Search results for "enviroment"
showing 10 items of 21 documents
γδ cells and tumor microenvironment: A helpful or a dangerous liason?
2017
Abstract γδ T cells are a subset of T lymphocytes that have been implicated in immunosurveillance against infections and tumors. γδ T cells are endowed with antitumor activities, and hence several γδ T cell-based small-scale clinical trials have been conducted either by in vivo activation by intravenous administration of aminobiphosphonates or by adoptive transfer of in vitro expanded γδ T cells. Although both these strategies have yielded promising results, there are a number of limitations associated with each of them which, if overcome may help to further improve efficacy. One of the most important limits is the possible polarization of tumor-infiltrating γδ T cells toward different γδ T…
Long-Term Remission Achieved by Ponatinib and Donor Lymphocytes Infusion in a Ph+ Acute Lymphoblastic Leukemia Patient in Molecular Relapse After All…
2020
Currently, the prognosis of Ph+ acute lymphoblastic leukemia (Ph+ ALL) patients relapsing after an allogenic hematopoietic stem cell transplantation (allo-SCT) remains poor, with few therapeutic options available. Here we present the case of a 32 years old patient with dasatinib-resistant post-transplant molecular relapse of ALL, who received, as second-line therapy, the combination of ponatinib and donor lymphocyte infusion (DLI). The therapy was safe and the patient achieved a sustained minimal residual disease negative disease, still ongoing after 22 months, which was accompanied by several changes in the immune populations distribution within the bone marrow (i.e., the increase in the C…
Diseño e implementación de una aplicación en Processing para la representación visual de datos multidimensionales utilizando técnicas de Minería de D…
2015
La posibilidad de disponer de representaciones gráficas de los datos es de gran valor a la hora de extraer conocimiento útil. Sus principales ventajas son la visualización de información de una forma sencilla, rápida y directa. No obstante, muchos de los conjuntos de datos contienen numerosos registros, que pueden ser de naturaleza multivariante. En estos casos, la representación visual de datos se convierte en una tarea complicada y las técnicas clásicas que suelen utilizarse obtienen resultados poco intuitivos. Esta tesis se plantea como objetivo el diseño e implementación de una aplicación versátil capaz de representar visualmente gran cantidad de datos multidimensionales de forma eficaz…
Challenges in Energy Systems for the Smart-Cities of the Future
2012
In the last years the European Union has actively promoted the renewable energies and the Combined Heat and Power (CHP) also for residential and tertiary buildings. The exploitation of renewable sources and cogeneration seems hampered by the regulatory wall that prohibit for residential, tertiary and commercial buildings the constitution of users clusters. In fact, the unification up to a threshold value of some tens of kVA, at least, can facilitate the installation of renewable energy power plants as solar PV modules or CHP systems (cogeneration) or CCHP systems (tri-generation), overcoming technical and economical barriers and combining several load profiles. The actual distribution syste…
The sterilization of eco-criticism: from sustainable development to green capitalism
2015
[eng] Development has been a dominant and highly visible trope of the global political and economic life of the world since the 1950s. As such it has been inevitably linked to some of the most important social processes of this era: colonialism, globalization, postcolonialism, global ecological crisis, the rise of environmentalism, and more. The consolidation of the contemporary consumer global society came, hand by hand, with the certainty that it sustained a way of life that as a collateral damage, included a global ecological crisis. From many quarters of the world new voices raised concerns about the costs of globalization and proposed alternatives and solutions: modern eco-criticism wa…
The sterilization of eco-criticism: from sustainable development to green capitalism
2015
El desarrollo ha sido un tropo dominante de la vida política y económica global en el mundo desde 1950. Como tal ha estado inevitablemente conectado a algunos de los procesos sociales más importantes de esta era: colonialismo, globalización, post-colonialismo, crisis ecológica global, el crecimiento del ecologismo, entre otros. La consolidación de la sociedad del consumo contemporánea llegó de la mano de la certeza de que sostenía un sistema de vida que, como daño colateral, incluía una crisis ecológica global. Desde muchos lugares del mundo nuevas voces apuntaron críticas en relación a los costes de la globalización y propusieron alternativas y soluciones: el eco-criticismo. Este artículo …
El problema de la generación de residuos urbanos entre los contenidos de geografía de la enseñanza secundaria obligatoria
2002
Una de las características del problema de los Residuos Urbanos en nuestro país es la escasa conciencia ambiental de los ciudadanos. En este trabajo se exponen las grandes posibilidades que ofrece el currículo del Área de “Ciencias Sociales, Geografía e Historia” de la Enseñanza Secundaria Obligatoria (E.S.O.) para llevar a cabo acciones de Educación Ambiental, destacando así la capacidad de los profesores de Geografía para intentar mejorar la situación actual. Solid wastes generation problem into Secondary School Geography´s contents Citizenship’s low environmental conscience is a characteristic of Solid Wastes situation in Spain. In this paper, “Social Sciences, Geography and History” cur…
Vides aizsardzības kluba darbība 1987-1989
2021
Maģistra darba mērķis ir raksturot Vides Aizsardzības kluba laika periodā no 1987.–1989. gadam un izvērtēt organizācijas nozīmi Latvijas atmodas procesos. Aplūkoto laika periodu raksturo plašas politiskās izmaņas PSRS, kuru rezultāta sākas plašāka sabiedrības iesaiste politiskajos procesos. Pētījumā tiek sniegts ieskats organizācijas priekšvēsturē un izveidē, tās galvenajos darbības virzienos, problēmjautājumos, kuru risināšanā organizācija iesaistījās visplašāk, kā arī iemeslos, kādēļ 1989. gadā klubs nolēma kļūt par apolitisku organizāciju. Maģistra darbā izmantoti Latvijas valsts arhīvā un Zaļās Atmodas muzejā pieejamie materiāli par VAK darbību, tostarp organizācijas dibināšanas materiā…
Neoanthropocene Raising and Protection of Natural and Cultural Heritage: A Case Study in Southern Italy
2020
Analyzing the human history on the planet, a conflictual relation was raised when humankind had started destroying the natural ecosystem and biota, and consequently, a capacity to induce environmental change has increased throughout human history in the so-called Anthropocene age. A 'noosphere'-centered civilization could produce a non-disruptive new kind of anthropocentrism. This is becoming a new context to define Neoanthropocene based on a renewed homeostatic relationship between Earth and mankind. The potential application of this theoretical approach has been tested in drafting steps of Plan of Lucania Apennines, Valdagri, and Lagonegrese National Park, in southern Italy. Drafting the …
General Overview
2016
Il capitolo introduce alla tematica smart city attraverso un exscursus storico che ne traccia i passaggi salienti: la nascita delle politiche globali ambientali sino al livello della maturità raggiunto con il Protocollo di Kyoto (1997); poi ancora il Pacchetto Clima 20-20-20 redatto dalla Commissione Europea nel 2008 che traccia un'altro punto cruciale che prelude ai progetti e alle iniziative in ambito smart cities. La Strategia Energetica Europea al 2050 rappresenta il quadro di riferimento a cui tendere. Il capitolo si conclude con una rassegna dei sistemi di ranking più popolari e con una proposta di analisi. The chapter introduces to smart city issue through a historical excursus, whic…