Search results for "epidemiologic methods"

showing 10 items of 109 documents

Spatial analysis of the relationship between mortality from cardiovascular and cerebrovascular disease and drinking water hardness

2004

Journal Article; Research Support, Non-U.S. Gov't; Reproduced with permission from Environmental Health Perspectives. Previously published scientific papers have reported a negative correlation between drinking water hardness and cardiovascular mortality. Some ecologic and case-control studies suggest the protective effect of calcium and magnesium concentration in drinking water. In this article we present an analysis of this protective relationship in 538 municipalities of Comunidad Valenciana (Spain) from 1991-1998. We used the Spanish version of the Rapid Inquiry Facility (RIF) developed under the European Environment and Health Information System (EUROHEIS) research project. The strateg…

GerontologyMaleMini-Monograph: Information SystemsHealth Toxicology and MutagenesisWater supply:Named Groups::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings]Disease:Health Care::Environment and Public Health::Public Health::Sanitation::Sanitary Engineering::Water Supply [Medical Subject Headings]Magnesio:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]PreescolarMediana EdadReference ValuesExposición a Riesgos AmbientalesMedicineCluster AnalysisMagnesiumMasculinoChildEnfermedades Cardiovascularesgeographic information systems:Named Groups::Persons::Age Groups::Child::Child Preschool [Medical Subject Headings]:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Weights and Measures::Reference Values [Medical Subject Headings]AdultoAguaEpidemiologic SurveillanceEnvironmental exposureMiddle AgedHumanos:Health Care::Environment and Public Health::Public Health::Environmental Pollution::Environmental Exposure [Medical Subject Headings]Abastecimiento de aguarelative risk:Information Science::Information Science::Information Storage and Retrieval::Databases as Topic::Databases Factual::Geographic Information Systems [Medical Subject Headings]Cardiovascular DiseasesNiñoChild Preschool:Diseases::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders [Medical Subject Headings]Female:Named Groups::Persons::Age Groups::Infant [Medical Subject Headings]Risk assessmentAdulthierarchical spatial modelsAdolescentAncianoSistemas de Información Geográfica:Check Tags::Male [Medical Subject Headings]:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Cluster Analysis [Medical Subject Headings]:Named Groups::Persons::Age Groups::Infant::Infant Newborn [Medical Subject Headings]Risk AssessmentCalcioWater Supply:Chemicals and Drugs::Inorganic Chemicals::Metals::Metals Alkaline Earth::Calcium [Medical Subject Headings]Environmental health:Named Groups::Persons::Age Groups::Adult [Medical Subject Headings]:Chemicals and Drugs::Inorganic Chemicals::Metals::Metals Light::Magnesium [Medical Subject Headings]Humans:Chemicals and Drugs::Inorganic Chemicals::Hydroxides::Water [Medical Subject Headings]:Named Groups::Persons::Age Groups::Adult::Aged [Medical Subject Headings]:Diseases::Cardiovascular Diseases [Medical Subject Headings]Socioeconomic status:Named Groups::Persons::Age Groups::Child [Medical Subject Headings]Agedbusiness.industry:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Assessment [Medical Subject Headings]Public Health Environmental and Occupational HealthInfant NewbornInfantWaterLactanteEnvironmental ExposureValores de ReferenciaAnálisis por ConglomeradosEstudios Epidemiológicosenvironmental epidemiologyCerebrovascular DisordersEpidemiologic StudiesTrastornos Cerebrovasculares:Check Tags::Female [Medical Subject Headings]Relative riskspatial smoothingCalciumbusinessMedición de Riesgo:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies [Medical Subject Headings]Environmental epidemiology
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The 15-Country Collaborative Study of Cancer Risk Among Radiation Workers in the Nuclear Industry: design, epidemiological methods and descriptive re…

2007

International audience; Radiation protection standards are based mainly on risk estimates from studies of atomic bomb survivors in Japan. The validity of extrapolations from the relatively high-dose acute exposures in this population to the low-dose, protracted or fractionated environmental and occupational exposures of primary public health concern has long been the subject of controversy. A collaborative retrospective cohort study was conducted to provide direct estimates of cancer risk after low-dose protracted exposures. The study included nearly 600,000 workers employed in 154 facilities in 15 countries. This paper describes the design, methods and results of descriptive analyses of th…

