Search results for "digestive"

Thymidylate synthase polymorphism and microsatellite instability: association in colorectal cancer.

2005

5-Fluorouracil (5FU) is the main drug used for the treatment of colorectal cancer (CRC) and Thymidilate Synthase (TS) is its target enzyme. TS gene has regulatory tandemly repeated sequences in its 5'' and 3''untraslated region (5''-3'' UTR). CRC often shows a kind of genomic instability called Microsatellite Instability (MSI) that is associated with TS levels and survival. Our data show that the genotype 2R/2R (homozygosity for 2 tandem repeat sequences in the 5''UTR) is more frequently associated with MSI+ and lower TS levels. More over we did not find any significant association between the 2R/3R (heterozygosity for 2 and 3 tandem repeat sequences in the 5''UTR) and 3R/3R (homozygosity f…

Infrequent promoter methylation of the MGMT gene in liver metastases from uveal melanoma.

2008

Uveal melanoma is associated with a high mortality rate once metastases occur, with over >90% of metastatic patients dying within less than 1 year from metastases to the liver. The intraarterial hepatic (iah) administration of the alkylating agent fotemustine holds some promise with response rates of 36% and median survival of 15 months. Here, we investigated whether the DNA-repair-protein MGMT may be involved in the variability of response to fotemustine and temozolomide in uveal melanoma. Epigenetic inactivation of MGMT has been demonstrated to be a predictive marker for benefit from alkylating agent therapy in glioblastoma. We found a methylated MGMT promoter in 6% of liver metastases fr…

The role of NFkappaB inducing kinase (NIK) in the pathogenicity of EAE

2014

pathways (PTPN6, SLC3A2, VAV3, DDR1) and modulators of oxidative stress (MT1A, HMOX1, SLC30A1) were also significantly affected by the CBD treatment. The microarray results were confirmed using qPCR on selected gene targets. Immunoblotting demonstrated that CBD reduces IL-17 by decreasing STAT3 phosphorylation and increasing that of STAT5. In conclusion, our observations increase our understanding of the mechanisms of the anti-inflammatory activities of CBD.

Bidrar idrettsarenaen til et helsefremmende kosthold? : En analyse av måltidsmønster, mat- og drikkeinntak og identifisering av potensielle påvirknin…

2017

Masteroppgave folkehelsevitenskap ME516 - Universitetet i Agder 2017 Background: Diet during adolescence is important for health in short and long term. The sports area is considered as a potential setting for creating a health promoting environment, since many adolescents are participating in organized sport. Purpose: The aim of this study was to examine differences in meal pattern, food and beverage consumption adolescents attending a soccer tournament compared with intake in everyday life. Method: The qualitative research conducted through semi-structured interviews (n = 7) consisting of soccer coaches, management of the tournament and sponsors of the tournament. Furthermore, a cross-sec…

Possible Effects of a Free School Meal on School Environment: The School Meal Intervention in Norway

2021

Evidence suggests that a free school meal can improve children and adolescent diet, social environment, concentration, and school performance. This study aimed to investigate possible effects of a free, healthy school meal among students that usually eat packed meals on behavioral issues, inactiveness, self-efficacy, school enjoyment and classroom environment. A school meal according to the dietary guidelines was served to students in the intervention group (n=55) for one year. A control group consumed packed meals as usual (n=109). Students (10-12 years) responded to a questionnaire at baseline and after one year. We used linear regression analyses and did not find significant effects of a…

Barns matmot 2.0 : Diet, development, and food neophobia in early years. How to promote healthy diets in a kindergarten setting

2021

Early diet has a profound impact on a child’s development, growth, and future health. A varied diet with a high intake of vegetables is positive in several domains of health. In Norway, as in many other countries, the intake of vegetables is too low among both children and adults. An important barrier to vegetable intake in children is food neophobia. Food neophobia, meaning unwillingness to try unfamiliar foods, is a trait that is most explicit in children between two and six years of age. As this age period is important for the development of food preferences and lifelong dietary habits, understanding which factors are related to food neophobia in early age is important to know how to bes…

Extrahepatic Morbidity and Mortality of Chronic Hepatitis C

2015

Chronic hepatitis C virus (HCV) infection is associated with several extra-hepatic manifestations. Patients with HCV may develop mixed cryoglobulinemia and its sequelae, ranging from cutaneous and visceral vasculitis to glomerulonephritis and B cell non-Hodgkin’s lymphoma. HCV-infected patients have increased rates of insulin resistance, diabetes and atherosclerosis, which may lead to increased cardiovascular morbidity and mortality. Neurologic manifestations of HCV infection include fatigue and cognitive impairment. The mechanisms causing the extra-hepatic effects of HCV infection are likely multifactorial and may include endocrine effects, HCV replication in extra-hepatic cells, or a heig…

A New Early Cambrian Lobopod-Bearing Animal (Murero, Spain) and the Problem of the Ecdysozoan Early Diversification

2011

A new xenusian, Mureropodia apae gen. and sp. nov., is found in the lower Cambrian of the Murero Lagerstatte in the Cadenas Ibericas, NE Spain. In Mureropodia, the lobopod length/body width ratio reveals that this animal hardly was able to walk on the bottom surface. Possibly, it could use the limbs for anchoring the body to the substrate. A well-developed dermomuscular sac of circular and longitudinal muscular systems as well as probably retractile proboscis fit such an interpretation. The ground plan of the Xenusia includes a vermiform body; a proboscis or mouth cone; paired lobopods with claws; a cuticle displaying a repeated anatomical patterning; a straight digestive tract with termina…

Comparative WSSV infection routes in the shrimp genera Marsupenaeus and Palaemon.

2005

The Asian Taenia and the possibility of cysticercosis

2000

In certain Asian countries, a third form of human Taenia, also known as the Asian Taenia, has been discovered. This Asian Taenia seems to be an intermediate between Taenia solium and T. saginata since in morphological terms it is similar to T. saginata, yet biologically, as it uses the same intermediate host (pigs), it is more akin to T. solium. Taenia solium causes human cysticercosis, while T. saginata does not. It is not known whether the Asian taeniid is able to develop to the larval stage in humans or not. The arguments proposed by those authors who consider it unlikely that the Asian Taenia causes human cysticercosis are: (a) its molecular similarities with T. saginata; (b) the absenc…