Search results for "emulsion"
showing 10 items of 344 documents
Acute in vivo administration of a fish oil-containing emulsion improves post-ischemic cardiac function in n-3-depleted rats
2006
International audience; A novel i.v. lipid preparation (MCT:FO) containing 80% medium chain-triacylglycerols and 20% fish oil was recently developed to rapidly replenish cell membrane phospholipids with omega 3 (n-3) polyunsaturated fatty acids (PUFA). In regard of this property, we investigated the effect of a single i.v. administration of MCT:FO on the recovery of cardiac function after ischemia in control and n-3-depleted rats. Results were compared with those obtained either with a control preparation, where FO was replaced by triolein (MCT:OO), or with saline. Saline (1 ml) or lipid preparation (also 1 ml) was injected as a bolus via the left saphenous vein. After 60 min the heart was …
Anti-inflammatory and anti-fibrotic profile of fish oil emulsions used in parenteral nutrition-associated liver disease.
2014
Home parenteral nutrition (PN) is associated with many complications including severe hepatobiliary dysfunction. Commercial ω-6 fatty acid-soybean based-lipid emulsions in PN may mediate long term PN associate liver disease (PNALD) whereas ω-3-fish oil parenteral emulsions have shown to reverse PNALD in children. However, its clinical effectiveness in adults has been scarcely reported. In this work, we study the role of soybean and fish oil lipid commercial emulsions on inflammatory and profibrotic liver markers in adults with long term PNALD and in in vitro cellular models. Inflammatory and profibrotic markers were measured in serum of ten adults with long term PNALD and in culture superna…
Ocular tolerability and in vivo bioavailability of poly(ethylene glycol) (PEG)-coated polyethyl-2-cyanoacrylate nanosphere-encapsulated acyclovir.
2001
Acyclovir-loaded polyethyl-2-cyanoacrylate (PECA) nanospheres were prepared by an emulsion polymerization process in the micellar phase and characterized. The influence of the presence of nonionic surfactant as well as other substances [i.e., 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CyD) and poly(ethylene glycol) (PEG)], on formulation parameters and loading capacity was investigated. In particular, the presence of PEG resulted in an increase of mean size and size distribution. To obtain PEG-coated PECA nanospheres with a mean size of200 nm, Pluronic F68 at concentrations1.5% (w/v) should be used during preparation. The presence of PEG also resulted in a change in zeta potential, from -25…
Pre-clinical assessment of a water-in-fluorocarbon emulsion for the treatment of pulmonary vascular diseases
2019
Abstract Hypoxic pulmonary vasoconstriction (HPV) is a well-characterized vascular response to low oxygen pressures and is involved in life-threatening conditions such as high-altitude pulmonary edema (HAPE) and pulmonary arterial hypertension (PAH). While the efficacy of oral therapies can be affected by drug metabolism, or dose-limiting systemic toxicity, inhaled treatment via pressured metered dose inhalers (pMDI) may be an effective, nontoxic, practical alternative. We hypothesized that a stable water-in-perfluorooctyl bromide (PFOB) emulsion that provides solubility in common pMDI propellants, engineered for intrapulmonary delivery of pulmonary vasodilators, reverses HPV during acute h…
Ablative fractional laser-assisted photodynamic therapy for lentigo maligna: a prospective pilot study.