GerontologyMaleNeoplasms Radiation-Induced[SDV]Life Sciences [q-bio]International Cooperationradiation exposurenuclear industrycancer riskWhole-Body Counting030218 nuclear medicine & medical imagingCohort Studies0302 clinical medicineNuclear ReactorsRisk FactorsNeoplasmscancer mortalityEpidemiology of cancerMedicineeducation.field_of_studyRadiationarticlemethodologycohort analysis3. Good healthOccupational DiseasesSurvival Ratepriority journalrisk factorstatisticsResearch Design030220 oncology & carcinogenesisepidemiologyFemalelightradiation doseRisk assessmentcancer epidemiologyradiation injuryCohort studyAdultEmploymentPopulationBiophysicsOccupational diseaseEpidemiological methodRadiation DosagesurvivalRisk Assessment03 medical and health sciencesEnvironmental healthOccupational Exposurefollow upHumansIndustryRadiology Nuclear Medicine and imaginghumaneducationindustrial workerbusiness.industryRetrospective cohort studymedicine.diseaseCollective dosemortalitySurvival Analysiswhole body countingRadiation-Inducedoccupational diseasenuclear reactorbusinessEpidemiologic MethodsRadiation research
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Smoking cessation opportunities in severe mental illness (tobacco intensive motivational and estimate risk — TIMER—): study protocol for a randomized…

2019

There is an increased risk of premature death in people with severe mental illness (SMI). Respiratory disorders and cardiovascular disease are leading causes of increased mortality rates in these patients, and tobacco consumption remains the most preventable risk factor involved. Developing new tools to motivate patients towards cessation of smoking is a high priority. Information on the motivational value of giving the lung age and prevention opportunities is unknown in this high-risk population. In the context of community care, screening and early detection of lung damage could potentially be used, together with mobile technology, in order to produce a prevention message, which may provi…

Health Knowledge Attitudes PracticeBipolar DisorderTime FactorsWireless technology:Phenomena and Processes::Physical Phenomena::Time::Time Factors [Medical Subject Headings]medicine.medical_treatmentHealth Behavior:Psychiatry and Psychology::Mental Disorders::Mood Disorders::Affective Disorders Psychotic::Bipolar Disorder [Medical Subject Headings]:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Tobacco Use::Smoking [Medical Subject Headings]Medicine (miscellaneous)EsquizofreniaSmoking PreventionSeverity of Illness Indexlaw.invention:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]Tecnología inalámbricaStudy ProtocolPulmonary Disease Chronic Obstructive0302 clinical medicineRandomized controlled triallawEnfermedad pulmonar obstructiva crónicaMulticenter Studies as TopicPharmacology (medical)Prospective Studies030212 general & internal medicineProspective cohort studyLungRandomized Controlled Trials as Topic:Psychiatry and Psychology::Behavioral Disciplines and Activities::Schizophrenic Psychology [Medical Subject Headings]lcsh:R5-920:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Evaluation Studies as Topic::Clinical Trials as Topic::Controlled Clinical Trials as Topic::Randomized Controlled Trials as Topic [Medical Subject Headings]COPDeducation.field_of_study:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Health Behavior [Medical Subject Headings]Chronic obstructive pulmonary diseaseSmokingTrastorno bipolar:Anthropology Education Sociology and Social Phenomena::Education::Education Nonprofessional::Health Education::Patient Education as Topic [Medical Subject Headings]Cese del uso del tabacoTobacco cessation:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Health Surveys::Health Status Indicators::Patient Acuity::Severity of Illness Index [Medical Subject Headings]Treatment OutcomeScreeningSchizophrenic Psychologylcsh:Medicine (General)medicine.medical_specialty:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective Studies [Medical Subject Headings]Bipolar disorderPopulationContext (language use)03 medical and health sciencesPatient Education as Topic:Information Science::Information Science::Communications Media::Telecommunications::Telephone::Cellular Phone::Text Messaging [Medical Subject Headings]Mobile technologySeverity of illness:Psychiatry and Psychology::Mental Disorders::Schizophrenia and Disorders with Psychotic Features::Schizophrenia [Medical Subject Headings]medicine:Diseases::Respiratory Tract Diseases::Lung Diseases::Lung Diseases Obstructive::Pulmonary Disease Chronic Obstructive [Medical Subject Headings]HumansRisk factoreducation:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Treatment Outcome [Medical Subject Headings]:Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings]MotivationText Messagingbusiness.industry:Anatomy::Respiratory System::Lung [Medical Subject Headings]:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Motivation [Medical Subject Headings]medicine.disease:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Evaluation Studies as Topic::Clinical Trials as Topic::Multicenter Studies as Topic [Medical Subject Headings]SpainEmergency medicineSchizophreniaSmoking cessation:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Tobacco Use::Tobacco Use Cessation::Smoking Cessation [Medical Subject Headings]Smoking Cessationbusiness030217 neurology & neurosurgeryTrials
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Morphological and Postural Changes in the Foot during Pregnancy and Puerperium: A Longitudinal Study

