Search results for "dysfunction"
showing 10 items of 1129 documents
The E3 Ubiquitin Ligase MID1 Catalyzes Ubiquitination and Cleavage of Fu
2014
Sonic Hedgehog (SHH)-GLI signalling plays an important role during embryogenesis and in tumorigenesis. The survival and growth of several types of cancer depend on autonomously activated SHH-GLI signalling. A protein complex containing the ubiquitin-ligase MID1 and protein phosphatase 2A (PP2A) regulates the nuclear localization and transcriptional activity of GLI3, a transcriptional effector molecule of SHH, in cancer cell lines with autonomously activated SHH signalling. However, the exact molecular mechanisms that mediate the interaction between MID1 and GLI3 remained unknown. Here, we show that MID1 catalyses the ubiquitination and proteasomal cleavage of the GLI3-regulator Fu. Our data…
Longitudinal Strain Analysis and Correlation with TIMI Frame Count in Patients with Ischemia with No Obstructive Coronary Artery (INOCA) and Microvas…
2023
Background: The aim of the study is to evaluate the subclinical alterations of cardiac mechanics detected using speckle-tracking echocardiography and compare these data with the coronary angiography indices used during coronary angiography in a population of patients diagnosed with ischemia with no obstructive coronary artery (INOCA) and microvascular angina (MVA). Methods: The study included 85 patients admitted to our center between November 2019 and January 2022 who were diagnosed with INOCA compared with a control group of 70 healthy patients. A collection of anamnestic data and a complete cardiovascular physical examination, and echocardiogram at rest with longitudinal strain were perf…
Marked elevation of transaminases and pancreatic enzymes in severe malnourished male with eating disorder
2013
We report a case of a 45 year old Caucasian malnourished male with an history of eating disorder who developed severe liver and pancreatic damage and multiorgan disfunction. At admission to our department, his body mass index (BMI) was 11.1. Biochemical evaluation showed elevated serum levels of transaminases (AST= 2291 U/L, ALT= 1792 U/L), amylase (3620 U/L), lipase (4102 U/L), CPK= 1370 U/L, LDH= 2082 U/L. No other cause of acute liver and pancreatic damage was evidenced. Haematological disorders (anemia, thrombocytopenia, leukopenia) found on admission seem related to bone marrow hypoplasia and to gelatinous marrow transformation described in severe state of malnutrition. Although a mode…
An update on the relationships between rheumatoid arthritis and atherosclerosis
2010
Rheumatoid arthritis is a chronic inflammatory disease. Cardiovascular events are the most important cause of mortality and morbidity in patients with rheumatoid arthritis. Beyond the traditional cardiovascular risk factors, chronic systemic inflammation has been shown to be a crucial factor in atherosclerosis development and progression from endothelial dysfunction to plaque rupture and thrombosis. Many studies have shown that atherosclerosis is not a passive event like accumulation of lipids in the vessel walls; by contrast, it represents an active inflammation of the vessels. Inflammatory cells such as macrophages, monocytes and T cells play important roles in the development of both rhe…
Scientific evidence on the usefulness of intraarticular hyaluronic acid injection in the management of temporomandibular dysfunction
2010
Abstract Hyaluronic acid (HA) is found in high concentrations in cartilage and synovial fluid, and is an important component of the extracellular matrixes ? exerting joint lubrication and buffering actions thanks to its viscoelastic properties. The present study examines the scientific evidence found in the current literature on the usefulness of the intraarticular injection of HA in patients with temporomandibular dysfunction. A literature search was made up until May 2008 in the following databases: PubMed / MEDLINE. Of the articles found in the literature, the present review included 18 relevant studies on the application of HA in the temporomandibular joint (TMJ). The quality, level of …
Stymulacja pęczka Hisa u osoby starszej z proksymalnym blokiem przedsionkowo-komorowym po zawale mięśnia sercowego
2018
Stymulacja pęczka Hisa (HBP) umożliwia synchronizację przedsionkowo-komorową i międzykomorową. W opisanym przypadku zwrócono uwagę na związek między poziomem bloku, synchronią komorową oraz funkcją rozkurczową u chorego z umiarkowaną dysfunkcją skurczową lewej komory świeżo po zawale serca. HBP jest korzystna w leczeniu zaburzeń przewodzenia i zapobieganiu dalszym zaburzeniom funkcji skurczowej i rozkurczowej. W artykule przedstawiono przypadek 92-letniego mężczyzny w bardzo dobrym stanie psychofizycznym z napadowym blokiem przedsionkowo-komorowym II stopnia i utrwalonym długim odstępem PR w przebiegu zawału mięśnia sercowego bez uniesienia odcinka ST-T, leczonego angioplastyką gałęzi okala…
Modeling of Myotonic Dystrophy Cardiac Phenotypes in
2018
After respiratory distress, cardiac dysfunction is the second most common cause of fatality associated with the myotonic dystrophy (DM) disease. Despite the prevalance of heart failure in DM, physiopathological studies on heart symptoms have been relatively scarce because few murine models faithfully reproduce the cardiac disease. Consequently, only a small number of candidate compounds have been evaluated in this specific phenotype. To help cover this gap Drosophila combines the amenability of its invertebrate genetics with the possibility of quickly acquiring physiological parameters suitable for meaningful comparisons with vertebrate animal models and humans. Here we review available des…
Editorial: Unawareness of Illness in Neurological Disorders: A Focussed Neurocognitive Approach Shedding Light on Neuropsychological Deficits and Neu…
2020
Wpływ stanu napięcia mięśni dna miednicy na ocenę poziomu zaburzeń erekcji i nietrzymania moczu u osób po prostatektomii radykalnej. Doniesienie wstę…
2017
Celem pracy była ocena, jak napięcie mięśni dna miednicy (MDM) mierzonego za pomocą sEMG wpływa na ocenę obiektywną i subiektywną trzymania moczu oraz zaburzeń erekcji. W badaniach uczestniczyło 10 mężczyzn, będących po zabiegu prostatektomii. Nasilenie objawów nietrzymania moczu oceniano na podstawie kwestionariusza ICIQ-SF, aktywność seksualną kwestionariuszem IIEF-5. Nie wykazano istotnego statystycznie związku między napięciem MDM, ocenianego za pomocą sEMG, a obiektywnymi wyznacznikami nietrzymania moczu, jednakże zaobserwowano tendencję, że niższe napięcie MDM występuje częściej u chorych ze wszystkimi dolegliwościami w ocenie subiektywnej.
Effect of Non-Surgical Periodontal Treatment on Oxidative Stress Markers in Leukocytes and Their Interaction with the Endothelium in Obese Subjects w…
2020
Aim: The primary objective of this pilot study was to evaluate the effect of non-surgical periodontal treatment. The secondary aim was to evaluate the effect of dietary therapy on both parameters of oxidative stress in leukocytes and leukocyte-endothelial cell interactions in an obese population. Methods: This was a pilot study with a before-and-after design. Forty-nine obese subjects with periodontitis were randomized by means of the minimization method and assigned to one of two groups, one of which underwent dietary therapy while the other did not. All the subjects underwent non-surgical periodontal treatment. We determined periodontal, inflammatory and oxidative stress parameters&mdash