Search results for "dosing"

Verlängerte Sekundärprophylaxe nach venöser Thromboembolie

2018

Was ist neu? Aktuelle Studien Kurz nach Absetzen der oralen Antikoagulation kommt es zu einem etwa 2- bis 3-fachen Anstieg von VTE-Rezidiven. Das Rezidivrisiko ist besonders hoch nach einer VTE, die ohne identifizierbaren Auslöser aufgetreten war oder wenn nur weiche, unsichere auslösende Risikofaktoren vorlagen, sowie bei fortbestehenden Risikofaktoren, wie z. B. einer Krebserkrankung. Konsensusdokument über auslösende Risikofaktoren für venöse Thromboembolie In einem aktuellen Konsensusdokument wurden die zugrundeliegenden Risikofaktoren definiert und in 3 Gruppen klassifiziert. Direkte orale Antikoagulanzien Eine reduzierte Dosis von DOAK ermöglicht eine wirksame verlängerte Sekundärprop…

Risks Associated with the Use of Garcinia as a Nutritional Complement to Lose Weight

2021

Nowadays, obesity is one of the great nutritional problems facing public health. The prevalence of this pathology has increased in a worrying way over recent years, currently reaching epidemic proportions. In this context, nutritional supplements are presented as a therapeutic alternative to which more and more people are turning to. Nutritional supplements to lose weight based on the Garcinia plant, specifically on Garcinia cambogia, are commonly used. The active principle of this plant to which these properties have been attributed, is hydroxycitric acid (HCA). The aim of the present review is to gather reported data concerning the effectiveness of nutritional supplements based on Garcini…

Influence of ferric iron dosing on aerobic granular sludge: granule formation, nutrient removal and microbial community

2021

BACKGROUND: Three lab-scale sequencing batch reactors were used to investigate the effects of Fe3+ on aerobic granular sludge (AGS) formation, nutrient removal, and microbial community. RESULTS: The addition of 6 and 12 mg Fe3+ L−1 could not shorten the granulation time. However, compared to the reactor without Fe3+ addition (average sludge volume index at 30 min (SVI30) 70.8 mL g−1; stable average particle size 548 μm), the addition of 12 mg Fe3+ L−1 helped improve the physical properties of AGS (average SVI30 57.0 mL g−1; stable average particle size 1067 μm). Furthermore, with 12 mg Fe3+ L−1 addition (Fe3+ to PO43−-P molar ratio = 1.33), effective removal of NH4+-N (≤0.5 mg L−1) and PO43…

Topiramate pharmacokinetics in neonates undergoing therapeutic hypothermia and proposal of an optimised dosing schedule.

2019

Aim The adequate dosing of topiramate in neonates undergoing therapeutic hypothermia has not been established. The aim of this study was to design a dosing schedule capable of providing topiramate serum concentrations within the accepted therapeutic range. Methods Neonates (n = 52) with hypoxic ischaemic encephalopathy and subjected to therapeutic hypothermia were dosed with topiramate, 5 mg/kg on day one and 3 mg/kg on days two to five, to decrease seizure events. A total of 451 topiramate serum concentrations obtained in the patients were used to develop a population pharmacokinetic model using a non-linear mixed-effects modelling approach. Results A one-compartment model with first-order…

208: Impact of posaconazole (POS) vs fluconazole (FLU) on cyclosporine (CsA) and tacrolimus (TAC) dosing in hematopoietic stem cell transplant (HSCT)…

2007

C1-Esterase Inhibitor Concentrate for Acute Laryngeal Hereditary Angioedema (HAE) Attacks: Different Treatment Response Based on Dosing Regimen?

2016

Takrolimus w długoterminowym leczeniu immunosupresyjnym biorców przeszczepu nerki — praktyczne wskazówki

2020

Tacrolimus got the position crucial immunosuppressive drug in a solid organ transplantation. For obtaining the best long-term results it is essential an avoidance of excessive dose lowering and maintenance stable drug concentration. The intrapatient tacrolimus concentration variability, which exerts negative impact on the graft survival, should be differentiated from fluctuation, describing distinct pharmacokinetic event, without proven clinical significance. Furthermore, real tacrolimus concentration variability should be separated from variability caused by recipient instability. Among causes of tacrolimus intrapatient variability on the first places are: insufficient adherence to treatme…

C1-Esterase Inhibitor Concentrate For Acute Attacks Of Laryngeal Edema In Hereditary Angioedema (HAE): Fixed Dosing Vs Body Weight-Adjusted Dosing

2014

Rapid onset opioids for breakthrough pain: Titrating or not titrating, this is the question!

2011

Abstract Breakthrough cancer pain (BTcP) has been defined as a transitory increase in pain intensity that occurs either spontaneously, or in relation to a specific predictable or unpredictable trigger, despite relatively stable and adequately controlled background pain. Traditional dosing recommendations for BTcP have suggested that the effective dose of oral opioids should be a percentage of a patient’s total daily opioid dose. In the last years a number of new formulations that deliver fentanyl directly through mucous membranes have been developed in an effort to provide a more rapid onset of effect (rapid onset opioids, ROOs). Recent recommendations suggest that the dose of ROOs for BTcP…

The use of rapid onset opioids for breakthrough cancer pain: the challenge of its dosing.

2011

Breakthrough cancer pain (BTcP) has been defined as a transitory increase in pain intensity on a baseline pain of moderate intensity in patients on analgesic treatment regularly administered. This review provides updated information about the use of opioids for the treatment of BTcP, with special emphasis on the use of new rapid onset opioids (ROOs). Due to its slow onset to effect oral opioids cannot be considered an efficacious treatment for BTcP. Parenteral opioids may provide rapid onset of analgesia, but not always available particularly at home. Different technologies have been developed to provide fast pain relief with potent opioid drugs such fentanyl, delivered by non-invasive rout…