumour maintenance. Cross-species validation and pha…

Self-reported reflective functioning mediates the association between attachment insecurity and well-being among psychotherapists.

2020

Objective: Subjective well-being is a crucial variable for mental health practitioners. This study examines the influence of therapists’ attachment dimensions and self-reported reflective functioning on their perceived well-being. Further, it examines if reflective functioning mediates the association between attachment insecurity and well-being. Method: A total of 416 experienced psychotherapists were enrolled in this cross-sectional study, and completed self-report measures of attachment insecurity, reflective functioning, and well-being. We tested the hypothesized mediation model with path analysis that examined indirect effects. Results: Both attachment anxiety and avoidance dimensions …

Protein tyrosine nitration and thiol oxidation by peroxynitrite-strategies to prevent these oxidative modifications.

2013

The reaction product of nitric oxide and superoxide, peroxynitrite, is a potent biological oxidant. The most important oxidative protein modifications described for peroxynitrite are cysteine-thiol oxidation and tyrosine nitration. We have previously demonstrated that intrinsic heme-thiolate (P450)-dependent enzymatic catalysis increases the nitration of tyrosine 430 in prostacyclin synthase and results in loss of activity which contributes to endothelial dysfunction. We here report the sensitive peroxynitrite-dependent nitration of an over-expressed and partially purified human prostacyclin synthase (3.3 μM) with an EC50 value of 5 μM. Microsomal thiols in these preparations effectively co…

Editorial: Thymic Epithelial Cells: New Insights Into the Essential Driving Force of T-Cell Differentiation.

2021

Kotimaisilla kielillä julkaistu tutkimus palvelee monia

2022

Pääkirjoitus 3/2022