Search results for "dire"
showing 10 items of 3084 documents
GW170817: Observation of Gravitational Waves from a Binary Neutron Star Inspiral
2017
On August 17, 2017 at 12-41:04 UTC the Advanced LIGO and Advanced Virgo gravitational-wave detectors made their first observation of a binary neutron star inspiral. The signal, GW170817, was detected with a combined signal-to-noise ratio of 32.4 and a false-alarm-rate estimate of less than one per 8.0×104 years. We infer the component masses of the binary to be between 0.86 and 2.26 M, in agreement with masses of known neutron stars. Restricting the component spins to the range inferred in binary neutron stars, we find the component masses to be in the range 1.17-1.60 M, with the total mass of the system 2.74-0.01+0.04M. The source was localized within a sky region of 28 deg2 (90% probabili…
Binding abilities of polyaminocyclodextrins: polarimetric investigations and biological assays.
2017
Three polyaminocyclodextrin materials, obtained by direct reaction between heptakis(6-deoxy-6-iodo)-β-cyclodextrin and the proper linear polyamines, were investigated for their binding properties, in order to assess their potential applications in biological systems, such as vectors for simultaneous drug and gene cellular uptake or alternatively for the protection of macromolecules. In particular, we exploited polarimetry to test their interaction with some model p-nitroaniline derivatives, chosen as probe guests. The data obtained indicate that binding inside the host cavity is mainly affected by interplay between Coulomb interactions and conformational restraints. Moreover, simultaneous i…
Diskriminācijas aizliegums invaliditātes dēļ nodarbinātības jomā
2018
Tēma „Diskriminācija invaliditātes dēļ nodarbinātības jomā” ir aktuāla, jo Eiropas Savienības tiesa jēdzienu „invaliditāte” Direktīvas 2000/78/EK izpratnē ir definējusi tikai savos spriedumos, ņemot vērā Apvienoto Nāciju organizācijas Konvenciju par personu ar invaliditātes tiesībām, tāpēc tas regulāri attīstās. Darbā ir apskatīts invaliditātes jēdziens un diskriminācijas pārkāpuma lietas Eiropas Savienības tiesībās, invaliditātes jēdziena izpratne Latvijā, jēdzienu „slimība” un „invaliditāte” savstarpēja nošķiršana Eiropas Savienībā un Latvijā. Autore secina, ka Latvijai ir nepieciešams paplašināt Invaliditātes likumā definēto invaliditātes jēdzienu atbilstoši Direktīvai 2000/78/EK un Apvi…
Consumo de alimentos funcionales: factores determinantes
2019
El concepto de alimento funcional nació en Japón en 1991, y desde entonces ha sido objeto de estudio debido al gran crecimiento de mercado que ha experimentado esta categoría de producto en las últimas décadas (Arai, Osawa, Ohigashi, Yoshikawa, Kaminogawa, Watanabe, . . . Nishino, 2001). En líneas generales, podemos definir que un alimento se considera funcional si se demuestra que ejerce un efecto beneficioso sobre una o más funciones selectivas del organismo, además de sus efectos nutritivos intrínsecos, de modo que mejore el estado de salud y bienestar, reduzca el riesgo de enfermedad, o ambas cosas (Diplock, Agget,Ashwell, Bornet, Fern y Roberfroid, 1999). Ahora bien, el consumidor s…
Brain Modulation by Electric Currents in Fibromyalgia: A Structured Review on Non-invasive Approach With Transcranial Electrical Stimulation
2018
Fibromyalgia syndrome (FMS) is a complex disorder where widespread musculoskeletal pain is associated with many heterogenous symptoms ranging from affective disturbances to cognitive dysfunction and central fatigue. FMS is currently underdiagnosed and often very poorly responsive to pharmacological treatment. Pathophysiology of the disease remains still obscure even if in the last years fine structural and functional cerebral abnormalities have been identified, principally by neurophysiological and imaging studies delineating disfunctions in pain perception, processing and control systems. On such basis, recently, neurostimulation of brain areas involved in mechanism of pain processing and …
Effects of tDCS on Bimanual Motor Skills: A Brief Review.
2018
Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that allows the modulation of cortical excitability as well as neuroplastic reorganization using a weak constant current applied through the skull on the cerebral cortex. TDCS has been found to improve motor performance in general and motor learning in particular. However, these effects have been reported almost exclusively for unimanual motor tasks such as serial reaction time tasks, adaptation tasks, or visuo-motor tracking. Despite the importance of bimanual actions in most activities of daily living, only few studies have investigated the effects of tDCS on bimanual motor skills. The objectives …
Modulation of Human Motor Cortical Excitability and Plasticity by Opuntia Ficus Indica Fruit Consumption: Evidence from a Preliminary Study through N…
2022
Indicaxanthin (IX) from Opuntia Ficus Indica (OFI) has been shown to exert numerous biological effects both in vitro and in vivo, such as antioxidant, anti-inflammatory, neuro-modulatory activity in rodent models. Our goal was to investigate the eventual neuro-active role of orally assumed fruits containing high levels of IX at nutritionally-relevant amounts in healthy subjects, exploring cortical excitability and plasticity in the human motor cortex (M1). To this purpose, we applied paired-pulse transcranial magnetic stimulation and anodal transcranial direct current stimulation (a-tDCS) in basal conditions and followed the consumption of yellow cactus pear fruits containing IX or white ca…
Effects of tDCS on Bimanual Motor Skills: A Brief Review
2018
Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that allows the modulation of cortical excitability as well as neuroplastic reorganization using a weak constant current applied through the skull on the cerebral cortex. TDCS has been found to improve motor performance in general and motor learning in particular. However, these effects have been reported almost exclusively for unimanual motor tasks such as serial reaction time tasks, adaptation tasks, or visuo-motor tracking. Despite the importance of bimanual actions in most activities of daily living, only few studies have investigated the effects of tDCS on bimanual motor skills. The objectives …
Wiener-Granger Causality in Network Physiology with Applications to Cardiovascular Control and Neuroscience
2016
Since the operative definition given by C. W. J. Granger of an idea expressed by N. Wiener, the Wiener–Granger causality (WGC) has been one of the most relevant concepts exploited by modern time series analysis. Indeed, in networks formed by multiple components, working according to the notion of segregation and interacting with each other according to the principle of integration, inferring causality has opened a window on the effective connectivity of the network and has linked experimental evidences to functions and mechanisms. This tutorial reviews predictability improvement, information-based and frequency domain methods for inferring WGC among physiological processes from multivariate…
Recenti tendenze in tema di responsabilità degli intermediari di Internet nella tradizione giuridica occidentale
2019
Il saggio prende in esame il dibattito circa la necessità di modificare gli attuali regimi di irresponsabilità degli intermediari della rete, dibattito in corso nelle esperienze statunitense ed unitaria europea. Con riferimento all’esperienza statunitense, non è chiaro, infatti, se il ricorso sempre più frequente alla procedura di notice and take down sia sintomo del successo del sistema di notice based liability, congegnato dal legislatore federale nel 1998 o sia, al contrario, espressione del suo fallimento. In tale ottica, al fine di verificare la possibilità di transitare da un sistema di notice and take down ad un sistema di notice and stay down, il saggio prende in esame le recenti in…