Search results for "effect"
showing 10 items of 9072 documents
Acute arterial stiffness, testosterone and force production responses and recovery from different combined strength and endurance loading models
2017
Much of the differences between strength (S) and endurance (E) exercise can be attributed to the contrasting endocrinological and molecular responses between the two exercise modes. From the current literature, it seems that aortic arterial stiffness, a reliable cardiovascular mortality predictor, also responds differently to these two modes of exercise. It is thus important to understand the acute responses that combined exercise loads may invoke, as acute responses are known to drive chronic adaptations. Furthermore, testosterone has been cited as a key hormone in cardiovascular protection and its effects may mediate blood flow and hemodynamics. Currently, there are very few studies inves…
Project-Based Education Research Course Supports Exchange-students’ Research Minded Teacher Identity
2022
Project-based education (PBE) gives possibilities for students to work together and feeling of belonging in a community even during distance learning. At the Department of Chemistry, University of Jyväskylä (JYU), a group of exchange students participated in a PBE chemistry teacher education research course online. The goal of the course was to enforce the connection between research on science teaching and acting sustainable in society. This study is based on semi-structured online group interview of the students after this PBE course. The main focus of this investigation was how positive feelings and attitude affect learning. peerReviewed
Kirjallisuuskatsaus vertaisryhmävaikutuksista
2015
On olemassa yleinen käsitys siitä, että ihmisen ominaisuudet määrittyvät hänen läheis-tensä ominaisuuksien perusteella. Tällaista mukautumista kutsutaan vertaisryhmävai-kutuksiksi. Tämän tutkimuksen tarkoitus on tehdä kirjallisuuskatsaus vertaisryhmävai-kutusten parissa tehtävään tutkimukseen yleisellä tasolla, esitellä joitain tutkimuksia hieman yksityiskohtaisemmin ja lisäksi löytää tarkempia vastauksia kysymyksiin ver-taisryhmävaikutusten ilmenemisestä ja vaikutuksista sekä siitä kuinka vertaisryhmävai-kutusten parissa tehtävää tutkimustyötä voitaisiin hyödyntää yhteiskunnallisessa pää-töksenteossa. Tutkimuksen perusteella voidaan todeta, että vertaisryhmävaikutuksilla on merkitystä joka…
An Evaluation Model for Social Work with Substance Abusers
2016
In this article, the research topic is to develop an evaluation model for social work with substance abusers. It is studied by presenting an example of how the evaluation process could be carried out in practice. The study has been implemented with the Department of Social Services and Health Care’s Centre for Recovering Substance Abusers in Finland (RSA Centre). The term “evaluation model” refers to a way of collecting client follow-up information and the way the information is used to develop social work practices. Firstly it is described, how the evaluation model was created at the RSA Centre. Secondly, some results are lifted up to show, what kind of information were used. Finally, it i…
New developments in the management of hepatitis C virus infection: focus on boceprevir
2012
Chronic hepatitis C virus infection is an important public health problem, and the standard treatment (combination of pegylated interferon-α and ribavirin) has an effectiveness rate of only 40%-50%. Novel virus-specific drugs have recently been designed, and multiple compounds are under development. The approval for the clinical use of direct-acting antivirals in 2011 (boceprevir [BOC] and telaprevir, viral NS3 protease inhibitors) has increased recovery rates by up to 70%. Therefore, a highly effective treatment has been envisioned for the first time. This paper focuses on BOC and the implementation of new BOC-based treatment regimes.
Microtubules and microfilaments in HSV-Infected rabbit-kidney cells.
1981
In rabbit kidney cells infected with strains of Herpes simplex virus producing either cell-rounding or polycaryocytosis. Vinblastine induced paracrystals. This could be shown by phase-contrast- and electron-microscopy. Infections were done under one-step-growth conditions or at low MOI. 90 per cent noninfected cells contained stress fibers as detected by Servablue R250-staining. Shortly after recruitment into polycaryocytes, stress fibres of normal length appearing in criss-cross arrangement can be seen in the periphery of these cells. Later they polymerize to very long fibers and finally they are partially destroyed. The time of destruction depends on the MOI employed. By using Actinomycin…
Single amino acid substitutions in the glycoprotein B carboxy terminus influence the fusion from without property of herpes simplex virus type 1.
1995
Syncytial mutations of herpes simplex virus type 1 (HSV-1) strains ANG, ANG path, HFEM, tsB5 and HSZP cause extensive cell fusion and were mapped to the cytoplasmic domain of glycoprotein B (gB), within the syn 3 locus. These strains are so far the only ones which show the phenotype ‘fusion from without’ (FFWO): 60 min after infection with high m.o.i., cells in a tissue culture are fused without transcription and translation of the viral genome. In this report we detected, using the recombinants 27/III and K-7, that an amino acid exchange from Ala to Val at aa position 854 of gB is the main determinant for FFWO activity of strains ANG, ANG path and recombinant K-7. The transfer of this muta…
SV40 transformed fibroblasts recognize the same 140 kD fibronectin chemotactic fragment as non-transformed cells
1985
SV40-virus-transformed human embryonal fibroblasts show an enhanced chemotactic response to the glycoprotein fibronectin. However, they recognize the same chemotactic active region as non-transformed fibroblasts. The result suggests that an enhancement of chemotaxis by fibroblasts which have been transformed with Simian Virus 40 is due not to the utilization of further chemotactic domains in the molecule, but to an increased sensitivity of the cells to the chemoattractant.
The mechanism of retro-cue effect in visual working memory : Cognitive phase separation
2020
Retro-cue effect (RCE) refers to the phenomenon that individuals can use retro-cues to improve their visual working memory (VWM) performance of target items after memory stimuli disappear. To explain the mechanism of RCE in VWM, five different hypotheses have been proposed by previous studies: the hypothesis of enhancing target representations, the hypothesis of forgetting non-target representations, the hypothesis of preventing memory degradation, the hypothesis of preventing interference from probe array and the hypothesis of cognitive phase separation. Although RCE has been repeatedly observed in previous studies, the mechanism of RCE remains unclear. In this study, we conducted three ex…
Positive Effects of Videogame Use on Visuospatial Competencies: The Impact of Visualization Style in Preadolescents and Adolescents
2019
Use of videogames (VGs) is almost ubiquitous in preadolescents' and adolescents' everyday life. One of the most intriguing research topics about positive effects of VG use is about the domain of visuospatial competencies. Previous research show that training with videogames enables children and adolescents to improve their scores in visuospatial tests (such as mental rotation of shapes and cubes), and that such training could overcome gender differences in these domains. Our study aimed at (1) verifying the positive effects of videogame use in the visuospatial domain both for male and female adolescents and preadolescents and (2) verifying whether the visualization style (2D or isometric 3D…