2019
Background Lentigo maligna (LM) is an in‐situ form of melanoma carrying a risk of progression to invasive lentigo maligna melanoma (LMM). LM poses a clinical challenge, with subclinical extension and high recurrence rates after incomplete surgery. Alternative treatment methods have been investigated with varying results. Photodynamic therapy (PDT) with methylaminolaevulinate (MAL) has already proved promising in this respect. Objectives To investigate the efficacy of ablative fractional laser (AFL)‐assisted PDT with 5‐aminolaevulinic acid nanoemulsion (BF‐200 ALA) for treating LM. Methods In this non‐sponsored, prospective pilot study ten histologically verified LMs were treated with AFL‐as…
Synergy of Miniemulsion and Solvothermal Conditions for the Low-Temperature Crystallization of Magnetic Nanostructured Transition-Metal Ferrites
2017
Crystalline first-row transition-metal (Mn, Fe, Co, Ni, Cu, and Zn) ferrites were prepared by an unprecedented synergetic combination of miniemulsion synthesis and solvothermal route, pursuing unconventional conditions in terms of space confinement, temperature, and pressure. This synergy allowed for obtaining six different crystalline ferrites at much lower temperature (i.e., 80 °C) than usually required and without any postsynthesis thermal treatment. X-ray diffraction (XRD) revealed that analogous ferrites synthesized by miniemulsion at ambient pressure or in bulk (i.e., from an aqueous bulk solution and not in the confined space of the miniemulsion droplets) either at ambient pressure o…
Synthesis of yttrium aluminum garnet nanoparticles in confined environment II: Role of the thermal treatment on the composition and microstructural e…
2017
Abstract Nanoparticles of yttrium aluminum garnet (YAG, Y 3 Al 5 O 12 ) have been obtained by thermal treatments, at several temperature in the range 400–950 °C, of the precursors synthetized via co-precipitation in water in oil microemulsion. The obtained nanoparticles have been characterized by means of X-ray Diffraction and Transmission Electron Microscopy coupled with Energy Dispersive X-ray Spectroscopy (EDS) and Select Area Electron Diffraction (SAED). Results show the phase evolution occurring to obtain not aggregated nanoparticles of YAG phase. A possible growth mechanism of YAG nanoparticles is discussed on the basis of observed particle microstructure and morphology. The results i…
Nanoemulsions for synthesis of biomedical nanocarriers
2021
Nanoemulsions are kinetically stabilized emulsions with droplet sizes in the nanometer scale. These nanodroplets are able to confine spaces in which reactions of polymerization or precipitation can take place, leading to the formation of particles and capsules that can act as nanocarriers for biomedical applications. This review discusses the different possibilities of using nanoemulsions for preparing biomedical nanocarriers. According to the chemical nature, nanocarriers prepared in nanoemulsions are classified in polymeric, inorganic, or hybrid. The main synthetic strategies for each type are revised, including miniemulsion polymerization, nanoemulsion-solvent evaporation, spontaneous em…
In Silico Design Enables the Rapid Production of Surface-Active Colloidal Amphiphiles
2020
A new technology platform built on the integration of theory and experiments to enable the design of Janus colloids with precision control of surface anisotropy and amphiphilicity could lead to a disruptive transformation in the next generation of surfactants, photonic or phononic materials, and coatings. Here, we exploit molecular dynamics (MD) simulations to guide the rational design of amphiphilic polymer Janus colloids by Flash NanoPrecipitation (FNP), a method capable of the production of colloids with complex structure without the compromise of reduced scalability. Aided by in silico design, we show in experiments that amphiphilic Janus colloids can be produced using a unique blend of…
Nonionic Aliphatic Polycarbonate Diblock Copolymers Based on CO2, 1,2-Butylene Oxide, and mPEG: Synthesis, Micellization, and Solubilization
2019
Carbon dioxide (CO2) is a renewable carbon source that is easily available in high purity and is utilized as a co-monomer in the direct ring-opening polymerization of epoxides to obtain aliphatic polycarbonates. In this work, degradable aliphatic polycarbonate diblock copolymers (mPEG- b-PBC) are synthesized via catalytic copolymerization of CO2 and 1,2-butylene oxide, starting from monomethoxy poly(ethylene glycol) (mPEG) as a chain transfer reagent. The polymerization proceeds at low temperatures and high CO2 pressure, utilizing the established binary catalytic system ( R, R)-Co(salen)Cl/[PPN]Cl. Amphiphilic nonionic diblock copolymers with varying PBC block lengths and hydrophilic-lipoph…