2021

The aim of this study is to observe the morphological and postural changes to the foot that take place during pregnancy and the puerperium. Method: In this descriptive, observational, longitudinal study, we analysed 23 pregnant women, with particular attention to morphological and postural aspects of the foot, at three time points during and after pregnancy: in weeks 9–13 of gestation, weeks 32–35 of gestation and weeks 4–6 after delivery. The parameters considered were changes in foot length, the Foot Posture Index (FPI) and the Hernández Corvo Index, which were analysed using a pedigraph and taking into account the Body Mass Index (BMI). The same procedure was conducted in each review. Re…

Longitudinal study:Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Postpartum Period [Medical Subject Headings]Health Toxicology and MutagenesisPregnancy puerperiumlcsh:MedicineFoot posture index:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]pedograph0302 clinical medicinePregnancyLongitudinal Studies:Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Pregnancy Trimesters::Pregnancy Trimester Third [Medical Subject Headings]reproductive and urinary physiology:Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Reproduction::Pregnancy [Medical Subject Headings]ObstetricsIncidence (epidemiology)Postpartum PeriodPostpartum periodfoot posture indexPeriodo pospartoGestationFemalepregnancy puerperiumFoot (unit)medicine.medical_specialty:Persons::Persons::Women::Pregnant Women [Medical Subject Headings]EmbarazoPregnancy Trimester ThirdPosture:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Body Constitution::Body Weights and Measures::Body Mass Index [Medical Subject Headings]Article03 medical and health sciences:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Incidence [Medical Subject Headings]medicine.artery:Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Posture [Medical Subject Headings]:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies [Medical Subject Headings]medicineHumansPronationPregnancyPedographbusiness.industryFootlcsh:RPublic Health Environmental and Occupational HealthPie030229 sport sciencesmedicine.diseasePronaciónPlantar arch:Check Tags::Female [Medical Subject Headings]:Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Musculoskeletal Physiological Processes::Movement::Motor Activity::Pronation [Medical Subject Headings]foot:Anatomy::Body Regions::Extremities::Lower Extremity::Foot [Medical Subject Headings]businessBody mass index030217 neurology & neurosurgeryPostpartum period
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Reproducibility and Validity of a Short Food Frequency Questionnaire for Dietary Assessment in Children Aged 7–9 Years in Spain

2019

The purpose of this study was to examine if the short semi-quantitative food frequency questionnaire (FFQ) is a reliable and valid tool to assess the diet of Spanish children aged 7&ndash

Male0301 basic medicinevalidityDietary assessmentfood frequency questionnairemedicine.medical_treatmentalpha-Tocopherollcsh:TX341-641030209 endocrinology & metabolismNutrient intakeArticleCohort StudiesFood group03 medical and health sciences0302 clinical medicineNutrient24-hour dietary recall Mediterranean country childhood diet food frequency questionnaire nutrient intake nutritional biomarker reproducibility validitySurveys and QuestionnairesEnvironmental healthHumansMedicineVitamin DChildreproducibilitychildhoodnutritional biomarker24-hour dietary recallReproducibility030109 nutrition & dieteticsNutrition and Dieteticsnutrient intakebusiness.industryVitamin Efood and beveragesReproducibility of ResultsFood frequency questionnaireCarotenoidsDietNutrition AssessmentBlood chemistrySpainMediterranean countryFemaledietEnergy IntakeEpidemiologic Methodsbusinesslcsh:Nutrition. Foods and food supplyFood ScienceNutrients
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Comparison of body mass index (BMI) with the CUN-BAE body adiposity estimator in the prediction of hypertension and type 2 diabetes

