Search results for "dialysi"
showing 10 items of 555 documents
Heparin induces an accumulation of atherogenic lipoproteins during hemodialysis in normolipidemic end-stage renal disease patients
2014
Dyslipidemias may account for the excess of cardiovascular mortality in end-stage renal disease (ESRD). Lipoprotein studies in ESRD patients are usually relative to prehemodialysis samples even if significative changes may occur after dialysis. In this study, we aimed to investigate the effects of ESRD on triglyceride-rich lipoproteins (TRL) subpopulations distribution and acute change following hemodialytic procedures, including the relative contribution of heparin administration. We selected a group of normolipidemic male middle-aged ESRD patients free of any concomitant disease affecting lipoprotein remnant metabolism compared with controls. We separated TRL subfractions according to den…
Baclofenintoxikation bei chronischer Hämodialyse und Nierentransplantation
2008
Fourteen days after renal transplantation, at first gave with good transplant function, a 36-year-old woman developed neurogenic dysfunction of bladder emptying. This was treated with baclofen, 5 mg three times daily by mouth. Between the 7th and 10th treatment day she progressively developed an organic psychotic syndrome and increasing respiratory paralysis after the onset of renal failure, associated with rejection of the transplanted kidney which required dialysis. Plasma concentration of baclofen was 565 ng/ml (therapeutic range 80-400 ng/ml). After discontinuing the drug and renewed haemodialysis the baclofen level rapidly fell and the symptoms receded. In a second case, a 57-year-old …
Enhancement of Hippocampal Acetylcholine Release by Local Ethanol Infusion
1997
Among the multiple pathological changes in the CNS which are associated with ethanol intoxication (1), an impairment of cognitive functions is one of the most consistent findings. This impairment may be due to a damage of central cholinergic systems. Long-term administration of ethanol causes neurodegenerative changes in the cholinergic basal fore-brain neurons of rats and humans (2), and in the rat, these changes are accompanied by a reduction of the release of acetylcholine (ACh) in the hippocampal and cortical target regions of basal forebrain neurons (3). Moreover, experimental studies have documented that ethanol-induced dysfunctions of memory and learning can be ameliorated by cholino…
On the modelling of an Acid/Base Flow Battery: An innovative electrical energy storage device based on pH and salinity gradients
2020
Abstract Electrical energy storage can enhance the efficiency in the use of fluctuating renewable sources, e.g. solar and wind energy. The Acid/Base Flow Battery is an innovative and sustainable process to store electrical energy in the form of pH and salinity gradients via electrodialytic reversible techniques. Two electromembrane processes are involved: Bipolar Membrane Electrodialysis during the charge phase and its opposite, Bipolar Membrane Reverse Electrodialysis, during the discharge phase. For the first time, the present work aims at predicting the performance of this energy storage device via the development of a dynamic mathematical model based on a multi-scale approach with distr…
Prevalence of biliary lithiasis in a Sicilian population of hemodialysis patients
2001
Studies performed to date on the prevalence of biliary lithiasis (BL) in chronic renal failure patients on hemodialysis (HD) have given contradictory results. The aims of the present study were to evaluate the prevalence of BL and its main associated risk factors in a population of hemodialysis patients, and to compare the results with those we had obtained previously in an overt population of the same zone. The study included 171 patients (83 M, 88 F), mean age 62.5 years and mean duration of dialysis 66.7 months. The screening protocol also included body mass index (BMI), a number of biochemical parameters and an ultrasound scan of the gallbladder and biliary tract. The general prevalence…
On the modelling of an Acid/Base Flow battery: an innovative electrical energy storage device based on pH and salinity gradients
2019
The Acid/Base Flow Battery (AB-FB) is an innovative and sustainable way to store electric energy. It can theoretically guarantee an energy density of about 11 kWh/m3, which is higher than that provided by pumped hydropower, osmotic energy storage and compressed air. The AB-FB stores energy as pH and salinity gradients by employing a stack provided with (i) channels, hosting the solutions at difference pH and concentrations, separated by (ii) monopolar and bipolar ion exchange membranes. Two different membrane processes are involved: the Bipolar Membrane Electrodialysis (ED-BM) as charging step and its opposite, Bipolar Membrane Reverse Electrodialysis (RED-BM) as discharging step. The prese…
Feeding enhances extracellular lactate of local origin in the rostromedial hypothalamus but not in the cerebellum.
1999
Abstract The use of brain microdialysis together with chronic vascular catheterization allowed us to assay extracellular fluid lactate (ECF L ) in both the ventromedial–paraventricular (VMH–PVN) area of the hypothalamus and the cerebellum, in parallel with measures of plasma levels, and in relation to food intake. A 45 min scheduled meal increased VMH–PVN ECF L by 28%. This increase was not observed in the cerebellum. The prandial increase in plasma glucose (43%, from 4.74 to 6.77 mM) and lactate (84%, from 0.83 to 1.53 mM) showed a different temporal pattern and lasted longer than that of the ECF L . Glucose delivery by reverse dialysis for 45 min into the VMH–PVN area increased ECF L by 4…
Haemostasis in chronic kidney disease
2013
The coagulation system has gained much interest again as new anticoagulatory substances have been introduced into clinical practice. Especially patients with renal failure are likely candidates for such a therapy as they often experience significant comorbidity including cardiovascular diseases that require anticoagulation. Patients with renal failure on new anticoagulants have experienced excessive bleeding which can be related to a changed pharmacokinetic profile of the compounds. However, the coagulation system itself, even without any interference with coagulation modifying drugs, is already profoundly changed during renal failure. Coagulation disorders with either episodes of severe bl…
Therapeutic properties of haemodialysis and blood exchange transfusion in organophosphate poisoning
1976
Human blood was contaminated with nitrostigmine, dimethoate and demeton-S-methyl sulfoxide. It was then dialysed, concentrations of organophosphates were determined and dialysance values calculated. The influence of blood exchange transfusion on poison elimination as well as on the cholinesterase activity of blood, brain and muscle was studied in rats poisoned with nitrostigmine. Haemodialysis was found to be quite an effective method for eliminating demeton-S-methyl sulfoxide and dimethoate, dialysance values of 52.98 ml/min and 59.07 ml/min being found for demeton-S-methyl sulfoxide and dimethoate respectively. Nitrostigmine could not be removed by haemodialysis. These findings suggest th…
P0877ASSOCIATIONS OF DISORDERS IN BONE MINERAL PARAMETERS WITH MORTALITY IN STAGE 4 AND 5 CKD: INSIGHTS FROM THE PECERA STUDY
2020
Abstract Background and Aims Abnormalities of bone mineral parameters are associated with increased mortality in patients on dialysis, but their effects and the optimal range of these biomarkers are less well characterized in non-dialysis chronic kidney disease (CKD). Method PECERA (Collaborative Study Project in Patients with Advanced Chronic Kidney Disease) is a 3-year, multicentre, open-cohort, prospective study carried out in 995 adult patients with CKD stages 4-5 not on dialysis enrolled in 2007-09 from 12 centres in Spain. Associations between levels of serum calcium (corrected for serum albumin), phosphate, and intact parathyroid hormone (iPTH) and all-cause mortality were examined u…