Search results for "dorsal root ganglion"
showing 9 items of 19 documents
Distribution of origin of nitric oxide synthase-immunoreactive nerve fibers in the rat epididymis.
1996
Abstract Distribution of neuronal nitric oxide synthase-immunoreactive (nNOS-IR) nerve fibers and somata in the rat epididymis and major pelvic ganglia was studied by immunohistochemical methods. In the epididymis, the supply of nNOS-IR fibers was highest in the cauda and became progressively fewer toward the caput. In the cauda and corpus, nNOS-IR fibers were distributed throughout the subepithelial tissues and around the epithelium. The pattern of distribution of vasoactive intestinal polypeptide (VIP)- and tyrosine hydroxylase (TH)-immunoreactive fibers in the epididymis was similar but the latter was generally more numerous in a given region as compared to that of nNOS-IR fibers. A popu…
Nitric oxide synthase-immunoreactive vagal afferent fibers in rat superior cervical ganglia
1995
Abstract Chronic (5–14 days) preganglionic denervation of the rat superior cervical ganglia by sectioning the cervical sympathetic trunk resulted in a time-related partial or complete loss of nitric oxide synthase (isoform I)-immunoreactive fibers and terminals surrounding many sympathetic ganglionic neurons. Unexpectedly, denervation unmasked many varicose nitric oxide synthase-immunoreactive fibers, some of which could be traced the entire length of the superior cervical ganglia. Injection of the retrograde tracer Fluorogold into the superior cervical ganglia labeled a population of nodose ganglion cells and of dorsal root ganglion cells from C8 to T3 segments. When the same sections were…
Interleukin-6 (IL-6) and its soluble receptor support survival of sensory neurons
1999
The cytokine interleukin-6 (IL-6) has multiple functions in the immune and hematopoietic systems. IL-6 is related to ciliary neurotrophic factor (CNTF), a trophic factor for motoneurons, sensory dorsal root ganglion (DRG) neurons, and other neuronal subpopulations. Both act via related receptor complexes, consisting of one ligand-specific α-receptor subunit (IL-6R and CNTFR, respectively) and two signal-transducing receptor components. Even though IL-6 is expressed by neurons and glia, the functions of IL-6 in the nervous system are poorly understood. Here, we report that exogenous human IL-6 promotes the survival of dissociated newborn rat DRG neurons in vitro if supplemented with soluble …
Engineered axon tracts within tubular biohybrid scaffolds
2021
[EN] Injuries to the nervous system that involve the disruption of axonal pathways are devastating to the individual and require specific tissue engineering strategies. Here we analyse a cells-biomaterials strategy to overcome the obstacles limiting axon regeneration in vivo, based on the combination of a hyaluronic acid (HA) single-channel tubular conduit filled with poly-L-lactide acid (PLA) fibres in its lumen, with pre-cultured Schwann cells (SCs) as cells supportive of axon extension. The HA conduit and PLA fibres sustain the proliferation of SC, which enhance axon growth acting as a feeder layer and growth factor pumps. The parallel unidirectional ensemble formed by PLA fibres and SC …
Co-expression of heat sensitive vanilloid receptor subtypes in rat dorsal root ganglion neurons
2003
Expression of the heat sensitive cation channels TRPV1 and TRPV2 was investigated by immunofluorescence in rat dorsal root ganglion (DRG) neurons. TRPV1-positive neurons were more frequent and had smaller diameters than TRPV2-positive neurons (35.7% vs 7.3%; 22.3 microm vs 27.6 microm), but size distributions overlapped and significant co-expression was seen in 20.7% of TRPV2-positive neurons (1.7% of all). Expression patterns did not differ between tissue sections typically used in immunocytochemistry and dissociated DRG neurons typically used in electrophysiology. Rectangular temperature pulses revealed two patterns of heat-evoked inward currents in small DRG neurons: low-threshold rapidl…
Neuropeptides in Primary Afferent Neurons
1990
Traditionally, the primary sensory neurons, having their perikarya in the spinal or cranial sensory ganglia with processes directed towards the periphery and the central nervous system, have been regarded to function as receptive and afferent systems which reflexly activate central effector systems.1 This, however, does not apply to the small diameter primary afferents as suggested by the observation made about a century ago that antidromic stimulation of transected dorsal roots or sensory nerves caused vasodilatation and inflammatory signs in the skin.2,3 The novel concept which has been confirmed by many investigators ascribes to small diameter (particularly unmyelinated C) primary sensor…
Electrocatheter-mediated High-voltage Pulsed Radiofrequency of the Dorsal Root Ganglion in the Treatment of Chronic Lumbosacral Neuropathic Pain
2019
Objectives:Despite the interest in scientific community, there is still poor evidence about pulsed radiofrequency (PRF) efficacy in the treatment of neuropathic pain. In order to determine whether high-voltage PRF and epidural adhesiolysis (PRF-EA) showed better results than epidural adhesiolysis al
Nerve Root and Types of Needles Used in Transforaminal Injections
2014
The use of transforaminal epidural injections of steroids is common practice in pain medicine, in patients with radicular pain resistant to conventional treatments such as physiotherapy or anti-inflammatory medications. The goal of these injections is to deposit steroids in the proximity of nerve roots, using the epidural or the transforaminal route. The procedure is performed using a translaminar, caudal, or transforaminal approach.
Interventional treatment for neuropathic pain due to combined cervical radiculopathy and carpal tunnel syndrome: a case report
2017
Key Clinical Message The coexistence of median and cervical nerve root damage might hide a complex pathophysiology. Here, we describe and discuss the case of a patient suffering from numbness and painful tingling of the hand, whose symptoms were effectively treated with pulsed radiofrequency and epidural administration of bupivacaine and morphine.