2016

BACKGROUND: Obesity is a world-wide epidemic whose prevalence is underestimated by BMI measurements, but CUN-BAE (Clínica Universidad de Navarra - Body Adiposity Estimator) estimates the percentage of body fat (BF) while incorporating information on sex and age, thus giving a better match. Our aim is to compare the BMI and CUN-BAE in determining the population attributable fraction (AFp) for obesity as a cause of chronic diseases. METHODS: We calculated the Pearson correlation coefficient between BMI and CUN-BAE, the Kappa index and the internal validity of the BMI. The risks of arterial hypertension (AHT) and diabetes mellitus (DM) and the AFp for obesity were assessed using both the BMI a…

Male:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Anthropometry [Medical Subject Headings]:Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cross-Sectional Studies [Medical Subject Headings]ObesidadType 2 diabetesÍndice de masa corporalCUN-BAEBody Mass Index:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]Diabetes mellitus0302 clinical medicineMedicine030212 general & internal medicineBody mass indexAdiposity:Persons::Persons::Age Groups::Adult::Aged [Medical Subject Headings]education.field_of_studyDiabetisAnthropometryDiabetes:Diseases::Pathological Conditions Signs and Symptoms::Signs and Symptoms::Body Weight::Overweight::Obesity [Medical Subject Headings]Middle Aged:Anatomy::Tissues::Connective Tissue::Adipose Tissue [Medical Subject Headings]CausalityAdipose TissueBody fatHypertensionObesitatFemaleHipertensióResearch ArticleAdultmedicine.medical_specialty:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Anthropometry::Body Weights and Measures::Body Mass Index [Medical Subject Headings]Population:Check Tags::Male [Medical Subject Headings]030209 endocrinology & metabolismBody adiposity index:Health Care::Environment and Public Health::Public Health::Epidemiologic Factors::Causality [Medical Subject Headings]03 medical and health sciences:Diseases::Cardiovascular Diseases::Vascular Diseases::Hypertension [Medical Subject Headings]Population attributable fractionClassification of obesityInternal medicineHipertensiónHumansObesityeducation:Persons::Persons::Age Groups::Adult [Medical Subject Headings]Aged:Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Composition::Body Fat Distribution::Adiposity [Medical Subject Headings]Body volume indexbusiness.industryPublic Health Environmental and Occupational Health:Diseases::Endocrine System Diseases::Diabetes Mellitus::Diabetes Mellitus Type 2 [Medical Subject Headings]:Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings]medicine.diseaseObesityCross-Sectional StudiesEndocrinologyDiabetes Mellitus Type 2:Check Tags::Female [Medical Subject Headings]Attributable riskbusinessBody mass indexDemographyAntropometria
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Antilymphocyte Globulin for Prevention of Chronic Graft-versus-Host Disease.

2016

Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; BACKGROUND Chronic graft-versus-host disease (GVHD) is the leading cause of later illness and death after allogeneic hematopoietic stem-cell transplantation. We hypothesized that the inclusion of antihuman T-lymphocyte immune globulin (ATG) in a myeloablative conditioning regimen for patients with acute leukemia would result in a significant reduction in chronic GVHD 2 years after allogeneic peripheral-blood stem-cell transplantation from an HLA-identical sibling. METHODS We conducted a prospective, multicenter, open-label, randomized phase 3 study of ATG as part of …

