Search results for "elderly."
showing 10 items of 850 documents
Implementing Precision Medicine in Human Frailty through Epigenetic Biomarkers
2021
The main epigenetic features in aging are: reduced bulk levels of core histones, altered pattern of histone post-translational modifications, changes in the pattern of DNA methylation, replacement of canonical histones with histone variants, and altered expression of non-coding RNA. The identification of epigenetic mechanisms may contribute to the early detection of age-associated subclinical changes or deficits at the molecular and/or cellular level, to predict the development of frailty, or even more interestingly, to improve health trajectories in older adults. Frailty reflects a state of increased vulnerability to stressors as a result of decreased physiologic reserves, and even dysregu…
Social frailty increases the risk of all-cause mortality: A longitudinal analysis of the English Longitudinal Study of Ageing
2022
Objectives\ud Social frailty is a common condition in older people, but its consequences are largely unknown. Therefore, in this longitudinal analysis, we aimed to investigate the association between social frailty and risk of all-cause mortality in a large sample of older people.\ud Design\ud Longitudinal, cohort.\ud Settings and participants\ud Older people participating to the English Longitudinal Study of Ageing (ELSA).\ud Methods\ud Social frailty was defined based on financial difficulty, household status, social activity, and contacts with other people: social frailty was defined as ≥2 points, social pre-frailty (1 point), and robustness (0 points). Survival status during ten years o…
Association of frailty with fall events in older adults: A 12-year longitudinal study in Korea
2022
Background: Evidence has shown that frailty is associated with the risk of falls in older people. However, the components of frailty that have the highest association with fall events are largely unknown. Methods: This study analyzed panel data from the Korean Longitudinal Study of Aging. We used the Korean Frailty Instrument, which includes domains for social isolation, exhaustion and weakness estimated by grip strength, to assess frailty. Fall event data were collected during follow-up visits. Results: A total of 3122 community-dwelling adults aged 65 years or older were included at baseline in 2006 and were followed up every 2 years until 2018. The participants with frailty had a higher …
Outdoor mobility and social relationships of elderly people.
1997
Social relationships and activities are important elements in the quality of life of older people. With advancing age, they are made more difficult through the possible loss of physical functions, through societal processes of differentiation, and through unfavourable environmental and technological conditions. Therefore, mobility becomes a fundamental prerequisite for the participation in social relations and activities. This article presents some initial findings of a project which investigates the mobility needs of the elderly and the main factors hindering their desired mobility in three European countries. It became apparent that there is a clear connection between the social situation…
Building Bridges for Innovation in Ageing: Synergies between Action Groups of the EIP on AHA.
2017
The Strategic Implementation Plan of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) proposed six Action Groups. After almost three years of activity, many achievements have been obtained through commitments or collaborative work of the Action Groups. However, they have often worked in silos and, consequently, synergies between Action Groups have been proposed to strengthen the triple win of the EIP on AHA. The paper presents the methodology and current status of the Task Force on EIP on AHA synergies. Synergies are in line with the Action Groups' new Renovated Action Plan (2016-2018) to ensure that their future objectives are coherent and fully connected. The …
The place of frailty and vulnerability in the surgical risk assessment: should we move from complexity to simplicity?
2018
Due to aging of the world population, older patients accessing health services are becoming continuously more frequent. This has increased the interest in assessing frailty and vulnerability in all specialties and general medicine. Although the term frailty has been recognized for over 30 years, there is not yet a universally recognized definition, and different care providers assess frailty and vulnerability with dissimilar tools, from very complex to very simple validated scales. Being treated with respect and dignity at the right time and place is the key message, as well as after undergoing a global evaluation both in urgency/emergency and in programmed surgery for all older surgical pa…
Immunosenescence and anti-immunosenescence therapies: the case of probiotics.
2008
ABSTRACT Aging is a complex process that negatively impacts the development of the immune system and its ability to function. Progressive changes in the T and B cell systems over the life span have a major impact on the capacity to respond to immune challenge. These cumulative age-associated changes in immune competence are termed immunosenescence. This process is mostly characterized by: (1) shrinkage of the T cell repertoire and accumulation of oligoclonal expansions of memory/effector cells directed toward ubiquitary infectious agents; (2) involution of the thymus and the exhaustion of naive T cells; and (3) chronic inflammatory status. Here we discuss possible strategies to counteract t…
Contribution of the physical, social, psychological and environmental domains to overall quality of life of the elderly
2006
Este estudo investigou a contribuição de cada domínio da qualidade de vida (físico, social, psicológico e ambiental) na qualidade de vida global e em que extensão esses domínios explicam a qualidade de vida global de idosos residentes no município de Teixeiras, na Região Sudeste do Brasil. Trata-se de um estudo observacional de corte transversal, sendo a amostragem aleatória estratificada por sexo, uso do Programa Saúde da Família e microárea de saúde (n = 211, indivíduos com idade igual ou superior a 60 anos), representando 14,28% do total de idosos do município em estudo. O instrumento utilizado foi o Word Health Organization Quality of Life Instrument Bref (WHOQOL-Bref), proposto pela Or…
Résidents et personnel en établissement d'hébergement pour personnes agées dépendantes (EHPAD) : création ou recréation de liens spécifiques en milie…
2019
This thesis studies the specific relationship that develops between the staff, the residents and their family and friends in retirement homes for dependents elderly in a rural environment.The aim is to analyse the creation process by the actors to go from an acquaintanceship network to an interdependence network and how each adapts, reorganise, more or less, among facilities where the legislator codified strongly the relational framework.The arrival to a retirement home marks, in all cases, a strong biographical break. For a little of people, it means having to accept abandoning a significant part of their past life. It forces the residents to (re)build themselves a new identity, a new stat…
The effect of resistance training programs on lean body mass in postmenopausal and elderly women: a meta-analysis of observational studies
2021
AbstractAging and menopause are associated with morphological and functional changes which may lead to loss of muscle mass and therefore quality of life. Resistance training (RT) is an effective training mode to increase muscle mass. We reviewed the existing literature to identify studies implementing RT protocols and evaluating muscle hypertrophy exclusively in healthy, postmenopausal and elderly women. Participants’ age range was comprised between 50 and 80 years. The primary outcome observed was muscle hypertrophy. Fat mass was also evaluated, if available. PubMed and Web of Science were the screened database, and original articles written in English and published from 2000 up to 2020 we…