Search results for "endocrine"
showing 10 items of 2114 documents
Lipid-Altering Efficacy of Ezetimibe/Simvastatin 10/20 mg Compared to Rosuvastatin 10 mg in High-Risk Patients with and without Type 2 Diabetes Melli…
2010
SUMMARY Aims: This post hoc analysis compared the effects of switching to ezetimibe/simvastatin 10/20 mg (EZE/SIMVA) or rosuvastatin 10 mg (ROSUVA) in uncontrolled high-risk hypercholesterolemic patients with/without type 2 diabetes mellitus (T2DM) despite statin monotherapy. Methods: Patients (n = 618) at high risk for coronary vascular disease with elevated LDL-C ≥100 and ≤190 mg/dL despite use of statins were randomized 1:1 to double-blind EZE/SIMVA 10/20 mg or ROSUVA 10 mg for 6 weeks. Patients were classified as having T2DM based on ≥1 of the following: diagnosis of T2DM, antidiabetic medication, or FPG ≥126 mg/dL. This analysis evaluated percent changes from baseline in lipids among p…
Quantum dots functionalised artificial peptides bioinspired to the D1 protein from the Photosystem II of Chlamydomonas reinhardtii for endocrine disr…
2021
Herein we describe the design and synthesis of novel artificial peptides mimicking the plastoquinone binding niche of the D1 protein from the green photosynthetic alga Chlamydomonas reinhardtii, also able to bind herbicides. In particular, molecular dynamics (MD) simulations were performed to model in silico the behaviour of three peptides, D1Pep70-H, D1Pep70-S264K and D1Pep70-S268C, as genetic variants with different affinity towards the photosynthetic herbicide atrazine. Then the photosynthetic peptides were functionalised with quantum dots for the development of a hybrid optosensor for the detection of atrazine, one of the most employed herbicides for weed control in agriculture as well …
Immunohistochemical Characterization of Human Synovial Bursa Cells by Light and Transmission Electron Microscopy: Where do These Cells Come From?
2007
En el presente estudio se examinaron bolsas sinoviales humanas a traves de microscopia de luz y electronica de transmision. Para la microscopia de luz, el tejido de las bolsas se tino con Azan, H-E y anticuerpos monoclonales (CD14, CD33, CD36, CD68, laminina). Para la microscopia electronica las bolsas fueron fijadas con solucion de Karnovsky y tetroxido de osmio al 1,5% (Os04) en agua destilada y contrastada con acetato de uranilo al 5% y embebido en Epon®. En primera instada, el fenotipo antigenico fue caracterizado, concluyendose acerca del origen de las celulas que componen la bolsa sinovial. Histologicamente la bolsa fue dividida en dos capas distintas - la intima - la cual es formada …
Instabilities of infinite matter with effective Skyrme-type interactions
2002
The stability of the equation of state predicted by Skyrme-type interactions is examined. We consider simultaneously symmetric nuclear matter and pure neutron matter. The stability is defined by the inequalities that the Landau parameters must satisfy simultaneously. A systematic study is carried out to define interaction parameter domains where the inequalities are fulfilled. It is found that there is always a critical density $\rho_{cr}$ beyond which the system becomes unstable. The results indicate in which parameter regions one can find effective forces to describe correctly finite nuclei and give at the same time a stable equation of state up to densities of 3-4 times the saturation de…
M4_Microfluidics_for_CNT
2018
Size and frequency of the droplets produced in T-junction as a function of continuous and disperse phase pressure ratio.
M7_Microfluidics_for_CNT
2018
A comparation of two designs of a droplet trap. While the droplet exchange is mediated by direct droplet contact in the symmetric design, a short continuous phase plug mediated the droplet exchange in the asymmetric design.
M3_Microfluidics_for_CNT
2018
Droplet production in T-junction microfluidic device. The droplets are cut off from the water phase flow by pressure of oil. The droplets confined in the channel proceed at the same speed as the continuous phase.
M1_Microfluidics_for_CNT
2018
High-frequency droplet production in step-emulsification microfluidic device. The abrupt change in channel cross section causes creation of the droplets. The closely-packed droplets automatically order in hexagonal pattern.
A novel arousal-based individual screening reveals susceptibility and resilience to PTSD-like phenotypes in mice
2021
Translational animal models for studying post-traumatic stress disorder (PTSD) are valuable for elucidating the poorly understood neurobiology of this neuropsychiatric disorder. These models should encompass crucial features, including persistence of PTSD-like phenotypes triggered after exposure to a single traumatic event, trauma susceptibility/resilience and predictive validity. Here we propose a novel arousal-based individual screening (AIS) model that recapitulates all these features. The AIS model was designed by coupling the traumatization (24 h restraint) of C57BL/6 J mice with a novel individual screening. This screening consists of z-normalization of post-trauma changes in startle …
Mapping Brain Response to Social Stress in Rodents With c-fos Expression: A Review
2002
Social defeat is an important event in the life of many animals, and forms part of the process of social control. Adapting to social defeat is thus an intrinsic part of social "homeostasis", and mal-adaptation may have pathological sequelae. Experimental models of social defeat (e.g. inter-male aggression) have existed for many years. However, very few studies have investigated the changes in brain activity in male animals exposed to the social stress of being defeated by another conspecific male, and in all these studies the expression of the immediate-early gene c-fos has been used as the marker of neuronal activity. In general, the results obtained inform that many areas of the brain, es…