Male:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models Statistical::Proportional Hazards Models [Medical Subject Headings]T-LymphocytesPhases of clinical researchGraft vs Host Disease:Named Groups::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings]Linfocitos t:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]Immunosuppressive Agent0302 clinical medicineTrasplante homólogoEstudios prospectivosMedicineCumulative incidenceProspective StudiesProspective cohort studyChildTransplantation Homologou:Chemicals and Drugs::Amino Acids Peptides and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Immune Sera::Antilymphocyte Serum [Medical Subject Headings]Acute leukemia:Anatomy::Cells::Blood Cells::Leukocytes::Leukocytes Mononuclear::Lymphocytes::T-Lymphocytes [Medical Subject Headings]:Diseases::Pathological Conditions Signs and Symptoms::Pathologic Processes::Disease Attributes::Chronic Disease [Medical Subject Headings]:Named Groups::Persons::Age Groups::Child::Child Preschool [Medical Subject Headings]Medicine (all)IncidenceSuero antilinfocíticoGeneral MedicineMiddle AgedModelos de riesgos proporcionales3. Good healthHumanosSurvival Rate030220 oncology & carcinogenesis:Named Groups::Persons::Age Groups::Adolescent [Medical Subject Headings]Child PreschoolFemale:Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Immunologic Factors::Immunosuppressive Agents [Medical Subject Headings]Immunosuppressive AgentsHumanHomologousAdultmedicine.medical_specialty:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective Studies [Medical Subject Headings]:Named Groups::Persons::Age Groups::Adult::Young Adult [Medical Subject Headings]AdolescentEnfermedad injerto contra huéspedDisease-Free Survival03 medical and health sciencesYoung AdultInternal medicine:Named Groups::Persons::Age Groups::Adult [Medical Subject Headings]HumansTransplantation HomologousSupervivencia sin enfermedadPreschoolSurvival rate:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Disease-Free Survival [Medical Subject Headings]:Named Groups::Persons::Age Groups::Child [Medical Subject Headings]Antilymphocyte SerumProportional Hazards ModelsTransplantationbusiness.industryEnfermedad crónicamedicine.diseaseInmunosupresoresAnti-thymocyte globulinSurgeryTransplantation:Diseases::Immune System Diseases::Graft vs Host Disease [Medical Subject Headings]Prospective Studie:Analytical Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures Operative::Transplantation::Transplantation Homologous [Medical Subject Headings]Graft-versus-host diseaseT-Lymphocyte:Check Tags::Female [Medical Subject Headings]Chronic DiseaseProportional Hazards ModelAdolescent; Adult; Antilymphocyte Serum; Child; Child Preschool; Chronic Disease; Disease-Free Survival; Female; Graft vs Host Disease; Humans; Immunosuppressive Agents; Incidence; Male; Middle Aged; Proportional Hazards Models; Prospective Studies; Survival Rate; T-Lymphocytes; Transplantation Homologous; Young Adult; Medicine (all)business030215 immunology
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Gut microbiota steroid sexual dimorphism and its impact on gonadal steroids: influences of obesity and menopausal status

2020

[Background]: Gonadal steroid hormones have been suggested as the underlying mechanism responsible for the sexual dimorphism observed in metabolic diseases. Animal studies have also evidenced a causal role of the gut microbiome and metabolic health. However, the role of sexual dimorphism in the gut microbiota and the potential role of the microbiome in influencing sex steroid hormones and shaping sexually dimorphic susceptibility to disease have been largely overlooked. Although there is some evidence of sex-specific differences in the gut microbiota diversity, composition, and functionality, the results are inconsistent. Importantly, most of these studies have not taken into account the go…

Male:Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cross-Sectional Studies [Medical Subject Headings]PhysiologyGut flora:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings]Mice:Chemicals and Drugs::Hormones Hormone Substitutes and Hormone Antagonists::Hormones::Gonadal Hormones [Medical Subject Headings]0302 clinical medicineOverweight persons:Organisms::Eukaryota::Animals [Medical Subject Headings]TestosteroneProgesteronaGonadal Steroid HormonesTestosteronaTestosteroneProgesterone:Persons::Persons::Age Groups::Adult::Aged [Medical Subject Headings]Sex Characteristics0303 health sciencesMicrobiotaIntestins -- MalaltiesMiddle AgedSex ; Gender ; Gonadal steroids ; Testosterone ; Progesterone ; Microbiome ; Sexual dimorphism.Persones obeses3. Good healthMenopause:Phenomena and Processes::Microbiological Phenomena::Microbiota [Medical Subject Headings]Intestins -- MicrobiologiaCaracteres sexualeslcsh:QR100-130Female:Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Climacteric::Menopause [Medical Subject Headings]SexAnimal studiesIntestines -- DiseasesMenopauseMenopausaAdultMicrobiology (medical):Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Sex Characteristics [Medical Subject Headings]:Check Tags::Male [Medical Subject Headings]SexoSteroid biosynthesisBiologyIntestines -- Microbiologydigestive systemMicrobiologylcsh:Microbial ecology:Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies [Medical Subject Headings]03 medical and health sciencesSexual dimorphismmedicineAnimalsHumansObesityMicrobiome:Persons::Persons::Age Groups::Adult [Medical Subject Headings]Aged030304 developmental biology:Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice [Medical Subject Headings]ResearchGender:Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings]medicine.diseasebiology.organism_classificationObesityGastrointestinal Microbiome:Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity [Medical Subject Headings]Gonadal steroidsSexual dimorphismCross-Sectional Studies:Check Tags::Female [Medical Subject Headings]Case-Control StudiesIdentidad de géneroMicrobiome030217 neurology & neurosurgeryMicrobiome
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A variant of the LRP4 gene affects the risk of chronic lymphocytic leukaemia transformation to Richter syndrome

