Search results for "drug delivery."

showing 10 items of 692 documents

Transcutol containing vesicles for topical delivery of minoxidil

2010

The aim of this work was to evaluate the ability of Transcutol (Trc) to produce elastic vesicles with soy lecithin (SL) and study the influence of the obtained vesicles on in vitro (trans)dermal delivery of minoxidil. To this purpose, so-called penetration enhancer-containing vesicles (PEVs) were prepared using Trc aqueous solutions (5-10-20-30% v/v) as hydrophilic phase. SL liposomes, without Trc, were used as control. Prepared formulations were characterized in terms of size distribution, morphology, zeta potential, deformability, and rheological behavior. The influence of the obtained PEVs on (trans)dermal delivery of minoxidil was studied by in vitro diffusion experiments through pig sk…

SwineStereochemistryVasodilator AgentsPharmaceutical ScienceAdministration CutaneousDiffusionExcipientschemistry.chemical_compoundDrug Delivery SystemsDrug Stabilitystomatognathic systemPhosphatidylcholineLecithinsZeta potentialmedicineAnimalsParticle SizeMicroparticleSkinDrug CarriersLiposomeAqueous solutionChromatographyChemistryVesiclefungiPenetration (firestop)MinoxidilLiposomesMinoxidilEthylene Glycolsmedicine.drugJournal of Drug Targeting
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Sorbitol-penetration enhancer containing vesicles loaded with baicalin for the protection and regeneration of skin injured by oxidative stress and UV…

2018

Abstract Aiming at improving the protective effects of baicalin on the skin, new highly-biocompatible penetration enhancer containing vesicles (PEVs) were developed by modifying the base formulation of transfersomes with sorbitol, thus obtaining sorbitol-PEVs. An extensive evaluation of the physico-chemical features of both transfersomes and sorbitol-PEVs was carried out. Transfersomes were mainly close-packed, multi-compartment vesicles, while sorbitol-PEVs appeared mostly as single, spherical, unilamellar vesicles. All the vesicles were small in size (∼128 nm) and negatively charged (∼−67 mV), without significant differences between the formulations. The in vitro delivery of baicalin to i…

SwineUltraviolet RaysChemistry PharmaceuticalCellPharmaceutical Science02 engineering and technologymedicine.disease_cause030226 pharmacology & pharmacyCell LineExcipients03 medical and health scienceschemistry.chemical_compoundMice0302 clinical medicineDrug Delivery SystemsCell MovementmedicineAnimalsHumansRegenerationSorbitolParticle SizeCell ProliferationSkinFlavonoidsWound HealingCell growthVesicleRegeneration (biology)fungi3T3 Cells021001 nanoscience & nanotechnologyIn vitroOxidative Stressmedicine.anatomical_structurechemistryBiophysicsSorbitol0210 nano-technologyBaicalinOxidative stressInternational journal of pharmaceutics
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Azobenzene Polyesters Used as Gate-Like Scaffolds in Nanoscopic Hybrid Systems

2012

The synthesis and characterisation of new capped silica mesoporous nanoparticles for on-command delivery applications is reported. Functional capped hybrid systems consist of MCM-41 nanoparticles functionalised on the external surface with polyesters bearing azobenzene derivatives and rhodamine¿B inside the mesopores. Two solid materials, Rh-PAzo8-S and Rh-PAzo6-S, containing two closely related polymers, PAzo8 and PAzo6, in the pore outlets have been prepared. Materials Rh-PAzo8-S and Rh-PAzo6-S showed an almost zero release in water due to steric hindrance imposed by the presence of anchored bulky polyesters, whereas a large delivery of the cargo was observed in the presence of an esteras…

TECNOLOGIA DE ALIMENTOSazo compoundsPolyestersenzymesNanoparticlemesoporous materialspolyestersCatalysischemistry.chemical_compoundDrug Delivery SystemsQUIMICA ORGANICAPolymer chemistryHumanschemistry.chemical_classificationOrganic ChemistryQUIMICA INORGANICAGeneral ChemistryPolymerMesoporous silicaHydrogen-Ion ConcentrationSilicon DioxideControlled releaseMesoporous materialsEnzymesPolyesterAzobenzenechemistryChemical engineeringDrug deliveryDrug deliverydrug deliveryNanoparticlesCamptothecinMesoporous materialAzo CompoundsPorosityHeLa Cells
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Uptake of poly(2-hydroxypropylmethacrylamide)-coated gold nanoparticles in microvascular endothelial cells and transport across the blood-brain barri…

