Search results for "endocrine system"

Occurrence and removal of organic pollutants in sewages and landfill leachates

2002

Sewages of different composition and the effluents of four sewage treatment plants (STPs), plus sewage sludges were analysed for semivolatile organic priority pollutants. Furthermore, 11 landfill leachates were analysed to evaluate their contribution to sewage pollutants when co-treated. Bis(2-ethylhexyl) phthalate (DEHP) was the pollutant occurring at highest concentrations (up to 122 microg/l) and it was present in all sewages and leachates; concentrations of other phthalates were usually below 17 microg/l. Some polycyclic aromatic hydrocarbons (PAH) (<1 microg/l) and 2,6-dinitrotoluene (< or =5.9 microg/l) were also present in many of the sewages and leachates. Phthalates were present in…

Removal of bis(2-ethylhexyl) phthalate at a sewage treatment plant

2003

Bis(2-ethylhexyl) phthalate (DEHP) concentrations were measured at different stages in a full-scale sewage treatment plant (STP) and mass balances were calculated. The DEHP load to treatment process coming from the sewer system and the internal load comprising returned supernatants and filtrate from sludge treatment and excess secondary sludge were at the same level. The DEHP removal efficiency from the water phase at the STP was on average 94% of sewage DEHP, the main removal process being sorption to primary and secondary sludges. On average 29% of DEHP was calculated to be removed in the biological nitrifying-denitrifying activated sludge process, which was much less than expected from l…

Some aspects related to stability, critical concentrations and kinetics of flocculation of the calcium phytate colloid

1986

Abstract As 99mTcCa phytate is an important radiopharmaceutical and its colloidal nature presents problems, we investigated some of them. This work describes the study of the colloidal behaviour of the calcium phytate colloid in terms of its formation, stability and kinetics of flocculation. The study of spontaneous, and centrifugation-induced flocculation allows the determination of two critical concentrations of sol flocculation. The titrations of calcium phytate colloid at different concentrations provide information on the colloidal formation conditions. Moreover, a study on flocculation kinetics was made by turbidity measurements.

A Tunable, Fullerene‐Based Molecular Amplifier for Vibrational Circular Dichroism

2019

Abstract Vibrational circular dichroism (VCD) studies are reported on a chiral compound in which a fullerene C60 moiety is used as an electron acceptor and local VCD amplifier for an alanine‐based peptide chain. Four redox states are investigated in this study, of which three are reduced species that possess low‐lying electronic states as confirmed by UV/Vis spectroelectrochemistry. VCD measurements in combination with (TD)DFT calculations are used to investigate (i) how the low‐lying electronic states of the reduced species modulate the amplification of VCD signals, (ii) how this amplification depends on the distance between oscillator and amplifier, and (iii) how the spatial extent of the…

Systematic review: the presenting international normalised ratio (INR) as a predictor of outcome in patients with upper nonvariceal gastrointestinal …

2011

Aliment Pharmacol Ther 2011; 33: 1010–1018 Summary Background  The prognostic value of an elevated international normalised ratio (INR) as part of initial risk stratification in nonvariceal upper gastrointestinal bleeding (NVUGIB) remains poorly characterised. Aim  To assess the usefulness of the initial INR in patients with NVUGIB. Method  After a systematic review, we included the presenting INR and other validated prognosticators in multivariable models predicting rebleeding and mortality. Data are reported as odd ratios and 95% confidence intervals. Results  Only two of 769 candidate studies were useful, but reported disparate, highly selected NVUGIB patients with varying threshold init…

2002

Analysis of gonad organization and development revealed that Serranus atricauda is a functional simultaneous hermaphrodite. The ovary is classified as asynchronous. Oocyte growth is divided into five stages: stage I (primary growth stage), stage II (yolk vesicle formation), stage III (vitellogenesis), stage IV (oocyte maturation) and stage V (mature egg). The testis is of the unrestricted or lobular spermatogonial type. Spermatogenic cells include spermatogonia, primary and secondary spermatocytes, spermatids (which form cysts in the seminiferous tubules) and spermatozoa (free in the lumen). The histological structure of the gonad and sperm morphology would seem to indicate that this specie…

Isolation of Zebrafish Gonads for RNA Isolation

2013

Piwi proteins and piRNAs are abundant in the gonads of various animal species. Gonads from different developmental stages provide us information regarding the function of piRNAs and the PIWI pathway during germline development. Here we describe methods for gonad and germ cell preparation from different developmental stages of zebrafish. We also describe how to use these gonads to purify and characterize piRNAs.

A mutation in the second intracellular loop of the pituitary adenylate cyclase activating polypeptide type I receptor confers constitutive receptor a…

2000

AbstractThe pituitary adenylate cyclase activating polypeptide (PACAP) type I receptor belongs to the glucagon/secretin/vasoactive intestinal polypeptide (VIP) receptor family. We mutated and deleted an amino acid residue (E261) which is located within the second intracellular loop of the rat PACAP type I receptor and which is highly conserved among the receptor family. The wild-type receptor and the mutant receptors were efficiently expressed at the surface of COS-7 cells at nearly the same level and revealed the same high affinity for the agonist PACAP-27. The cAMP contents of COS cells transfected with the E261A, E261Q, and the deletion mutant receptor were 4.6-, 5.7-, and 6.7-fold highe…

Prognostic and Functional Significant of Heat Shock Proteins (HSPs) in Breast Cancer Unveiled by Multi-Omics Approaches

2021

Simple Summary In this study, we investigated the expression pattern and prognostic significance of the heat shock proteins (HSPs) family members in breast cancer (BC) by using several bioinformatics tools and proteomics investigations. Our results demonstrated that, collectively, HSPs were deregulated in BC, acting as both oncogene and onco-suppressor genes. In particular, two different HSP-clusters were significantly associated with a poor or good prognosis. Interestingly, the HSPs deregulation impacted gene expression and miRNAs regulation that, in turn, affected important biological pathways involved in cell cycle, DNA replication, and receptors-mediated signaling. Finally, the proteomi…

Secondary hemophagocytic lymphohistiocytosis in zoonoses. A systematic review

2012

BACKGROUND: Hemophagocytic lymphohistiocytosis (HLH) is a rare syndrome that is often fatal despite treatment. It is caused by a dysregulation in natural killer T-cell function, resulting in activation and proliferation of histiocytes with uncontrolled hemophagocytosis and cytokines overproduction. The syndrome is characterized by fever, hepatosplenomegaly, cytopenias, liver dysfunction, and hyperferritinemia. HLH can be either primary, with a genetic aetiology, or secondary, associated with malignancies, autoimmune diseases, or infections. AIM: To focus on secondary HLH complicating zoonotic diseases. MATERIALS AND METHODS: PubMed search of human cases of HLH occurring during zoonotic dise…