2010

Richter syndrome (RS) represents the transformation of chronic lymphocytic leukaemia (CLL) to aggressive lymphoma. Risk factors of CLL transformation to RS are only partly known. We explored the role of the host genetic background as a risk factor for RS occurrence. Forty-five single nucleotide polimorphisms (SNPs) known to be relevant for CLL prognosis were genotyped in a consecutive cohort of 331 CLL, of which 21 had transformed to RS. After correcting for multiple testing and adjusting for previously reported RS risk factors, the LRP4 rs2306029 TT variant genotype was the sole SNP independently associated with a higher risk of RS transformation (Hazard Ratio: 4·17; P = 0·001; q = 0·047).…

MaleAged; Amino Acid Sequence; Animals; Disease Progression; Epidemiologic Methods; Female; Genetic Predisposition to Disease; Genotype; Humans; LDL-Receptor Related Proteins; Leukemia Lymphocytic Chronic B-Cell; Lymphoma; Male; Middle Aged; Molecular Sequence Data; Neoplasm Proteins; Polymorphism Single Nucleotide; Prognosis; Sequence Alignment; SyndromeGenotypeLymphomaMolecular Sequence DataLRP4genetics/metabolismRichter syndrome; chronic lymphocytic leukemia; LRP4 genePolymorphism Single NucleotideAnimalsHumansGenetic Predisposition to DiseaseAmino Acid SequenceChronicPolymorphismLDL-Receptor Related ProteinsAgedLeukemiaLRP4 geneB-CellSingle NucleotideSyndromeMiddle AgedPrognosisRichter syndrome.Leukemia Lymphocytic Chronic B-Cellsingle nucleotide polimorphismLymphocyticdiffuse large B cell lymphomaNeoplasm ProteinsAged Amino Acid Sequence Animals Disease Progression Epidemiologic Methods Female Genetic Predisposition to Disease Genotype Humans LDL-Receptor Related Proteins; genetics/metabolism Leukemia; Lymphocytic; Chronic; B-Cell; genetics/metabolism Lymphoma; genetics/metabolism Male Middle Aged Molecular Sequence Data Neoplasm Proteins; genetics/metabolism Polymorphism; Single Nucleotide Prognosis Sequence Alignment SyndromeSettore MED/15 - MALATTIE DEL SANGUERichter syndrome; chronic lymphocytic leukaemia; diffuse large B cell lymphoma; single nucleotide polimorphism; LRP4Disease Progressionchronic lymphocytic leukemiaFemaleRichter syndromeEpidemiologic MethodsSequence Alignmentchronic lymphocytic leukaemia
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A screening instrument for a Sicilian neuroepidemiological survey in the elderly.

2003

Abstract We evaluated the sensitivity and specificity of a screening instrument developed for use in a two-phase neuroepidemiological survey in Sicily. The Sicilian Epidemiological Dementia Study (SEDES) project will evaluate the prevalence and incidence of dementia, parkinsonisms and essential tremor in four Sicilian municipalities. It is a two-phase door-to-door survey. To identify subjects with possible neurological disorders, in this study, we developed a screening instrument including a symptoms questionnaire and simple physical tasks for parkinsonisms and essential tremor. The Mini-Mental State Examination (MMSE) was chosen for screening dementia. The symptoms questionnaire and simple…

MaleAgingmedicine.medical_specialtyHealth (social science)NeurologyParkinsonismSensitivity and SpecificityElderlySurveys and QuestionnairesValidationEpidemiologyTremormedicinePrevalenceDementiaHumansScreening instrumentGeriatric AssessmentSicilyAgedAged 80 and overEssential tremorbusiness.industryParkinsonismIncidence (epidemiology)IncidenceHealthy subjectsParkinson Diseasemedicine.diseasenervous system diseasesScreening instrumentPhysical therapyEssential tremorDementiaFemaleGeriatrics and GerontologybusinessEpidemiologic MethodsGerontologyArchives of gerontology and geriatrics
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