2020

The facile and modular functionalization of gold nanoparticles makes them versatile tools in nanomedicine, for instance, photothermal therapy, contrast agents or as model nanoparticles to probe drug-delivery mechanisms. Since endothelial cells from various locations in the body exhibit unique phenotypes we quantitatively examined the amount of different sized poly(2-hydroxypropylmethacrylamide)-coated gold nanoparticles internalized into primary human dermal endothelial cells or human brain endothelial cells (hCMEC/D3) by inductively coupled plasma atomic emission spectroscopy (ICP-AES) and visualized the nanoparticles using light and electron microscopy. Poly(2-hydroxypropylmethacrylamide)…

TPChemistryBiomedical EngineeringDrug delivery to the brainNanoparticleProtein CoronaNanotechnologyPhotothermal therapyBlood–brain barrierQPR1medicine.anatomical_structureColloidal goldDrug deliverymedicineBiophysicsNanomedicineGeneral Materials ScienceBiomaterials science
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THERAPEUTIC-LOADED LIPID NANOSTRUCTURES AND BRAIN DISEASES.

2012

Central Nervous System (CNS) diseases represent the largest and fastest growing area of unmet medical need since an alarming increase in brain disease incidence is going on. Despite major advances in neuroscience, many potential therapeutic agents are denied access to the CNS because of the existence of a physiological low permeable barrier, the Blood-Brain Barrier (BBB). To obtain an improvement of drug CNS performance, sophisticated approaches such as nanoparticulate systems are rapidly developing. In particular, in this chapter, the most recent data demonstrating the potential of lipid nanostructures, such as Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid Carriers (NLC), to tra…

Targeted drug delivery systemsSettore CHIM/09 - Farmaceutico Tecnologico ApplicativoSolid lipid nanoparticleNanostructured lipid carrierBlood-brain barrier
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Rapid and eco-friendly synthesis of graphene oxide-silica nanohybrids

2014

The increasing interest in Graphene oxide (GO) is due to many issues: the presence of both sp2-conjugated atoms and oxygen-containing functional groups provides a strong hydrophilicity and the possibility to further functionalize it with other molecules (i.e. π-π interactions covalent attachment etc.) [1]. Furthermore since the GO is biocompatible and noncytotoxic many studies have been recently focused on the development of GO-based nanodevices for bioimaging DNA detection drug delivery. Due to their low cytotoxicity and large internal surface area silica nanoparticles have been taken into account as promising material for biolabeling and drug loading/delivery. Particular consideration has recently been demonstrated for GO-silica composites because of the potentialities for electrical applications their chemical inertia and stability toward ions exposure. The possibility to combine the extraordinary properties of GO and silica offers several advantages for the realization of nanoprobes for biological applications and of biosensor [12]. The strategy for the fabrication of GO-nanosilica nanohybrids can be schematized as follows: (i) synthesis of GO by oxidizing graphite powder with the method described by Marcano et al. [3] (ii) Preparation of oxygen-loaded silica nanoparticles by thermal treatments in controlled atmosphere in order to induce high NIR emission at 1272 nm from high purity silica nanoparticles. (iii) preparation of GrO-silica nanohybrid films via rapid solvent casting in water. The nanohybrids were tested by XPS FTIR Raman analysis UV photoluminescence analysis TGA Zeta potential measurements electrical tests AFM and SEM. Several nanohybrids were prepared by combining two different typologies of GO and two different samples of silica.
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Elaboration of Trans-Resveratrol Derivative-Loaded Superparamagnetic Iron Oxide Nanoparticles for Glioma Treatment

2019

In this work, new nanohybrids based on superparamagnetic iron oxide nanoparticles (SPIONs) were elaborated and discussed for the first time as nanovectors of a derivative molecule of trans-resveratrol (RSV), a natural antioxidant molecule, which can be useful for brain disease treatment. The derivative molecule was chemically synthesized (4&rsquo

Thermogravimetric analysisGeneral Chemical EngineeringNanoparticle02 engineering and technologyArticletrans-resveratrol derivativelcsh:Chemistry03 medical and health sciencesDynamic light scatteringX-ray photoelectron spectroscopygliomaZeta potentialMoleculeGeneral Materials Science[SPI.NANO]Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronics030304 developmental biologyiron oxide superparamagnetic nanoparticles0303 health sciencesChemistry<i>trans</i>-resveratrol derivativefood and beverages021001 nanoscience & nanotechnology3. Good healthMembranelcsh:QD1-999Drug deliverydrug delivery0210 nano-technologyNuclear chemistryNanomaterials
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PHEA-graft-polybutylmethacrylate copolymer microparticles for delivery of hydrophobic drugs.

