Search results for "esca"
showing 10 items of 966 documents
The neuropeptide Pth2 modulates social behavior and anxiety in zebrafish
2021
SummaryAnimal behavior is strongly context-dependent and behavioral performance is often modulated by internal state. In particular, different social contexts can alter anxiety levels and modulate social behavior. The vertebrate-specific neuropeptide parathyroid hormone 2 (pth2) is directly regulated by the presence or absence of conspecifics in zebrafish. As its cognate receptor, the parathyroid hormone 2 receptor (pth2r), is widely expressed across the brain, we tested fish lacking the functional Pth2 peptide in several anxiety-related and social paradigms. Rodents lacking PTH2 display increased anxiety-related behavior. Here we show that the propensity to react to sudden stimuli with an …
Women's satisfaction with the experience of childbirth: validation of the Mackey Childbirth Satisfaction Rating Scale
2012
Objetivos: Determinar la fiabilidad y validez de contenido y concepto de la Mackey Childbirth Satisfaction Rating Scale, escala para medir la satisfacción de las mujeres con el parto y el nacimiento. Métodos: Se utilizó el método de traducción-retrotraducción para obtener una versión adaptada de la escala. Para la validación se seleccionó una muestra de 325 mujeres que habían tenido un hijo sano mediante parto vaginal. La recogida de datos se realizó con un cuestionario autocumplimentado que incluía la escala adaptada, expectativas ante el parto y variables obstétricas y sociodemográficas. Se valoró la fiabilidad en una submuestra de 45 mujeres que cumplimentaron de nuevo la escala a los 15…
Satisfacción de las mujeres con la experiencia del parto: validación de la Mackey Satisfaction Childbirth Rating Scale Women's satisfaction with the …
2012
Objetivos: Determinar la fiabilidad y validez de contenido y concepto de la Mackey Childbirth Satisfaction Rating Scale, escala para medir la satisfacción de las mujeres con el parto y el nacimiento. Métodos: Se utilizó el método de traducción-retrotraducción para obtener una versión adaptada de la escala. Para la validación se seleccionó una muestra de 325 mujeres que habían tenido un hijo sano mediante parto vaginal. La recogida de datos se realizó con un cuestionario autocumplimentado que incluía la escala adaptada, expectativas ante el parto y variables obstétricas y sociodemográficas. Se valoró la fiabilidad en una submuestra de 45 mujeres que cumplimentaron de nuevo la escala a los 15…
L'ordine dell'amore in Blaise Pascal
2021
The author focuses on the question of love in Pascal which finds its most exhaustive treatment in the fragment on the three orders. Furthermore, it focuses on the epistemological and ethical implications of Pascal's thesis.
Pascal and the question of technique
2017
The purpose of the essay is to discuss some implications of Pascal's philosophical discourse on the problem of technique and his rejections of Cartesian metaphysics. Author shows a singular perspective about technic in Blaise Pascal's philosophy. This perspective marks the difference with Descartes, linking technic to hearth and memory.
Uloga glazbe u dubrovackom pastoralnom teatru u 16. stoljecu. (The Role of the Music in the Pastoral Theatre in Dubrovnik during the Sixteenth Centur…
2004
The 16th-century pastoral plays in Dubrovnik (Ragusa), like the Italian ones which inspired them, are marked by the strong presence of sounds, songs and choruses to increase the fantastical and sentimental emphasis of the performances. Their evolution, from Dzore Drzic eclogues to the pastorals of Antun Sasin, and through Mauro Vetranovic's "Orfeo", is characterized by the acquisition of a Petrarchian language in the Croatian pieces of Nikola Naljeskovic. In the Dubrovnik pastoral plays, unlike the Italian ones, the presence of shepherds, nymphs, and rustic men (the "vlasi", Engl. Walachians or Morlacks) as well as the fantastic and comic elements, is constant. Music supports a narrative fu…
Radiolabeled DNase, a potential indicator for noninvasive detection of tissue damage
1983
Pancreatic DNase I was labeled with 131I or fluorescamine and injected IV into NMRI mice bearing a sarcoma 180. Of the injected tracer, 1.5%-2% was found to accumulate per g tumor. In sections of tumor tissue DNase was localized in damaged cells in solid and necrotic tumor regions. This binding is most probably due to specific interaction of DNase with actin, an ubiquitous cytoskeletal protein. Two-component blood clearance with a rapid first component (two-thirds of applied radioactivity) was observed. The labeled tumor could easily be visualized by gamma camera imaging. The findings suggest DNase to be a potent radiopharmaceutical for imaging damaged tissue, occurring in malignant tumors …
Acquired IFNγ resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions
2016
Melanoma treatment has been revolutionized by antibody-based immunotherapies. IFNγ secretion by CD8+ T cells is critical for therapy efficacy having anti-proliferative and pro-apoptotic effects on tumour cells. Our study demonstrates a genetic evolution of IFNγ resistance in different melanoma patient models. Chromosomal alterations and subsequent inactivating mutations in genes of the IFNγ signalling cascade, most often JAK1 or JAK2, protect melanoma cells from anti-tumour IFNγ activity. JAK1/2 mutants further evolve into T-cell-resistant HLA class I-negative lesions with genes involved in antigen presentation silenced and no longer inducible by IFNγ. Allelic JAK1/2 losses predisposing to …
Hemeroskopeion=Thynnoskopeion. El final d'un problema històric mal enfocat.
2005
Fernandez Nieto, Fco Javier - E-mail @uv.es: privado (a solicitud del interesado) El nom d'hemeroskopeion no designa cap colònia o emporion, sinó que va correspondre a una talaia situada sobre el castell de Dénia i utilitzada pels grecs de l'àmbit de Massàlia per a practicar la pesca de la tonyina per mitjà de sentinella (thynnoskopeion) i almadraves. S'estudien també els aspectes tècnics d'aquesta manera de pesca, els econòmics (factoria de saladura a Dénia, sal) i religiosos (consagració de la talaia a Artemis com a divinitat que propicia la pesca).