Search results for "dire"
showing 10 items of 3084 documents
Los sistemas de gestión de la calidad total y las practicas de alto rendimiento como facilitadores del desarrollo de capacidades directivas y del pro…
2022
Las empresas familiares tienen un importante peso sobre nuestra economía, siendo el eje vertebral de la economía del mercado y aportando al Producto Interior Bruto algo más del 65%. Sin embargo y a pesar de su relevancia sobre la economía en general y el sector turístico en particular, presentan una elevada mortalidad, dado que tan sólo entre el 5 y el 15% alcanzan la tercera generación en manos del grupo familiar fundador. Este escenario evidencia que este tipo de organizaciones mantienen una serie de problemas endémicos y organizativos que requieren de un profundo análisis. El proceso de sucesión es uno de los retos más relevantes al cual toda empresa familiar se debe enfrentar, además, e…
Irresponsabilidad social corporativa: el papel de las élites directivas
2018
La Irresponsabilidad Social Corporativa goza de una gran relevancia pues en los últimos tiempos están apareciendo cada vez más casos que evidencian la doble moral de las empresas: esto es, empresas acusadas de comportamientos irresponsables están adoptando, simultáneamente, compromisos en materia social y medioambiental, con los grupos de interés y con la sociedad. Este sería el caso, por ejemplo, de la empresa alemana Volkswagen. Esta empresa, en el mismo momento que era acusada de haber realizado fraude de más de 11 millones de vehículos, su página web recogía que era líder en los ratings más relevantes de RSC o participando activamente en el PMNU. Desgraciadamente este caso no es aislado…
Diferencias entre empresas familiares y no familiares: mediación y moderación entre prácticas de recursos humanos y desempeño organizativo
2018
Dado que las empresas familiares son la mayoría, y que en Colombia existen pocos estudios empíricos en el tema, esta investigación pretende evaluar el impacto de las prácticas de recursos humanos en el desempeño organizativo, a través del efecto mediador de la innovación y el aprendizaje organizativo en empresas familiares vs no familiares. En el modelo se incluyen tres variables moderadoras; orientación emprendedora, orientación al mercado y turbulencia del entorno. A través de ecuaciones estructurales y con una muestra de 138 encuestas válidas, se obtiene que las relaciones evaluadas cambian entre empresas familiares y no familiares; las prácticas de recursos humanos impactan positivament…
De novo CCND2 mutations leading to stabilization of cyclin D2 cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome
2014
Activating mutations in genes encoding phosphatidylinositol 3-kinase (PI3K)-AKT pathway components cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome (MPPH, OMIM 603387)(1-3). Here we report that individuals with MPPH lacking upstream PI3K-AKT pathway mutations carry de novo mutations in CCND2 (encoding cyclin D2) that are clustered around a residue that can be phosphorylated by glycogen synthase kinase 313 (GSK-3 beta)(4). Mutant CCND2 was resistant to proteasomal degradation in vitro compared to wild-type CCND2. The PI3K-AKT pathway modulates GSK-3 beta activity(4), and cells from individuals with PIK3CA, PIK3R2 or AKT3 mutations showed similar CCND2 accumulation. CCND…
A mutation in the second intracellular loop of the pituitary adenylate cyclase activating polypeptide type I receptor confers constitutive receptor a…
2000
AbstractThe pituitary adenylate cyclase activating polypeptide (PACAP) type I receptor belongs to the glucagon/secretin/vasoactive intestinal polypeptide (VIP) receptor family. We mutated and deleted an amino acid residue (E261) which is located within the second intracellular loop of the rat PACAP type I receptor and which is highly conserved among the receptor family. The wild-type receptor and the mutant receptors were efficiently expressed at the surface of COS-7 cells at nearly the same level and revealed the same high affinity for the agonist PACAP-27. The cAMP contents of COS cells transfected with the E261A, E261Q, and the deletion mutant receptor were 4.6-, 5.7-, and 6.7-fold highe…
Immunohistochemical localization of the pro-peptide processing enzymes PC1/PC3 and PC2 in the human anal canal.
1997
Abstract HORsch, D., R. Day, N. G. Seidah, E. Weihe and M. K.-H. SchAFer. Immunohistochemical localization of the pro-peptide processing enzymes PC1/PC3 and PC2 in the human anal canal. Peptides 18(5) 755–760, 1997.—The distribution of prohormone/pro-peptide convertases PC1/PC3 and PC2 was investigated in the human anal canal by immunohistochemistry. Both prohormone convertases exhibited region-specific distribution patterns and were observed in neural and neuroendocrine cells and in nonneuroendocrine cellular elements. PC1/PC3 immunoreactivity was present in enteric neurons, subsets of nerve fibers, and neuroendocrine cells, and also in epithelial cells like intestinal stem cells, and a su…
Extensive nuclear gyration and pervasive non-genic transcription during primordial germ cell development in zebrafish.
2020
ABSTRACT Primordial germ cells (PGCs) are the precursors of germ cells, which migrate to the genital ridge during early development. Relatively little is known about PGCs after their migration. We studied this post-migratory stage using microscopy and sequencing techniques, and found that many PGC-specific genes, including genes known to induce PGC fate in the mouse, are only activated several days after migration. At this same time point, PGC nuclei become extremely gyrated, displaying general broad opening of chromatin and high levels of intergenic transcription. This is accompanied by changes in nuage morphology, expression of large loci (PGC-expressed non-coding RNA loci, PERLs) that ar…
Trade-off Performance of Optical Nanoantennas for Solar Energy Harvesting Applications
2019
In this paper, the optimum behaviour of optical nanoantennas, in terms of impedance, directivity, available power, and field enhancement, at a resonance frequency of about 350 THz, will be shown. Optimum configurations are obtained by varying nanoantennas geometry in order to maximize the available power, enhancing the electric field in gap proximity and so the absorptivity. Moreover, the simulation results for aluminum nanoantennas on a three-layers substrate, will be reported, and a trade-off performance comparison among different antennas will be discussed. This study can guide both the engineering and the fabrication of plasmonic nanoantennas.
Clustering and interorganizational dynamics in foreign market entry strategies. Evidence from Chinese MNEs
2015
Owing to the globalization and economic integration worldwide, countries and markets become more independent, and companies and people are all inevitably involved in the global marketplace. This situation increases the importance of international management (IM) in nowadays business practice and the relevance of study on it. The essential focus of IM research is on multinational enterprise (MNE) strategies, among which the foreign market entry strategies have been underlined and received a great deal of attention. The carried out research aims to increase the knowledge on MNE’s behaviors and strategic decisions in foreign direct investment (FDI). We first gave a retrospective look at foreig…
Prefazione
2020
nel contributo l'autore introduce il tema della tutela dei diritti nell'esecuzione forzata. Con riferimento all'espropriazione forzata osserva come, a seguito delle riforme degli ultimi anni, sia stato eroso il principio tradizionale della par condicio creditorum. Con riferimento all'esecuzione c.d. diretta introduce e illustra alcuni aspetti problematici in ordine alla tutela, specie con riferimento ai diritti obbligatori.