2012

Abstract Polymeric microparticles encapsulating two model hydrophobic drugs, beclomethasone dipropionate (BDP) and flutamide (FLU) were prepared by using the high pressure homogenization-solvent evaporation method starting from a oil-in-water emulsion. For the preparation of polymeric microparticles a α,β-poly(N-2-hydroxyethyl)- d , l -aspartamide (PHEA) graft copolymer with comb like structure was properly synthesized via grafting from atom transfer radical polymerization (ATRP) technique, by using two subsequent synthetic steps. In the first step a polymeric multifunctional macroinitiator was obtained by the conjugation of a proper number of 2-bromoisobutyryl bromide (BIB) residues to the…

Time FactorsBioadhesivePharmaceutical ScienceCell LineDrug Delivery SystemsPolymethacrylic AcidsPolymer chemistryMucoadhesionCopolymerSide chainHumansPhea polybutylmethacrylate microparticles drug deliveryParticle SizeGlucocorticoidsDrug CarriersDose-Response Relationship DrugChemistryAtom-transfer radical-polymerizationBeclomethasoneAdhesivenessAndrogen AntagonistsGraftingFlutamideMicrospheresPolymerizationDelayed-Action PreparationsEmulsionSolventsNanoparticlesEmulsionsCaco-2 CellsPeptidesHydrophobic and Hydrophilic InteractionsInternational journal of pharmaceutics
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A new biodegradable and biocompatible hydrogel with polyaminoacid structure

2007

The preparation and physicochemical and biological characterization of a novel polyaminoacid hydrogel have been reported. The ,-poly(N-2- hydroxyethyl)-dl-aspartamide (PHEA) has been used as a starting polymer for a derivatization reaction with methacrylic anhydride (MA) to give rise to the methacrylate derivative named PHM. Photocrosslinking of PHM has been performed in aqueous solution at 313 nm and in the absence of toxic initiators. PHM-based hydrogel has been characterized by scanning electron microscopy, X-ray diffractometry, swelling measurements in aqueous media; the degradation of PHM-based hydrogel has been evaluated as a function of time in the absence or in the presence of ester…

Time FactorsBiocompatibilityCell SurvivalSurface PropertiesChemistry PharmaceuticalPharmaceutical ScienceMethacrylic anhydrideBiocompatible MaterialsMicroscopy Atomic ForceMethacrylateDosage formchemistry.chemical_compoundPolymethacrylic AcidsX-Ray DiffractionSpectroscopy Fourier Transform InfraredPolymer chemistryHumansTechnology PharmaceuticalDrug CarriersAqueous solutionHydrolysisEsterasestechnology industry and agricultureWaterHydrogelshydrogels FT-IRBlood ProteinschemistrySelf-healing hydrogelsDrug deliveryMicroscopy Electron ScanningK562 CellsPeptidesDrug carrierPorosityProtein BindingNuclear chemistryInternational Journal of Pharmaceutics
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Detoxifying antitumoral drugs via nanoconjugation: the case of gold nanoparticles and cisplatin

2021

Nanoparticles (NPs) have emerged as a potential tool to improve cancer treatment. Among the proposed uses in imaging and therapy, their use as a drug delivery scaffold has been extensively highlighted. However, there are still some controversial points which need a deeper understanding before clinical application can occur. Here the use of gold nanoparticles (AuNPs) to detoxify the antitumoral agent cisplatin, linked to a nanoparticle via a pH-sensitive coordination bond for endosomal release, is presented. The NP conjugate design has important effects on pharmacokinetics, conjugate evolution and biodistribution and results in an absence of observed toxicity. Besides, AuNPs present unique o…

Time FactorsCancer TreatmentMetal Nanoparticleslcsh:MedicinePharmacologyMiceNanotechnologyTissue Distributionlcsh:Sciencemedia_commonDrug DistributionDrug CarriersMultidisciplinaryChemistryDNA NeoplasmOrgan SizeHydrogen-Ion ConcentrationEndocytosisOncologyColloidal goldDrug deliveryInactivation MetabolicMedicinemedicine.drugResearch ArticleBiotechnologyDrugBiodistributionDrugs and Devicesmedia_common.quotation_subjectMaterials ScienceAntineoplastic AgentsMaterial by AttributePharmacokineticsCell Line TumormedicineAnimalsHumansPharmacokineticsBiologyNanomaterialsCisplatinUnited States Food and Drug Administrationlcsh:RChemotherapy and Drug TreatmentUnited StatesBionanotechnologylcsh:QGoldNanocarriersCisplatinConjugate
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