Search results for "droni."

High-pt particle production, correlations, and observables sensitive to energy loss in small (and large) collision systems

2023

Measurement of the Fluctuations in the Number of Muons in Extensive Air Showers with the Pierre Auger Observatory

2021

The successful installation, commissioning, and operation of the Pierre Auger Observatory would not have been possible without the strong commitment and effort from the technical and administrative staff in Malargue. We are very grateful to the following agencies and organizations for financial support: Argentina-Comision Nacional de Energia Atomica, Agencia Nacional de Promocion Cientifica y Tecnologica (ANPCyT), Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Gobierno de la Provincia de Mendoza, Municipalidad de Malargue, NDM Holdings and Valle Las Lenas; in gratitude for their continuing cooperation over land access; Australia-the Australian Research Council; Brazil…

Success and challenges of flow harmonic analysis in LHC collisions from large to small systems

2022

One of the primary goals of heavy-ion physics is to understand the transport properties of the quark-gluon-plasma (QGP) which comprises the tiniest constituents, quarks and gluons, that prevailed in the first few microseconds after the Big Bang. The present most challenging part of the research is pinning down the critical point of the QGP, where the shear viscosity over entropy ratio (η/s) is at its minimum and very close to the lowest value in nature 1/(4π). Significant advances based on flow harmonic analysis have been made up to date. However, there are still few remaining challenges in experiments and theory to constrain the temperature dependence of η/s and ζ/s of the QGP. In this tal…

New Constraints of QCD Matter from Bayesian Parameter Estimation with LHC Data

2022

New constraints of QCD matter from improved Bayesian parameter estimation with the latest LHC data

2022

Transport properties of the matter created in heavy-ion collisions, the quark-gluon plasma (QGP), contain essential information about quantum chromodynamics (QCD). In this talk, we present our latest study in inferring the transport properties of QGP by an improved Bayesian analysis using the CERN Large Hadron Collider Pb-Pb data. The uncertainties of the extracted properties are reduced by adding new observables sensitive to specific shear and bulk viscosity, reflecting mostly nonlinear hydrodynamic responses. The analysis also reveals that higher-order harmonic flows and their correlations have a higher sensitivity to the transport properties than other observables. This observation shows…

Bone targeting compounds for radiotherapy and imaging: *Me(III)-DOTA conjugates of bisphosphonic acid, pamidronic acid and zoledronic acid

2016

Background Bisphosphonates have a high adsorption on calcified tissues and are commonly used in the treatment of bone disorder diseases. Conjugates of bisphosphonates with macrocyclic chelators open new possibilities in bone targeted radionuclide imaging and therapy. Subsequent to positron emission tomography (PET) examinations utilizing 68Ga-labelled analogues, endoradiotheraphy with 177Lu-labelled macrocyclic bisphosphonates may have a great potential in the treatment of painful skeletal metastases. Methods Based on the established pharmaceuticals pamidronate and zoledronate two new DOTA-α-OH-bisphosphonates, DOTAPAM and DOTAZOL(MM1.MZ) were successfully synthesized. The ligands were labe…

Evaluation of the inverse electron demand Diels-Alder reaction in rats using a scandium-44-labelled tetrazine for pretargeted PET imaging

2019

Background Pretargeted imaging allows the use of short-lived radionuclides when imaging the accumulation of slow clearing targeting agents such as antibodies. The biotin-(strept)avidin and the bispecific antibody-hapten interactions have been applied in clinical pretargeting studies; unfortunately, these systems led to immunogenic responses in patients. The inverse electron demand Diels-Alder (IEDDA) reaction between a radiolabelled tetrazine (Tz) and a trans-cyclooctene (TCO)-functionalized targeting vector is a promising alternative for clinical pretargeted imaging due to its fast reaction kinetics. This strategy was first applied in nuclear medicine using an 111In-labelled Tz to image TC…

Lidaparātu trajektoriju konstruēšana balstoties uz Bezjē līknēm

2015

Pēdējos gados ļoti strauji attīstās tāda robotikas nozare, kā visu veidu lidojošie droni: kvadro- kopteri, oktakoperi u.t.t. Tehnoloģiju attīstības dēļ palika reāla autonomo dronu realizācija un sāka parādīties daži veidi, kā izmantot dronus. Darbā tiek izstrādāts autonomā kvadrokoptera trajektorijas konstruēšanas algoritms, balstoties uz Bezjē līknēm. Tiek apskatīts iepriekš izman- totais algoritms, tā trūkumi un priekšrocības. Izstrādātais algoritms tika implementēts Latvijas izstrādātajā dronā ”AirDog” un salīdzināti vecā un jaunā algoritma darbības rezultāti dažādos apstākļos.

Analysis of molecular mechanisms and anti-tumoural effects of zoledronic acid in breast cancer cells

2012

Zoledronic acid (ZOL) is the most potent nitrogen-containing bisphosphonate (N-BPs) that strongly binds to bone mineral and acts as a powerful inhibitor of bone resorption, already clinically available for the treatment of patients with osteolytic metastases. Recent data also suggest that ZOL, used in breast cancer, may provide more than just supportive care modifying the course of the disease, though the possible molecular mechanism of action is still unclear. As breast cancer is one of the primary tumours with high propensity to metastasize to the bone, we investigated, for the first time, differential gene expression profile on Michigan Cancer Foundation-7 (MCF-7) breast cancer cells tre…

Improving adherence in osteoporosis: a new management algorithm for the patient with osteoporosis

2011

Introduction: Bisphosphonates are the first-choice treatment for osteoporosis. They effectively increase bone mineral density, reduce markers of bone resorption, and lower the incidence of new fractures in patients with osteoporosis-related fracture. However, the efficacy observed in clinical trials may not be realized in a real-life setting, partly due to poor adherence to therapy, with a significant worsening of clinical outcomes. Several issues contribute to poor adherence to osteoporosis medication, including inconvenient dosing regimens and concerns about possible adverse events. Although strategies to improve adherence have been investigated, new approaches are required. Areas covered…