Search results for "dualization"

Modeling Human Endometrial Decidualization from the Interaction between Proteome and Secretome

2011

Context: Decidualization of the human endometrium, which involves morphological and biochemical modifications of the endometrial stromal cells (ESCs), is a prerequisite for adequate trophoblast invasion and placenta formation. Objective: This study aims to investigate the proteome and secretome of in vitro decidualized ESCs. These data were combined with published genomic information and integrated to model the human decidualization interactome. Design: Prospective experimental case–control study. Setting: A private research foundation. Patients: Sixteen healthy volunteer ovum donors. Intervention: Endometrial samples were obtained, and ESCs were isolated and decidualized in vitro. Main Ou…

El rol del modelo de las competencias en la reconfiguración meritocrática de las pautas de negociación salarial en empresas argentinas: continuidades…

2020

The development of new models of work organization and the complementary advance of flexible guidelines for the use of the labor force had as a correlate a profound change in techniques for the evaluation of workers. Thus, the typical model of Fordism, based on qualifications, was replaced by a different one based on competencies, whereby the strong relationship of the former was abandoned with the determination of the technical knowledge required for each job to move to a system which the priority is placed in the individual attitude. The consequent individualization of performance evaluations can lead to a possible loss of objectivity. In this article we develop a theoretical comparison b…

Special education students in transition to further education: A four-year register-based follow-up study in Finland

2016

Abstract This study examines the transition of special education students into upper secondary education in Finland. The national register-based school-level dataset comprises three compulsory school-leaving cohorts of 2004, 2006 and 2009 including all students and schools providing lower secondary education. Special education students (Tier 3) are divided into four different groups based on their curriculum adjustments. The school-level effect of special education provision is evaluated with statistical models exploiting the panel nature of the data. The results show that there are significant differences in participation in upper secondary education between the groups with different level…

Disrupted PGR-B and ESR1 signaling underlies preconceptional defective decidualization linked to severe preeclampsia

2021

AbstractDecidualization of the uterine mucosa drives the maternal adaptation to invasion by the placenta. Appropriate depth of placental invasion is needed to support a healthy pregnancy; shallow invasion is associated with the development of severe preeclampsia (sPE). Maternal contribution to sPE through failed decidualization is an important determinant of placental phenotype. However, the molecular mechanism underlaying the in vivo defect linking decidualization to sPE is unknown. Here, we discover the footprint encoding this decidualization defect comprising of 166 genes using global gene expression profiling in decidua from women who developed sPE in a previous pregnancy. This signatur…

Young Adults’ Conceptions of the Sacred in Finland Today

2016

This study examined young adults’ perspectives on the concept of the sacred. Altogether, 334 young Finnish adults aged 19–35 were studied through a self-report questionnaire. The participants’ personal conceptions, reflections and experiences of the sacred were assessed with open-ended questions. Answers were classified in a data-determined content analysis using a thematic analytical approach. In addition, the study examined how these understandings of the sacred were related to subjective religiosity and how the definitions vary across gender. The findings suggest that the conceptions of the sacred mainly concentrate on individuality and personal issues, including personal opinion, rest a…

P2-283: Dose individualization of Carboplatin in elderly patients with advanced non small cell lung cancer (ANSCLC): an exploratory analysis

2007

Proprotein convertase 5/6 is critical for embryo implantation in women: regulating receptivity by cleaving ebp50, modulating ezrin binding, and membr…

2011

Establishment of endometrial receptivity is vital for successful embryo implantation; its failure causes infertility. Epithelial receptivity acquisition involves dramatic structural changes in the plasma membrane and cytoskeleton. Proprotein convertase 5/6 (PC6), a serine protease of the proprotein convertase (PC) family, is up-regulated in the human endometrium specifically at the time of epithelial receptivity and stromal cell decidualization. PC6 is the only PC member tightly regulated in this manner. The current study addressed the importance and mechanisms of PC6 action in regulating receptivity in women. PC6 was dysregulated in the endometrial epithelium during the window of implantat…

Practices of leisure and life projects among young students in Palermo

2011

Practices of leisure and life projects among young students in Palermo The recent sociological literature on leisure time has pointed out practices of leisure faceted and ambivalent that help to explain some of the main contradictions of modernity. (Lo Verde, 2009, 2011; Roberts, 2006). The interweaving between the practices for the self-realization and the practices characterized by collective and common uses of the leisure time puts in evidence the crucial role that in their structuring have the framework conditions in which social actors live. The existence of social contexts characterized – as already included by Eisenstadt (Eisenstadt, 1973) – by forms of de-differentiation makes more …

miRNA Signature and Dicer Requirement during Human Endometrial Stromal Decidualization In Vitro

2012

Decidualization is a morphological and biochemical transformation of endometrial stromal fibroblast into differentiated decidual cells, which is critical for embryo implantation and pregnancy establishment. The complex regulatory networks have been elucidated at both the transcriptome and the proteome levels, however very little is known about the post-transcriptional regulation of this process. miRNAs regulate multiple physiological pathways and their de-regulation is associated with human disorders including gynaecological conditions such as endometriosis and preeclampsia. In this study we profile the miRNAs expression throughout human endometrial stromal (hESCs) decidualization and analy…

Young adults and the tuning of the entrepreneurial mindset in neoliberal capitalism

2019

Enhancing the entrepreneurial spirit of young people is a means by which their employability and future potential as well as economic growth, the core goal of national policies, are incubated. Consequently, individuals performing entrepreneurial mindset are seen to possess the most future potential. We sketch the contours of this mindset and develop the idea of ‘tuning’ the entrepreneurial mindset with other discursive elements, or ‘ingredients’, available in society in order to make the overarching idea of entrepreneurialism more manageable, bearable, and even enjoyable at the individual level. The ingredients with which the mindset is tuned are non-depressiveness, happiness, and gratefuln…