Search results for "drugs."

Morfina, alkohol, kokaina, czyli pomieszanie z poplątaniem w "Matce" Witkacego

2016

Tematem mojego artykułu jest problem używek przedstawiony w Matce Stanisława Ignacego Witkiewicza. Nadużywanie alkoholu i narkotyków, służące złagodzeniu bólu istnienia to - w kontekście omawianego utworu - zagłuszanie metafizycznych lęków nie tylko prezentowanych w nim postaci, ale także samego autora. Na przykładzie inscenizacji Jerzego Jarockiego z Teatru Starego w Krakowie opisuję złożoność relacji postaci, które dławiąc się własnym cierpieniem, popadają w nałogi. Zarówno dramat, jak i jego teatralna konkretyzacja stanowią laboratorium udręki wzajemnego bytowania, studium destrukcyjnej siły rodzinnych związków. Tutaj wszystko może się zdarzyć i na pewno będzie na „nie".

Nesteroīdo pretiekaisuma līdzekļu aprite aptiekā

2020

Nesteroīdie pretiekaisuma līdzekļi (NPL) ir vispieprasītākā medikamentu grupa pasaulē. Galvenie iemesli NPL lietošanai ir sāpes, iekaisums un drudzis. Darba mērķis bija salīdzināt NPL pieprasījumu par 2017., 2018. un 2019. gadu, kā arī noskaidrot, kādas ir biežākās blakusparādības, ar kurām šo medikamentu lietošanas laikā sastopas respondenti. Darba uzdevumi bija izanalizēt NPL apgrozījumu vienā no SIA “Euro aptieka” tīkla aptiekām, kura atrodas Rīgā, Ziepniekkalna rajonā par 2017., 2018. un 2019. gadu, noskaidrot, kuri NPL medikamenti ir vispieprasītākie, noskaidrot, kādas ir visbiežākās blakusparādības respondentiem, noskaidrot, kādas sāpes biežāk piemeklē respondentus. Iegūtie dati lieci…

Rescuing CFTR Protein Function: 1,3,4-oxadiazoles versus 1,2,4-oxadiazoles as readthrough inducing drugs

In Cystic fibrosis (CF) disease nonsense mutations in the CFTR gene cause the absence of the CFTR protein expression and a more severe form of the disease. About 10% of patient affected by CF show a nonsense mutation. A potential treatment of this alteration is to promote translational readthrough of premature termination codons (PTCs) by translational readthrough inducing drugs such as Ataluren (1). We reported a rationale for Ataluren promoted readthrough of PTCs by computational approach and GFP-reporter cell-based assay (2) and the observed enhancement of readthrough activity by some Ataluren derivatives (3, 4). In this context we aimed to compare the 1,2,4-oxadiazole core of Ataluren w…

Lipoprotein Subfractions in Metabolic Syndrome and Obesity: Clinical Significance and Therapeutic Approaches

2013

Small, dense low density lipoprotein (sdLDL) represents an emerging cardiovascular risk factor, since these particles can be associated with cardiovascular disease (CVD) independently of established risk factors, including plasma lipids. Obese subjects frequently have atherogenic dyslipidaemia, including elevated sdLDL levels, in addition to elevated triglycerides (TG), very low density lipoprotein (VLDL) and apolipoprotein-B, as well as decreased high density lipoprotein cholesterol (HDL-C) levels. Obesity-related co-morbidities, such as metabolic syndrome (MetS) are also characterized by dyslipidaemia. Therefore, agents that favourably modulate LDL subclasses may be of clinical value in t…

L’ASSIMILAZIONE IN AMBITO SPORTIVO DELLA SOMMINISTRAZIONE OFF-LABEL AL DOPING, SPUNTI GIURIDICI ED ETICI

2015

This paper offers an analysis about the issue of off-label drugs use in Italy, focusing on the sport area and on the role of the State. In particular interconnections and divergences with anti-doping regulation will be addressed, making some reflections about the partial lack of regulation.

Cyberzagrożenia rozwoju dzieci i młodzieży – podszeptywacze używek i podszeptywacze śmierci

2018

The article contains a description of two phenomena occurring in the network. The first phenomenon – online instiga-tors of suicides – concerns the phenomenon of manipulation of young Internet users, seeking support and listening to difficult situations by persuading them to commit suicide. The second phenomenon – online instigators of the drugs – concerns the phenomenon of drug education through drug addicts active in the network.

Methylprednisolone-induced hepatotoxicity in a 16-year-old girl with multiple sclerosis.

2018

Multiple sclerosis (MS) is a chronic inflammatory disease with demyelination of the central nervous system. High-dosage corticosteroids are the first-line therapy in the acute relapsing of MS. We report a case of severe high-dose methylprednisolone-induced acute hepatitis in a patient with a new diagnosis of MS. A 16-year-old girl was admitted for urticaria, angioedema, nausea and vomiting a month later she had been diagnosed with MS and treated with high-dosage methylprednisolone. Laboratory investigations showed hepatic insufficiency with grossly elevated liver enzymes. A liver biopsy showed focal centrilobular hepatocyte necrosis with interface hepatitis. Methylprednisolone-induced hepat…

Leki peptydowe przyszłością medycyny?

2022

To date, approximately 80 peptide drugs have been used practically. More than 150 peptides are in clinical development, and 400–600 peptides have been preclinically studied. Peptides act as hormones, growth factors, neurotransmitters, ion channel ligands, or antiinfective agents, therefore peptides are excellent candidates for drug discovery to complement medical treatment unmet by other types of medicines. For example, interfering peptides (IPs) have a high potential for modulation of protein-protein interaction (PPIs). Peptide drugs are used for bacterial and viral infections, problems with the circulatory system, diabetes, osteoporosis, appetite and hormone regulation, cancer, and many o…

Competition, Gender Equality, and Doping in Sports in the Red Queen Effect Perspective

2022

The nature of sports is characterized by a strong competitive component that generates inequalities among athletes at different levels, specifically in relation to gender, technology, and doping. These inequalities can be represented according to the Red Queen effect perspective, which has been previously hypothesized in other competitive environments (evolutionary biology and economics, for instance). The Red Queen effect considers each competitive environment to require a constant effort to maintain a position of competitive advantage in order reach the best result possible. Therefore, the aim of the current paper is to provide an innovative perspective for the understanding of competitio…

Pharmacomicrobiomics: Exploiting the Drug-Microbiota Interactions in Antihypertensive Treatment

2022

Hypertension is a leading risk factor for cardiovascular diseases and can reduce life expectancy. Owing to the widespread use of antihypertensive drugs, patients with hypertension have improved blood pressure control over the past few decades. However, for a considerable part of the population, these drugs still cannot significantly improve their symptoms. In order to explore the reasons behind, pharmacomicrobiomics provide unique insights into the drug treatment of hypertension by investigating the effect of bidirectional interaction between gut microbiota and antihypertensive drugs. This review discusses the relationship between antihypertensive drugs and the gut microbiome, including cha…