Search results for "diagnostics."

Experimental evidence on microwave induced electron losses from ECRIS plasma

2018

The balance between warm and hot (>1 keV) electron density and their losses from the magnetic confinement system of an Electron Cyclotron Resonance Ion Source (ECRIS) plasma is considered to be one of the main factors determining the rate of the high charge state ion production. One of the key loss channels for heated electrons is thought to be induced by the injected microwaves. While this loss mechanism, referred to as rf-induced pitch angle scattering, has been studied theoretically and with computational tools, direct experimental evidence of its significance in minimum-B ECRIS plasmas remains limited. In this work, experimental evidence of microwave induced electron losses in the axial…

High-resolution, accurate multiple-reflection time-of-flight mass spectrometry for short-lived, exotic nuclei of a few events in their ground and low…

2019

Physical review / C covering nuclear physics 99(6), 064313 (2019). doi:10.1103/PhysRevC.99.064313

Performance Comparison of a Flow Cytometry-based and Two Commercial Chemiluminescent Immunoassays for Detection and Quantification of Antibodies Bind…

2021

ABSTRACTThe performance of a laboratory-developed quantitative IgG/IgA flow cytometry-based immunoassay (FCI) using Jurkat T cells stably expressing full-length native S protein was compared against Elecsys® electrochemiluminiscent (ECLIA) Anti-SARS-CoV-2 S (Roche Diagnostics, Pleasanton, CA, USA), and LIAISON® SARS-CoV-2 TrimericS IgG chemiluminiscent assay (CLIA) (Diasorin S.p.a, Saluggia, IT) for detection and quantitation of SARS-CoV-2-specific antibodies. A total of 225 serum/plasma specimens from 120 acute or convalescent COVID-19 individuals were included. Overall, IgG/IgA-FCI yielded the highest number of positives (n=179), followed by IgA-FCI (n=177), Roche ECLIA (n=175), IgG-FCI (…

“Ultra-sensitive” cardiac troponins: Requirements for effective implementation in clinical practice

2018

The measurement of cardiac troponins, either cardiac troponin I or T, has become the culprit of clinical decision making in patients with suspected acute coronary syndrome (ACS), especially in those with non-ST elevation myocardial infarction (NSTEMI). The leading analytical mainstays of cardiac troponin immunoassays include the limit of blank (LoB), limit of detection (LoD), functional sensitivity, the 99th percentile of a healthy reference population, along with the percentage of “ostensibly healthy” subjects displaying measurable values 50% in the general healthy population. The very recent commercialization of methods with further improved analytical sensitivity (i.e., “ultra-sensitive”…

Intraoperative DNA methylation classification of brain tumors impacts neurosurgical strategy

2021

Abstract Background Brain tumor surgery must balance the benefit of maximal resection against the risk of inflicting severe damage. The impact of increased resection is diagnosis-specific. However, the precise diagnosis is typically uncertain at surgery due to limitations of imaging and intraoperative histomorphological methods. Novel and accurate strategies for brain tumor classification are necessary to support personalized intraoperative neurosurgical treatment decisions. Here, we describe a fast and cost-efficient workflow for intraoperative classification of brain tumors based on DNA methylation profiles generated by low coverage nanopore sequencing and machine learning algorithms. Met…

Effect of Intravenous IgM-Enriched Immunoglobulins on Presepsin and Other Sepsis Biomarkers

2021

Patients in septic shock with low IgG and IgM serum concentrations have higher mortality rates compared to those with normal immunoglobulin levels and, therefore, there is a rational explanation to administer intravenous IgM-enriched immunoglobulins to septic patients in ICU. Aim of this study is to evaluate the effectiveness of intravenous IgM-enriched immunoglobulins in decreasing several sepsis biomarker concentrations. 26 sepsis patients were enrolled in this observational cohort study and Nitric Oxide, Endocan, Pentraxin and presepsin serum levels were measured during their first 3 days of ICU stay. The use of intravenous IgM-enriched immunoglobulins did not influence the temporal evol…

Die Lungentuberkulose – aktuelle radiologische Diagnostik einer alten Krankheit

2000

Inzidenz. Abnehmende Inzidenzen aktiver Tuberkulose in den Industrielandern haben diese Erkrankung aus dem Bewusstsein vieler verdrangt. Dennoch stellt die Tuberkulose weiterhin weltweit die am haufigsten zum Tode fuhrende Infektionskrankheit dar. In den Industrielandern tragen Faktoren wie Einwanderungsbewegungen, zunehmende Verarmung und die Zunahme immunsupprimierter Patienten, insbesondere durch die HIV-Epidemie, dazu bei, dass ein Reservoir fur die Tuberkulose aufrecht erhalten wird. Diagnose. Eine fruhzeitige Diagnose ist wegen der spezifischen Therapiemoglichkeiten entscheidend fur den Krankheitsverlauf; im Falle von multiresistenten Stammen ist sie wichtig zur Verhinderung einer wei…

Radiation engineered nanogels as platform for next-generation of medical diagnostics and therapeutics

2010

Ion beam intensity and phase space measurement techniques for ion sources.

2022

Ion sources produce beams used in accelerators and other applications. Both development and use of ion sources need beam diagnostics to probe the plasma processes and beam formation for optimization purposes and to produce beam parameters needed for transport tuning. These diagnostics include beam intensity measurements usually carried out with Faraday cups or inductive pickups, magnetic separation, profile measurements with scintillation screens and wires, and phase space measurements with different types of emittance scanners. peerReviewed

Dynamic regimes of cyclotron instability in the afterglow mode of minimum-B electron cyclotron resonance ion source plasma

2016

The paper is concerned with the dynamic regimes of cyclotron instabilities in non-equilibrium plasma of a minimum-B electron cyclotron resonance ion source operated in pulsed mode. The instability appears in decaying ion source plasma shortly (1–10 ms) after switching off the microwave radiation of the klystron, and manifests itself in the form of powerful pulses of electromagnetic emission associated with precipitation of high-energy electrons along the magnetic field lines. Recently it was shown that this plasma instability causes perturbations of the extracted ion current, which limits the performance of the ion source and generates strong bursts of bremsstrahlung emission. In this artic…