Search results for "diary"
showing 10 items of 173 documents
Synthesis and biological evaluation of 4-nitro-substituted 1, 3-diaryltriazenes as a novel class of potent antitumor agents
2011
Abstract We describe the synthesis and biological activity of a new class of 1,3-diaryltriazenes, namely 4-nitro-substituted 1,3-diaryltriazenes. Structure–activity relationship analysis reveals that 1,3-diaryltriazenes can be modified from inactive to highly cytotoxic compounds by the introduction of two nitro groups at the para positions of benzene rings and two additional electron-withdrawing groups (bromo, chloro, trifluoromethyl or fluoro substituents) at their ortho position. In order to increase the solubility of the modified compounds, we introduced various acyl groups to their triazene nitrogen. The results of LC-MS/MS analysis showed that N -acyltriazenes can be considered as prod…
Protonenvermittelter Ringschluss eines negativ photochromen, Azulen‐basierten Diarylethens
2020
Auf Protonen ansprechende photochrome Moleküle sind aufgrund ihrer Fähigkeit, auf nicht-invasive schnelle optische Stimuli zu reagieren, und wegen der ubiquitären Bedeutung von Protonierungs- und Deprotonierungsprozessen, sehr interessant. Üblicherweise befinden sich die sauren/basischen Stellen dieser Moleküle an Heteroatomen, die orthogonal zum photoaktiven π-Zentrum ausgerichtet sind. In dieser Arbeit wird Azulen, ein protonensensitiver reiner Kohlenwasserstoff, in das Gerüst eines Diarylethen-Photoschalters eingebaut. Dieser zeigt einen bisher ungekannten, protonenvermittelten, negativ photochromen Ringschluss. Veränderungen seiner optischen Eigenschaften durch Protonierung, sowohl in d…
A transaction cost analysis of staffing decisions in international operations
2005
Abstract This paper analyzes staffing decisions in foreign subsidiaries from the perspective of transaction cost theory. We focus on the ex post transaction costs of the employment relation. Specifically, we look at the monitoring, bonding, maladaptation, and bargaining costs of conducting activities in specific subsidiaries in a foreign country. We hypothesize that the transaction costs of using expatriates are lower than those generated by local employees, especially in the higher managerial echelons of foreign subsidiaries, but also that costs can be reduced as individuals become more experienced. We also conjecture that ex post transaction costs are influenced by cultural differences be…
Sources of Financing for Social Entrepreneurship
2021
The following chapter discusses the main forms of financing for social entrepreneurship. The ultimate goal of social entrepreneurship is to create social value. To this end, financial means act as intermediaries to achieve this goal. These means must be aligned with the mission, vision, and values of the new venture. Therefore, there must be certain parallelism in the modus operandi of the entrepreneurial companies and the institutions supporting their launch in the market with economic resources. Since social entrepreneurship arises as a new paradigm to create the business, its financing sources represent a new method to obtain economic resources. Ethical banking is the core concept of the…
Crowdfunding and Social Entrepreneurship: Spotlight on Intermediaries
2019
This study contributes to the literature by describing how crowdfunding platforms that host social entrepreneurship projects build and preserve legitimacy. We study three intermediaries, analyzing the actions they take to ensure that creators and funders perceive crowdfunding as a trustworthy form of alternative finance. This study shows that the legitimacy that funders ascribe to a project&rsquo
Cooperation in Rural Areas as a Local System Development Opportunity
2017
The development of rural areas requires the adoption of technology innovation and market approach strategies without departing from the specific features of local production systems, such as agricultural practices and the wealth of knowledge of operators. It is even better the exploitation of these resources to characterize the competitive positioning of territorial systems. In this framework, the cooperative Rinascita, which works in an internal rural area of Sicily region (Southern Italy), represents an attempt to maintain agricultural activities, traditions and rural culture as well as to promote and contribute to the development of the area by giving value to and promoting, a typical lo…
Co‐parenting through subsidiaries: A model of value creation in the multinational firm
2017
Research summary We analyze a novel way to configure and manage multinational networks and propose a model of "co-parenting", characterized by the sharing of parenting roles and distribution of responsibilities between two units. We develop our argument around the notion of the springboard subsidiary, an operating subsidiary which assumes headquarters’ functions since it shares greater institutional closeness with both the headquarters’ country as well as with the host region. Based upon qualitative data, our inductive model revolves around three stages: establishment, consolidation and maturity, each of which reflects distinct roles and loci of decision making among the three actors involv…
«L’ESALTAZIONE DEL VERO E LA PROSOPOPEA DELLE FORZE INANIMATE»:L’ALTROVE DI ORIO VERGANI
2020
The fact that Orio Vergani, journalist, writer and reporter, was, as Montale suggested, "a daily reader of life" is testified to by the "alluvial mass" of writings through which he unravels an itinerary of adhesion to Fascism lived, close to the Second World War, in a problematic way and marked by a pervasive conscientious turmoil in his inventive and diaristic writing. From the recurring knots that permeate the inventive plot of the stories in the posthumous volume "Storie per quattro stagioni" (Stories for four seasons), from 1920 onwards, a restless inner journey is sketched out, culminating, between 1950 and 1959, in the sharp diaristic 'narration' of Misure del tempo (Measures of the t…
<i>Datasharing</i>: guía práctica para compartir datos de investigación
2013
To associate research data to the published results favors their reuse by the scientific community, but this does not afford sufficient guarantees of preservation. To store them in databases solves this contingency and provides visibility, but in Spain there are not many services of this kind. For this reason, we describe, evaluate and discuss the pros and cons of foreign multidisciplinary data repositories that can be useful for researchers and information managers: Dryad, Figshare, Zenodo and Dataverse. It is still early to choose optimally and definitively one or the other application, so we conclude with recommendations to guide the user community and intermediaries.