Search results for "equivalence"
showing 10 items of 301 documents
Defining level A IVIVC dissolution specifications based on individual in vitro dissolution profiles of a controlled release formulation.
2018
Regulatory guidelines recommend that, when a level A IVIVC is established, dissolution specification should be established using averaged data and the maximum difference between AUC and Cmax between the reference and test formulations cannot be greater than 20%. However, averaging data assumes a loss of information and may reflect a bias in the results. The objective of the current work is to present a new approach to establish dissolution specifications using a new methodology (individual approach) instead of average data (classical approach). Different scenarios were established based on the relationship between in vitro-in vivo dissolution rate coefficient using a level A IVIVC of a cont…
Integrating theoretical and experimental permeability estimations for provisional biopharmaceutical classification: Application to the WHO essential …
2018
The accuracy of the provisional estimation of the Biopharmaceutics Classification System (BCS) is heavily influenced by the permeability measurement. In this study, several theoretical and experimental models currently employed for BCS permeability classification have been analysed. The experimental models included the in situ rat intestinal perfusion, the ex vivo rat intestinal tissue in an Ussing chamber, the MDCK and Caco-2 cell monolayers, and the parallel artificial membrane (PAMPA). The theoretical models included the octanol-water partition coefficient and the QSPeR (Quantitative Structure-Permeability Relationship) model recently developed. For model validation, a dataset of 43 comp…
Chairs' welcome message
2004
In this paper we present techniques for comparison between behavioral level and register transfer level (RTL) design descriptions by mapping the designs into virtual controllers and virtual datapaths. We also discuss about how the equivalence between behavioral level and RTL designs can be defined precisely using the proposed "attribute statements" in an interactive fashion. Implementation issues as well as considerations on real life industrial design examples are presented as well.
Improvement of Inventory Control under Parametric Uncertainty and Constraints
2011
The aim of the present paper is to show how the statistical inference equivalence principle (SIEP), the idea of which belongs to the authors, may be employed in the particular case of finding the effective statistical decisions for the multi-product inventory problems with constraints. To our knowledge, no analytical or efficient numerical method for finding the optimal policies under parametric uncertainty for the multi-product inventory problems with constraints has been reported in the literature. Using the (equivalent) predictive distributions, this paper represents an extension of analytical results obtained for unconstrained optimization under parametric uncertainty to the case of con…
Preclinical Effect of Absorption Modifying Excipients on Rat Intestinal Transport of Model Compounds and the Mucosal Barrier Marker 51Cr-EDTA
2017
There is a renewed interest from the pharmaceutical field to develop oral formulations of compounds, such as peptides, oligonucleotides, and polar drugs. However, these often suffer from insufficient absorption across the intestinal mucosal barrier. One approach to circumvent this problem is the use of absorption modifying excipient(s) (AME). This study determined the absorption enhancing effect of four AMEs (sodium dodecyl sulfate, caprate, chitosan, N-acetylcysteine) on five model compounds in a rat jejunal perfusion model. The aim was to correlate the model compound absorption to the blood-to-lumen clearance of the mucosal marker for barrier integrity, 51Cr-EDTA. Sodium dodecyl sulfate a…
A new proof for the equivalence of weak and viscosity solutions for the p-Laplace equation
2011
In this paper, we give a new proof for the fact that the distributional weak solutions and the viscosity solutions of the $p$-Laplace equation $-\diver(\abs{Du}^{p-2}Du)=0$ coincide. Our proof is more direct and transparent than the original one by Juutinen, Lindqvist and Manfredi \cite{jlm}, which relied on the full uniqueness machinery of the theory of viscosity solutions. We establish a similar result also for the solutions of the non-homogeneous version of the $p$-Laplace equation.
Mapping wordnets from the perspective of inter-lingual equivalence
2017
Mapping wordnets from the perspective of inter-lingual equivalence This paper explores inter-lingual equivalence from the perspective of linking two large lexico-semantic databases, namely the Princeton WordNet of English and the plWordnet ( pl. Slowosiec ) of Polish. Wordnets are built as networks of lexico-semantic relations between words and their meanings, and constitute a type of monolingual dictionary cum thesaurus. The development of wordnets for different languages has given rise to many wordnet linking projects (e.g. EuroWordNet, Vossen, 2002). Regardless of a linking method used, these projects require defining rules for establishing equivalence links between wordnet building bloc…
DISCOURSE INTERFERENCE IN TRANSLATION
2001
This article focuses on three major factors that may enhance the degree of hybridity of target texts: first, the ideological background, i.e., the prestige accorded to the source culture in relation to the target culture; second, translator's competence, i.e., the translator's ability to rationalise translation process and choose an adequate translation strategy; third, the skopos of translation, i.e., hybrid features may be deliberately imposed upon the translation to enable the text to serve a given function. Each of these factors is analysed within a framework of a concrete text. The conclusion of this analysis is that due to the functionalist approach, the concept of translation has bec…
Contrasting the form and use of reformulation markers
2007
This article deals with the form and use of reformulation markers in research papers written in English, Spanish and Catalan. Considering the form and frequency of the markers, English papers tend to prefer simple fixed markers and include fewer reformulators than Spanish and Catalan. On the contrary, formal Catalan and Spanish papers include more markers, some of which are complex and allow for some structural variability. As for use, reformulation markers establish dynamic relationships between portions of discourse which can be identified in our corpus with expansion, reduction and permutation. The analysis of the corpus shows that English authors usually reformulate to add more informa…
Meaning Construction for Biodynamic Osteopathy Terms in Translation Practice
2021
This article belongs to the interface of terminology and translation studies and aims to describe the principles of meaning construction in the translation of field-specific terms in biodynamic osteopathy. The central problem of the study presented in this paper deals with identification and analysis of measurable components of meaning of terminological units. The data for the study comprises a corpus of 210 English terms in the field of biodynamic osteopathy translated into French, Italian, Russian and Latvian. Following the analysis of the meanings of the terms through their contextual uses, it is possible to assess other factors that contribute to the content of these units.Methodologica…